Frontiers in Cancer Research

癌症研究前沿

• 批准号: 10204043
• 负责人: Jeanne Ting Chowning
• 金额: $ 14.83万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10204043
• 关键词: Address; Bioethics; Biological; Biological Sciences; Biomedical Engineering; Biomedical Research; Bone Marrow Transplantation; CRISPR/Cas technology; Career Choice; Cessation of life; Clinical; Clinical Research; Clinical Trials; Communities; Companions; Development; Discipline; Disease; Education; Educational Curriculum; Educational process of instructing; Educational workshop; Engineering; Ethical Issues; Ethics; Fostering; Fred Hutchinson Cancer Research Center; Funding; Genetic Engineering; Goals; Health Resources; High School Student; Human; Immunotherapy; International; Knowledge; Laboratories; Learning; Malignant Neoplasms; Medical Research; Mentors; Modeling; Molecular and Cellular Biology; NCI Center for Cancer Research; National Institute of General Medical Sciences; Next Generation Science Standards; Plasmids; Program Development; Proteins; Randomized Controlled Trials; Research; Research Personnel; Resources; Role; School Teachers; Schools; Science; Scientist; Secondary Schools; Students; Teacher Professional Development; Training; Translating; Underrepresented Students; Underserved Population; United States National Institutes of Health; Viola; Visit; Washington; Work; Youth; anti-cancer; anticancer research; cancer immunotherapy; cancer therapy; career; curriculum development; design; efficacy evaluation; experience; follow-up; frontier; gene therapy clinical trial; interest; laboratory experience; learning materials; lens; novel strategies; outreach program; pedagogy; precision genetics; programs; science education; science teacher; skills; social; student training; teacher

PROJECT SUMMARY/ABSTRACT Frontiers in Cancer Research (“Frontiers”) is presented by the Science Education Partnership (SEP) at Fred Hutchinson Cancer Research Center (“Fred Hutch”). The Frontiers program is designed to meet two goals of the National Institutes of Health (NIH) and National Institute of General Medical Sciences (NIGMS): to increase the STEM content knowledge and pedagogical skills of teachers and to engage students, especially those from underserved populations, in basic and clinical medical research. Overall, Frontiers aims to increase public understanding of basic molecular and cellular biology, how this knowledge informs research questions, and how clinical research translates into cancer therapies and cures. More specifically, Frontiers focuses on exciting new NIH-funded research at Fred Hutch, such as immunotherapy, that promises to fundamentally change cancer treatment. The program will also explore the ethical implications of cancer research-related topics. Another goal is to introduce students, particularly those from backgrounds underrepresented in the biomedical sciences, to career possibilities in research. 1) Frontiers will engage secondary school students in basic molecular/cellular biology and cutting-edge cancer research by creating, piloting, and disseminating two Next Generation Science Standards (NGSS)-aligned cancer-focused curricular units (Project Violet: Anti-Cancer Molecules, Cancer Immunotherapy) and three different types of hands-on scientific kits (Protein Modeling and Cancer Treatment, Bioengineering Plasmid Design, and CRISPR/Cas9). The units, which will consist of 5-7 lessons to span 2-3 weeks, will also help students examine ethical issues related to genetic engineering, gene therapy, and clinical trials. We will use small randomized controlled trials to evaluate the efficacy of the developed curricular materials. 2) Frontiers will enhance the ability of secondary school life science teachers to teach fundamental biological principles and practices through the lens of cancer research by providing 20 teachers annually (Y2-Y5) with a 3-week summer professional development program that includes a mentored research experience, and 7 day- long sessions throughout the school year. 3) Frontiers aims to inspire secondary school students from underrepresented communities to pursue biomedical and clinical research careers. Our introductory school-year outreach program will bring 270 students annually to Fred Hutch to meet scientists and participate in Frontiers lessons held in dedicated Fred Hutch student training labs. We will also create and implement a model for scientists at Fred Hutch to visit classrooms to assist teachers with lessons and share their career paths with students.

项目概要/摘要 癌症研究前沿（“前沿”）由弗雷德里克大学科学教育合作伙伴关系 (SEP) 提出 哈钦森癌症研究中心（“Fred Hutch”）。 Frontiers 计划旨在实现以下两个目标： 美国国立卫生研究院 (NIH) 和国立普通医学科学研究所 (NIGMS)：增加 教师的 STEM 内容知识和教学技能，并吸引学生，特别是来自不同国家的学生 基础和临床医学研究中服务不足的人群。总体而言，Frontiers 旨在增加公众 了解基本分子和细胞生物学，这些知识如何指导研究问题，以及 临床研究如何转化为癌症疗法和治愈方法。更具体地说，Frontiers 专注于 Fred Hutch 的 NIH 资助的令人兴奋的新研究，例如免疫疗法，有望从根本上 改变癌症治疗。该计划还将探讨癌症研究相关的伦理影响 主题。另一个目标是介绍学生，特别是那些来自在该领域代表性不足的背景的学生。 生物医学科学，研究职业的可能性。 1) Frontiers 将让中学生学习基础分子/细胞生物学和前沿癌症 通过创建、试点和传播两个符合下一代科学标准 (NGSS) 的研究 以癌症为重点的课程单元（紫罗兰计划：抗癌分子、癌症免疫疗法）和三个 不同类型的实践科学套件（蛋白质建模和癌症治疗、生物工程质粒 设计和 CRISPR/Cas9）。这些单元将包含 5-7 节课程，为期 2-3 周，也将有助于 学生研究与基因工程、基因治疗和临床试验相关的伦理问题。我们将使用 小型随机对照试验来评估所开发课程材料的功效。 2) Frontiers将提升中学生命科学教师教授基础生物学的能力 每年为 20 名教师（Y2-Y5）提供癌症研究视角的原则和实践 为期 3 周的夏季专业发展计划，包括指导研究经验和 7 天的 整个学年的长时间课程。 3) Frontiers 旨在激励来自代表性不足社区的中学生追求 生物医学和临床研究职业。我们的介绍性学年外展计划将带来 270 学生每年都会到 Fred Hutch 会见科学家并参加专门在 Fred Hutch 举办的前沿课程 哈奇学生培训实验室。我们还将创建并实施一个模型，供 Fred Hutch 的科学家参观 课堂上协助教师上课并与学生分享他们的职业道路。