Collaborations to Advance Research and Ethics (CURE)

描述（由申请人提供）：西北生物医学研究协会（NWABR）是一个促进对生物医学研究的理解和支持的非营利组织，将利用其在生物伦理学教师培训和课程开发方面的丰富经验，以及其成员研究组织的伙伴关系，开发一个高度协作和多方面的推广计划，“合作理解科学和伦理（CURE）”。我们的长期目标包括提高公众对生物医学研究本质和科学与伦理关系的理解，特别强调转化研究——将基础研究应用于临床疗法开发的过程。该项目的具体目标是：1)为以转化研究的科学和伦理为目标的初高中生命科学教育者提供教师专业发展和课程资源；2)为学生提供学习经验，以增加他们对转化研究和伦理的理解；3)传播通过CURE计划开发的资源和材料。包括以下活动：1)“生物医学研究-科学与伦理”教师专业发展研讨会，包括与研究设施中的科学家和审查研究方案的个人进行讨论；2)为中学开发“研究诚信”课程，重点关注研究过程和适用于科学行为的道德标准，在研究中使用动物，以及人体临床试验；3)为来自少数族裔背景的高中三年级学生提供“生物医学研究研究员”计划，提供实验室参观，与科学家互动，以及对研究过程的广泛概述；4)“青年伦理峰会”，将参与我们专业发展的学生和教师聚集在一起，与伦理学家和其他学生进行互动讨论，并展示与生物伦理学相关的项目。第二阶段的传播将通过与华盛顿大学合作开发在线教师课程、研讨会以及通过美国生物科学研究所的行动生物科学网站等合作伙伴的网络来完成。项目评估将利用定性和定量研究措施，包括实验组和对照组来检查教师专业发展项目对学生学习的影响。

DESCRIPTION (provided by applicant): The Northwest Association for Biomedical Research (NWABR), a non-profit organization that advances the understanding and support of biomedical research, will utilize its extensive experience in bioethics teacher training and curriculum development as well as the partnership of its member research organizations to develop a highly collaborative and multi-faceted outreach program, "Collaborations to Understand Science and Ethics (CURE)". Our long-term goals include increasing public understanding of both the nature of biomedical research and the relationship of science and ethics, with a special emphasis on translational research - the process of applying basic research to the development of clinical therapies. The specific aims of this project are to: 1) Provide teacher professional development and curricular resources for middle and high school life science educators that target the science and ethics of translational research, 2) Provide learning experiences for students that will increase their understanding of translational research and ethics, and 3) Disseminate the resources and materials developed through the CURE program. The following activities will be included: 1) A 'Biomedical Research-Science and Ethics' teacher professional development workshop that includes time with scientists in research facilities and discussions with individuals who review research protocols, 2) Development of a 'Research Integrity' curriculum for secondary schools focused on the research process and ethical standards that apply to scientific conduct, the use of animals in research, and human clinical trials, 3) A 'Biomedical Research Fellows' program for high school juniors from underrepresented minority backgrounds that provides laboratory visits, interactions with scientists, and a broad overview of the research process, 4) A 'Youth Ethics Summit' that brings together students of teachers who have participated in our professional development to participate in interactive discussions with ethicists and other students and to showcase projects related to bioethics. Dissemination in Phase II will be accomplished by the development of an online teacher course in collaboration with the University of Washington, workshops, and through the web via partners such as the American Institute of Biological Science's ActionBioscience site. Program evaluation will utilize both qualitative and quantitative research measures, including experimental and control groups to examine the impacts of the teacher professional development program on student learning. While members of the general public enjoy the vital health benefits of biomedical research, they are generally unaware of the process that generates new treatments and cures, or the ethical standards that help ensure that research is responsibly conducted. For example, there is considerable misunderstanding about how basic science relates to the development of drugs and therapies, why animals are needed, or how clinical trials are conducted. To ensure continued support for the research enterprise, it is necessary to promote understanding of the process of biomedical research and also to address its ethical considerations.