Cancer Cell Signaling
Cancer Cell Signaling
批准号:
8231120
负责人:
MICHAEL J. WEBER
金额:
$2.87万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2012
资助国家:
美国
项目状态:
已结题
起止时间:
2012-02-01 至 2017-01-31
关键词:
Cancer CenterCancer Center Support GrantCancer ModelCell Culture TechniquesCellsCollaborationsCommunicationComplexDevelopmentDiagnosisDoctor of PhilosophyEnvironmentExtramural ActivitiesFosteringFundingFutureGenetically Engineered MouseGoalsGraduate EducationGrantIn VitroIndividualInstitutesInstructionJournalsKnowledgeLeadershipMalignant NeoplasmsOncologistPaperPathway interactionsPharmaceutical PreparationsPreclinical TestingPreventionPropertyPublishingResearchResource SharingScienceShapesSignal PathwaySignal TransductionSurgeonSystemTechnologyTherapeutic InterventionTranslationsXenograft Modelcancer cellcancer therapyclinical applicationexperienceimprovedin vivoin vivo Modelinnovationmembermouse modelneoplastic cellpostgraduate educationpre-clinicalprogramsresponsetumor
中文摘要
癌症细胞信号程序(SIG)是由研究人员致力于提供基本的
英文摘要
The Cancer Cell Signaling Program (SIG) is comprised of invesfigators dedicated to providing fundamental
knowledge of the intra- and inter-cellular signaling pathways that control tumor cell proliferafion, migrafion,
and survival and to understanding how this informafion can be used to improve the diagnosis, prevention,
and treatment of cancer. Program members utilize this fundamental knowledge to study tumor cell
responses to the microenvironment and to drug treatments, using in vitro cell culture models and in vivo
genetically engineered mouse models and xenograft models of individual cancers. Studying cell signaling in
the context of pre-clinical cancer models provides relevant translation of cell signaling to the practical context
of therapeutic intervention.
SIG is led by David Brautigan, PhD and J. Thomas Parsons, PhD both of whom have extensive experience
in cell signaling research and programmatic and administrative leadership. The Program leaders catalyze
advances in signaling research by organizing retreats to foster new and innovative approaches, dispense
"mini" pilot grants to stimulate the development of new ideas and technologies with an emphasis on using
Cancer Center Shared Resources, and contribute to the overall intellectual environment of the Cancer
Center by participating in seminars, journal clubs, research in progress and graduate and postgraduate
education.
The research of the 22 members of SIG is organized around three themes: (1) understanding fundamental
properties of cancer cell signaling networks; (2) identifying pathways that govern cell responses to the
microenvironment; and (3) defining in vivo systems to study signaling networks and test preclinical
therapeufic strategies for cancer treatment. Total extramural funding for the Program exceeds $18 million,
including $2.5 million from the Nafional Cancer Institute (NCI). Over the past five years, SIG Members have
published 504 Program-relevant papers of which 33% were inter-Programmatic and 13% were intra
Programmatic. The future goals of SIG are to foster discovery science focused on the complex integrafion of
signaling networks, on how tumors respond to the microenvironment, and how tumors evolve to survive anti
cancer therapies. SIG will confinue to utilize the outstanding Shared Resources and promote collaboration
and innovation. Finally, SIG will engage oncologists and surgeons within the program and Cancer Center to
seize opportunities for translation of information on signaling networks to clinical applications.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Adaptive signaling exposes a therapeutic vulnerability in NRAS melanomas
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批准号:8621637
-
项目类别:
-
资助金额:$20.62万
-
财政年份:2014
-
负责人:MICHAEL J. WEBER
-
依托单位:
Senior Leadership
-
批准号:8724657
-
项目类别:
-
资助金额:$2.08万
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财政年份:2013
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负责人:MICHAEL J. WEBER
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依托单位:
Senior Leadership
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批准号:8719585
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项目类别:
-
资助金额:$2.5万
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财政年份:2013
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负责人:MICHAEL J. WEBER
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依托单位:
Senior Leadership
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批准号:8231151
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项目类别:
-
资助金额:$38.41万
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财政年份:2012
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负责人:MICHAEL J. WEBER
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依托单位:
Molecular Genetics and Epigenetics
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批准号:8231124
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项目类别:
-
资助金额:$2.87万
-
财政年份:2012
-
负责人:MICHAEL J. WEBER
-
依托单位:
Protocol Review and Monitoring System
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批准号:8231149
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项目类别:
-
资助金额:$6.59万
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财政年份:2012
-
负责人:MICHAEL J. WEBER
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依托单位:
Gene Targeting and Transgenic Facility
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批准号:8231142
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项目类别:
-
资助金额:$3.76万
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财政年份:2012
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负责人:MICHAEL J. WEBER
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依托单位:
Immunology/Immunotherapy
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批准号:8231128
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项目类别:
-
资助金额:$2.87万
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财政年份:2012
-
负责人:MICHAEL J. WEBER
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依托单位:
Biomolecular Analysis
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批准号:8231134
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项目类别:
-
资助金额:$15.63万
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财政年份:2012
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负责人:MICHAEL J. WEBER
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依托单位:
Developmental Funds
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批准号:8231154
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项目类别:
-
资助金额:$56.43万
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财政年份:2012
-
负责人:MICHAEL J. WEBER
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依托单位:
Administration
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批准号:8231155
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项目类别:
-
资助金额:$27.47万
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财政年份:2012
-
负责人:MICHAEL J. WEBER
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依托单位:
Women's Oncology
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批准号:8231125
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项目类别:
-
资助金额:$2.87万
-
财政年份:2012
-
负责人:MICHAEL J. WEBER
-
依托单位:
Biorepository & Tissue Research Facility
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批准号:8231138
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项目类别:
-
资助金额:$9.39万
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财政年份:2012
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负责人:MICHAEL J. WEBER
-
依托单位:
Office for Clinical Research
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批准号:8231148
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项目类别:
-
资助金额:$25.89万
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财政年份:2012
-
负责人:MICHAEL J. WEBER
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依托单位:
Chemical and Structural Biology
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批准号:8231121
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项目类别:
-
资助金额:$2.53万
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财政年份:2012
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负责人:MICHAEL J. WEBER
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依托单位:
Biostatistics
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批准号:8231144
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项目类别:
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资助金额:$20.05万
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财政年份:2012
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负责人:MICHAEL J. WEBER
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依托单位:
Preclinical Imaging and Tumor Analysis
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批准号:8231143
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项目类别:
-
资助金额:$8.33万
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财政年份:2012
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负责人:MICHAEL J. WEBER
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依托单位:
Flow Cytometry
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批准号:8231139
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项目类别:
-
资助金额:$6.03万
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财政年份:2012
-
负责人:MICHAEL J. WEBER
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依托单位:
Integration of Androgen and Growth Factor Signaling in Prostate Cancer
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批准号:7728881
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项目类别:
-
资助金额:$22.08万
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财政年份:2008
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负责人:MICHAEL J. WEBER
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依托单位:
Program Planning & Evaluation
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批准号:7304682
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项目类别:
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资助金额:$1.15万
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财政年份:2006
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负责人:MICHAEL J. WEBER
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依托单位:
海外基金