Pathways to Cancer Research Renewal

摘要 癌症研究途径的更新(“途径更新”)是对途径的更新 癌症研究资助R25 CA221770授予弗雷德·哈钦森癌症研究 华盛顿州西雅图的弗雷德·哈奇中心。它的设计是为了满足国家 卫生研究所(NIH)和国家癌症研究所(NCI)扩大参与 科学中代表性不足的人群，从而增加科学的多样性 劳动力。这次更新的重点是发展以下两个主要重点领域： 我们的路径计划-计算生物学和癌症健康不平等。这些地区 重要的是我们的学生确定的，也是NCI/NIH的优先事项。我们将在此基础上 NCI通过YES R25在我们的科学教育工作中所做的先前投资 机制，引入新的和创新的组件，并加强我们现有的 面向教育工作者和代表不足的高中和本科生的途径计划 学生们。我们将开发并提供两项新的虚拟高中活动，这两项活动在 2021年应对大流行：一项侧重于使用计算 分析癌症数据集的工具，以及一学年的学术研究实习。我们的目标是 这项建议是：1)提供“哈奇教师奖学金”指导的多年研究 中学科学教师的经验，为他们开发课程材料做好准备 专注于计算生物学和癌症健康不平等；2)扩大我们的“探索者”和 旨在增加符合条件的人群的“癌症编码”介绍性外展计划 对癌症研究、计算生物学和癌症健康感兴趣的年轻人 特别是不平等；以及3)计算分析和社区的线程机会 在我们的“探索者虚拟学年”中，与癌症健康不平等有关的行动 “实习”和“路径本科生研究人员”指导，多年研究 实习经历。在我们的项目中，我们非常重视发展 培养科学认同感，培养科学归属感，培养学生 向他们的家人和社区传播科学。我们的综合和整体方法 建立在弗雷德·哈奇对科学教育的长期、强有力的机构支持基础上，我们的 吸引和支持代表不足的学生从事癌症研究的成功历史 研究事业，以及我们的科学教育人员和科学教师的实力。

ABSTRACT Pathways to Cancer Research Renewal (“Pathways Renewal”) is a renewal of the Pathways to Cancer Research grant R25 CA221770 awarded to Fred Hutchinson Cancer Research Center (“Fred Hutch”) in Seattle, Washington. It is designed to meet the goals of the National Institutes of Health (NIH) and National Cancer Institute (NCI) to broaden participation of underrepresented populations in science and thereby increase the diversity of the scientific workforce. This renewal places a strong emphasis on developing two major focus areas across our Pathways programs - computational biology and cancer health inequities. These areas of importance were identified by our students and are also priorities of NCI/NIH. We will build on the prior investments NCI has made in our science education efforts through the YES R25 mechanism, introducing new and innovative components and strengthening our existing Pathways programs for educators and underrepresented high school and undergraduate students. We will develop and offer two new virtual high school activities that were piloted in 2021 in response to the pandemic: an outreach program that focuses on using computational tools to analyze cancer datasets, and a school-year academic research internship. Our aims for this proposal are to: 1) Provide “Hutch Teacher Fellowship” mentored multi-year research experiences for secondary science teachers, preparing them to develop curriculum materials focused on computational biology and cancer health inequities; 2) Expand our “Explorers” and “Coding for Cancer” introductory outreach programs aimed at increasing the pool of eligible youth interested in cancer research in general, and computational biology and cancer health inequities in particular; and 3) Thread opportunities for computational analysis and community action related to cancer health inequities throughout our “Explorers Virtual School-Year Internship” and “Pathways Undergraduate Researchers” mentored, multi-year research internship experiences. Across our programs, we place a strong emphasis on the development of scientific identity, fostering a sense of belonging in science, and preparing students to communicate science to their families and communities. Our integrated and holistic approach builds on the long-standing, robust institutional support for science education at Fred Hutch, our successful history of engaging and supporting underrepresented students to pursue cancer research careers, and the strength of our science education staff and scientific faculty.