Molecular Targets COBRE

路易斯维尔大学生物医学研究卓越分子靶点中心（MT-COBRE）专注于癌症治疗新分子靶点的鉴定，强调结构生物学方法用于新疗法的开发。MT-COBRE的总体目标是招募并确保UofL布朗癌症中心分子靶标项目成员的初级研究人员取得成功。在第一个五年资助期内，我们在实现最初申请的目标方面取得了相当大的进展。COBRE最初的五名科学家中有四名获得了NIH R01资助，第五名被鼓励追求其他方向。五位杰出的新科学家取代了他们的位置，其中三位正在审查NIH R01申请或正在修改以重新提交。我们非常幸运，在最初的资助阶段，我们保留了所有的麻省理工学院的教员。我们利用MT-COBRE的支持创建了一套有效的核心设施，这大大提高了MT-COBRE研究人员和其他布朗癌症中心科学家的生产力。更新申请增加了一个新的核心，即生物物理学核心设施，并删除了一个未充分利用的核心，即蛋白质组学核心设施。该建议的具体目的是：

The University of Louisville Molecular Targets Center of Biomedical Research Excellence (MT-COBRE) is focused on identification of novel molecular targets for cancer therapy, emphasizing structural biologic approaches for development of novel therapeutics. The overall objective of the MT-COBRE is to recruit and ensure the success of junior investigators who are members of the Molecular Targets Program at the UofL's Brown Cancer Center. We have made considerable progress towards accomplishment of the goals of the original application during the first five year funding period. Four of the original five COBRE scientists have received NIH R01 funding, the fifth was encouraged to pursue other directions. Five outstanding new scientists have taken their places, three of whom have NIH R01 applications under review or being revised for resubmission. We have been quite fortunate, during the initial funding period, to have retained all of the MT-COBRE faculty. We have leveraged the MT-COBRE support to create a set of effective Core Facilities which have significantly enhanced the productivity of the MT-COBRE investigators and other Brown Cancer Center scientists. The renewal application has added a new Core, the Biophysics Core Facility, and deleted a Core which was underutilized, the Proteomics Core Facility. The specific aims of the proposal are to: 1. develop successful independent research careers for each of the principal investigators that will lead to independent R01 grants. 2. develop core facilities that will enhance the research capability of the principal investigators and the other members of the MT program. 3. continue to develop the Molecular Targets Program as a cohesive research program which will enhance collaborative research projects and funding opportunities. 4. develop a nationally and internationally recognized program which will attract the very best graduate students, postdoctoral fellows and additional faculty. 5. make discoveries leading to new and more effective treatments for patients with cancer. During the next funding period, the MT-COBRE will utilize focused recruitment to enhance the scope of the program. Funding of this renewal application is critically important to allow the program to achieve its potential. Based on its current faculty and projected growth during the next funding period, this program is poised to become one of the nation's premiere cancer drug development programs.