Pathways to Cancer Research Renewal

摘要 Pathways to Cancer Research Renewal（“Pathways Renewal”）是Pathways的更新。 癌症研究基金R25 CA 221770授予弗雷德哈钦森癌症研究 中心（“弗雷德哈奇”）在西雅图，华盛顿。它旨在实现国家的目标。 卫生研究院（NIH）和国家癌症研究所（NCI）扩大参与， 在科学中代表性不足的人群，从而增加科学的多样性 劳动力这次更新非常强调发展两个主要重点领域， 我们的路径计划-计算生物学和癌症健康不平等。这些领域 我们的学生确定了重要性，也是NCI/NIH的优先事项。我们将建立在 NCI通过YES R25对我们的科学教育工作进行了先前的投资 机制，引入新的和创新的组成部分，并加强我们现有的 为教育工作者和代表性不足的高中和本科生提供的途径计划 学生我们将开发和提供两个新的虚拟高中活动， 2021年应对大流行：一项外展计划，重点是使用计算 分析癌症数据集的工具，以及一个学年的学术研究实习。我们的目标是 该提案旨在：1）提供“哈奇教师奖学金”指导的多年研究 为中学科学教师提供经验，使他们能够编写课程材料 专注于计算生物学和癌症健康不平等; 2）扩大我们的“探索者”， “癌症编码”介绍性外展计划旨在增加符合条件的 对癌症研究、计算生物学和癌症健康感兴趣的青年 特别是不平等; 3）计算分析和社区的线程机会 在我们的“探索者虚拟学年”中， 实习”和“途径本科研究人员”指导，多年的研究 实习经历。在我们的计划中，我们非常重视发展 科学身份，培养对科学的归属感，并培养学生 向他们的家庭和社区传播科学。我们的综合和整体方法 建立在弗雷德哈奇科学教育的长期，强大的机构支持，我们的 参与和支持代表性不足的学生追求癌症的成功历史 研究事业，以及我们的科学教育工作人员和科学教师的力量。

ABSTRACT Pathways to Cancer Research Renewal (“Pathways Renewal”) is a renewal of the Pathways to Cancer Research grant R25 CA221770 awarded to Fred Hutchinson Cancer Research Center (“Fred Hutch”) in Seattle, Washington. It is designed to meet the goals of the National Institutes of Health (NIH) and National Cancer Institute (NCI) to broaden participation of underrepresented populations in science and thereby increase the diversity of the scientific workforce. This renewal places a strong emphasis on developing two major focus areas across our Pathways programs - computational biology and cancer health inequities. These areas of importance were identified by our students and are also priorities of NCI/NIH. We will build on the prior investments NCI has made in our science education efforts through the YES R25 mechanism, introducing new and innovative components and strengthening our existing Pathways programs for educators and underrepresented high school and undergraduate students. We will develop and offer two new virtual high school activities that were piloted in 2021 in response to the pandemic: an outreach program that focuses on using computational tools to analyze cancer datasets, and a school-year academic research internship. Our aims for this proposal are to: 1) Provide “Hutch Teacher Fellowship” mentored multi-year research experiences for secondary science teachers, preparing them to develop curriculum materials focused on computational biology and cancer health inequities; 2) Expand our “Explorers” and “Coding for Cancer” introductory outreach programs aimed at increasing the pool of eligible youth interested in cancer research in general, and computational biology and cancer health inequities in particular; and 3) Thread opportunities for computational analysis and community action related to cancer health inequities throughout our “Explorers Virtual School-Year Internship” and “Pathways Undergraduate Researchers” mentored, multi-year research internship experiences. Across our programs, we place a strong emphasis on the development of scientific identity, fostering a sense of belonging in science, and preparing students to communicate science to their families and communities. Our integrated and holistic approach builds on the long-standing, robust institutional support for science education at Fred Hutch, our successful history of engaging and supporting underrepresented students to pursue cancer research careers, and the strength of our science education staff and scientific faculty.