Frontiers in Cancer Research

癌症研究前沿

• 批准号: 10436202
• 负责人: Jeanne Ting Chowning
• 金额: $ 25.57万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10436202
• 关键词: Address; Bioethics; Biological; Biological Sciences; Biomedical Engineering; Biomedical Research; Bone Marrow Transplantation; CRISPR/Cas technology; Career Choice; Cessation of life; Clinical; Clinical Research; Clinical Trials; Communities; Companions; Development; Discipline; Disease; Education; Educational Curriculum; Educational process of instructing; Educational workshop; Engineering; Ethical Issues; Ethics; Fostering; Fred Hutchinson Cancer Research Center; Funding; Genetic Engineering; Goals; Health Resources; High School Student; Human; Immunotherapy; International; Knowledge; Laboratories; Learning; Malignant Neoplasms; Medical Research; Mentors; Modeling; Molecular and Cellular Biology; NCI Center for Cancer Research; National Institute of General Medical Sciences; Next Generation Science Standards; Plasmids; Program Development; Proteins; Randomized Controlled Trials; Research; Research Personnel; Resources; Role; School Teachers; Schools; Science; Scientist; Secondary Schools; Students; Teacher Professional Development; Training; Translating; Underrepresented Students; Underserved Population; United States National Institutes of Health; Viola; Visit; Washington; Work; Youth; anti-cancer; anticancer research; cancer immunotherapy; cancer therapy; career; curriculum development; design; efficacy evaluation; experience; follow-up; frontier; gene therapy clinical trial; interest; laboratory experience; learning materials; lens; novel strategies; outreach program; pedagogy; precision genetics; programs; science education; science teacher; skills; social; student training; teacher

PROJECT SUMMARY/ABSTRACT Frontiers in Cancer Research (“Frontiers”) is presented by the Science Education Partnership (SEP) at Fred Hutchinson Cancer Research Center (“Fred Hutch”). The Frontiers program is designed to meet two goals of the National Institutes of Health (NIH) and National Institute of General Medical Sciences (NIGMS): to increase the STEM content knowledge and pedagogical skills of teachers and to engage students, especially those from underserved populations, in basic and clinical medical research. Overall, Frontiers aims to increase public understanding of basic molecular and cellular biology, how this knowledge informs research questions, and how clinical research translates into cancer therapies and cures. More specifically, Frontiers focuses on exciting new NIH-funded research at Fred Hutch, such as immunotherapy, that promises to fundamentally change cancer treatment. The program will also explore the ethical implications of cancer research-related topics. Another goal is to introduce students, particularly those from backgrounds underrepresented in the biomedical sciences, to career possibilities in research. 1) Frontiers will engage secondary school students in basic molecular/cellular biology and cutting-edge cancer research by creating, piloting, and disseminating two Next Generation Science Standards (NGSS)-aligned cancer-focused curricular units (Project Violet: Anti-Cancer Molecules, Cancer Immunotherapy) and three different types of hands-on scientific kits (Protein Modeling and Cancer Treatment, Bioengineering Plasmid Design, and CRISPR/Cas9). The units, which will consist of 5-7 lessons to span 2-3 weeks, will also help students examine ethical issues related to genetic engineering, gene therapy, and clinical trials. We will use small randomized controlled trials to evaluate the efficacy of the developed curricular materials. 2) Frontiers will enhance the ability of secondary school life science teachers to teach fundamental biological principles and practices through the lens of cancer research by providing 20 teachers annually (Y2-Y5) with a 3-week summer professional development program that includes a mentored research experience, and 7 day- long sessions throughout the school year. 3) Frontiers aims to inspire secondary school students from underrepresented communities to pursue biomedical and clinical research careers. Our introductory school-year outreach program will bring 270 students annually to Fred Hutch to meet scientists and participate in Frontiers lessons held in dedicated Fred Hutch student training labs. We will also create and implement a model for scientists at Fred Hutch to visit classrooms to assist teachers with lessons and share their career paths with students.

项目摘要/摘要 癌症研究前沿(《前沿》)由弗雷德科学教育伙伴关系(SEP)主办 哈钦森癌症研究中心(“弗雷德·哈奇”)。边疆计划旨在满足以下两个目标 国家卫生研究院(NIH)和国家普通医学科学研究所(NIGMS)：增加 教师的STEM内容知识和教学技能，并吸引学生，特别是来自 在基础和临床医学研究方面，服务不足的人群。总体而言，Frontiers的目标是增加公众 了解基本的分子和细胞生物学，了解这些知识如何指导研究问题，以及 临床研究如何转化为癌症治疗和治愈。更具体地说，Frontiers专注于 由美国国立卫生研究院资助的弗雷德·哈奇的令人兴奋的新研究，如免疫疗法，有望从根本上 改变癌症的治疗方法。该计划还将探索与癌症研究相关的伦理影响 主题。另一个目标是介绍学生，特别是那些来自 生物医学科学，到在研究中的职业可能性。 1)Frontiers将让中学生学习基础分子/细胞生物学和前沿癌症 通过创建、试点和传播两个与下一代科学标准(NGSS)一致的研究 以癌症为重点的课程单元(紫罗兰计划：抗癌分子、癌症免疫治疗)和三个 不同类型的实践科学工具包(蛋白质建模和癌症治疗、生物工程质粒 设计和CRISPR/CAS9)。这些单元包括5-7节课，时间跨度为2-3周，这也将有所帮助 学生研究与基因工程、基因治疗和临床试验相关的伦理问题。我们将使用 评估开发的课程材料的疗效的小型随机对照试验。 2)前沿将提高中学生命科学教师教授基础生物学的能力 通过癌症研究的视角，每年为20名教师(Y2-Y5)提供 为期3周的暑期专业发展计划，包括指导研究经验和7天- 整个学年的课时都很长。 3)Frontiers旨在激励来自代表性不足社区的中学生 生物医学和临床研究职业。我们的介绍性学年外展计划将带来270 学生每年到弗雷德·哈奇与科学家见面，并参加在专门的弗雷德举办的前沿课程 哈奇学生培训实验室。我们还将创建和实施一个模型，供弗雷德·哈奇的科学家访问 课堂帮助教师授课，并与学生分享他们的职业道路。

项目成果

"We All Sort of Jump to That Relationship Piece": Science Teachers' Collaborative Professional Learning About the Role of Relationships in Argumentation.

“我们都会跳到那个关系部分”：科学教师关于关系在论证中的作用的协作专业学习。

• DOI: 10.1080/07370008.2023.2180006
• 发表时间: 2023
• 期刊: Cognition and instruction
• 影响因子: 3.3
• 作者: Chowning,JeanneTing

A new twist on DNA extraction: Collaborative argumentation and student protocol design.

DNA 提取的新变化：协作论证和学生协议设计。

• 发表时间: 2019
• 期刊: Science teacher (Normal, Ill.)
• 作者: Chowning,JeanneTing;Wu,Regina;Brinkema,Caren;Crocker,WendyDavis;Bass,Krystal;Lazerte,Debbie
• 通讯作者: Lazerte,Debbie