Cancer Cell Signaling

癌细胞信号转导

• 批准号: 8231120
• 负责人: MICHAEL J. WEBER
• 金额: $ 2.87万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8231120
• 关键词: Cancer Center; Cancer Center Support Grant; Cancer Model; Cell Culture Techniques; Cells; Collaborations; Communication; Complex; Development; Diagnosis; Doctor of Philosophy; Environment; Extramural Activities; Fostering; Funding; Future; Genetically Engineered Mouse; Goals; Graduate Education; Grant; In Vitro; Individual; Institutes; Instruction; Journals; Knowledge; Leadership; Malignant Neoplasms; Oncologist; Paper; Pathway interactions; Pharmaceutical Preparations; Preclinical Testing; Prevention; Property; Publishing; Research; Resource Sharing; Science; Shapes; Signal Pathway; Signal Transduction; Surgeon; System; Technology; Therapeutic Intervention; Translations; Xenograft Model; cancer cell; cancer therapy; clinical application; experience; improved; in vivo; in vivo Model; innovation; member; mouse model; neoplastic cell; postgraduate education; pre-clinical; programs; response; tumor

The Cancer Cell Signaling Program (SIG) is comprised of invesfigators dedicated to providing fundamental knowledge of the intra- and inter-cellular signaling pathways that control tumor cell proliferafion, migrafion, and survival and to understanding how this informafion can be used to improve the diagnosis, prevention, and treatment of cancer. Program members utilize this fundamental knowledge to study tumor cell responses to the microenvironment and to drug treatments, using in vitro cell culture models and in vivo genetically engineered mouse models and xenograft models of individual cancers. Studying cell signaling in the context of pre-clinical cancer models provides relevant translation of cell signaling to the practical context of therapeutic intervention. SIG is led by David Brautigan, PhD and J. Thomas Parsons, PhD both of whom have extensive experience in cell signaling research and programmatic and administrative leadership. The Program leaders catalyze advances in signaling research by organizing retreats to foster new and innovative approaches, dispense "mini" pilot grants to stimulate the development of new ideas and technologies with an emphasis on using Cancer Center Shared Resources, and contribute to the overall intellectual environment of the Cancer Center by participating in seminars, journal clubs, research in progress and graduate and postgraduate education. The research of the 22 members of SIG is organized around three themes: (1) understanding fundamental properties of cancer cell signaling networks; (2) identifying pathways that govern cell responses to the microenvironment; and (3) defining in vivo systems to study signaling networks and test preclinical therapeufic strategies for cancer treatment. Total extramural funding for the Program exceeds $18 million, including $2.5 million from the Nafional Cancer Institute (NCI). Over the past five years, SIG Members have published 504 Program-relevant papers of which 33% were inter-Programmatic and 13% were intra Programmatic. The future goals of SIG are to foster discovery science focused on the complex integrafion of signaling networks, on how tumors respond to the microenvironment, and how tumors evolve to survive anti cancer therapies. SIG will confinue to utilize the outstanding Shared Resources and promote collaboration and innovation. Finally, SIG will engage oncologists and surgeons within the program and Cancer Center to seize opportunities for translation of information on signaling networks to clinical applications.

癌症细胞信号传导计划（SIG）由致力于提供基础研究的研究人员组成。 控制肿瘤细胞增殖，迁移， 和生存率，并了解如何利用这些信息来改善诊断，预防， 和治疗癌症。项目成员利用这些基础知识研究肿瘤细胞 使用体外细胞培养模型和体内细胞培养模型， 基因工程小鼠模型和个体癌症的异种移植模型。研究细胞信号 临床前癌症模型的背景提供了细胞信号传导到实际背景的相关翻译 治疗干预。 SIG由大卫Brautigan博士和J.托马斯帕森斯博士领导，他们都有丰富的经验 在细胞信号研究和规划和行政领导。项目领导者催化 通过组织务虚会促进新的和创新的方法， “小型”试验赠款，以鼓励发展新意念和新技术， 癌症中心共享资源，为癌症中心的整体智力环境做出贡献 中心通过参加研讨会，期刊俱乐部，研究进展和研究生和研究生 教育 SIG的22名成员的研究围绕三个主题进行组织：（1）了解基本的 癌细胞信号传导网络的性质;（2）识别控制细胞对肿瘤细胞信号传导网络的反应的途径。 微环境;和（3）定义体内系统，以研究信号网络和测试临床前 癌症治疗的治疗策略。该计划的校外资金总额超过1800万美元， 其中250万美元来自美国国家癌症研究所（NCI）。在过去的五年里，SIG成员 发表了504篇与方案有关的论文，其中33%是方案间的，13%是方案内的 程序化。SIG的未来目标是促进发现科学，重点是复杂的整合， 信号网络，肿瘤如何对微环境作出反应，以及肿瘤如何进化以在抗 癌症治疗SIG将致力于利用优秀的共享资源，促进合作 创新添最后，SIG将在项目和癌症中心内聘请肿瘤学家和外科医生， 抓住机会，将信号网络上的信息转化为临床应用。