Afferent Mechanisms of Pelvic Hypersensitivity
盆腔过敏的传入机制
基本信息
- 批准号:8335201
- 负责人:
- 金额:$ 58.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-09-19 至 2015-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAreaAttenuatedBehavioralBladderCNS processingChronicColorectalCutaneousDevelopmentDiseaseElectric StimulationExhibitsFecesFrequenciesFunctional disorderGastroenterologistGynecologistHabitsHyperalgesiaHypersensitivityInflammationInflammatoryIntestinesIrritable Bowel SyndromeLocal AnestheticsLocal anesthesiaMaintenanceMusNerveNeuronsNociceptorsOrganPainPain DisorderPathologyPathway interactionsPatientsPelvic PainPelvisPersonsProcessRectal AdministrationRecurrenceRelative (related person)ResearchRoleSigns and SymptomsSpinal GangliaStimulusStretchingSymptomsTimeTissuesUrologistVisceralVisceral AfferentsVisceral painWomanchronic abdominal painchronic painintravesicalnerve supplypainful bladder syndromerectalresearch studyresponse
项目摘要
DESCRIPTION (provided by applicant): Persons with chronic abdominal and pelvic pain disorders comprise a large proportion of patients seeking relief from gastroenterologists, urologists and gynecologists. Two common pelvic disorders, painful bladder syndrome (PBS) and irritable bowel syndrome (IBS), are characterized by altered bladder/bowel habits (e.g., urge, frequency and, in IBS, stool consistency), pain and hypersensitivity. These patients typically exhibit significantly lower response thresholds to provocative stimuli (e.g., cystometry, rectal distension), complain of increased sensitivity during normal organ function, and exhibit increased tenderness in areas of somatic referral which, in addition, are expanded in size. Interestingly, PBS and IBS exist in the absence of an apparent pathobiological cause and are thus characterized as 'functional.' It is widely assumed that functional disorders reflect altered CNS processing, but considerable evidence suggests that persistent afferent drive contributes significantly to the recurrent, unexplained pain and hypersensitivity that characterize them. The objective of this proposal is to determine the mechanisms by which pain and hypersensitivity arise and is maintained as a necessary step in developing better informed and more successful management strategies. The Aims include: 7 Aim 1: characterize the proportions of mechano-sensitive and insensitive afferents in electrophysiological experiments in the both the lumbar splanchnic and pelvic nerve innervations of the bladder and colorectum. 7 Aim 2: evaluate organ hypersensitivity in behavioral experiments, after which the proportions of bladder and colorectal mechanically insensitive afferents (MIAs) will be determined in bladder and colorectum removed from hypersensitive mice. We hypothesize the proportions of MIAs will be significantly reduced in organs from hypersensitive mice relative to normal controls. 7 Aim 3: identify the 'chemotypes' of mechano-sensitive and insensitive bladder and colorectal dorsal root ganglion neurons in both the lumbar splanchnic and pelvic nerve pathways. We hypothesize that there are significant differences in chemotype between MIAs and mechanosensitive afferents as well as between different mechanosensitive afferents and, further, between organs.
描述(由申请人提供):患有慢性腹部和盆腔疼痛疾病的患者中有很大一部分是寻求胃肠科医生、泌尿科医生和妇科医生缓解的患者。两种常见的盆腔疾病,膀胱疼痛综合征(PBS)和肠易激综合征(IBS),其特征在于改变的膀胱/肠道习惯(例如,急迫性、频率和IBS中的大便粘稠度)、疼痛和超敏反应。这些患者通常对刺激性刺激表现出显著较低的反应阈值(例如,膀胱测压、直肠扩张),抱怨在正常器官功能期间敏感性增加,并且在躯体参照区域表现出增加的压痛,此外,所述躯体参照区域在尺寸上扩大。有趣的是,PBS和IBS在没有明显病理生物学原因的情况下存在,因此被表征为“功能性的”。“人们普遍认为,功能性疾病反映了中枢神经系统处理的改变,但大量证据表明,持续的传入驱动对反复发作的、无法解释的疼痛和超敏反应有显著影响。本提案的目的是确定疼痛和超敏反应产生的机制,并将其作为制定更明智和更成功的管理策略的必要步骤。这些目标包括:7目标1:在膀胱和结肠直肠的腰内脏神经和盆神经支配的电生理实验中表征机械敏感和不敏感传入的比例。7目标2:在行为实验中评估器官超敏性,之后将在从超敏小鼠移除的膀胱和结肠直肠中确定膀胱和结肠直肠机械不敏感传入(MIA)的比例。我们假设相对于正常对照,过敏小鼠器官中MIA的比例将显著降低。7目标3:在腰内脏神经和骨盆神经通路中识别机械敏感和不敏感的膀胱和结直肠背根神经节神经元的“化学型”。我们假设,有显着差异的化学型之间的MIA和mechanosensitive传入,以及不同的mechanosensitive传入,进一步,器官之间。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Gerald F Gebhart其他文献
Gerald F Gebhart的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Gerald F Gebhart', 18)}}的其他基金
Training in Mechanisms and Clinical Presentation of Pain
疼痛机制和临床表现培训
- 批准号:
8695921 - 财政年份:2013
- 资助金额:
$ 58.13万 - 项目类别:
Training in Mechanisms and Clinical Presentation of Pain
疼痛机制和临床表现培训
- 批准号:
8668172 - 财政年份:2012
- 资助金额:
$ 58.13万 - 项目类别:
Training in Mechanisms and Clinical Presentation of Pain
疼痛机制和临床表现培训
- 批准号:
8435329 - 财政年份:2012
- 资助金额:
$ 58.13万 - 项目类别:
Training in Mechanisms and Clinical Presentation of Pain
疼痛机制和临床表现培训
- 批准号:
8267132 - 财政年份:2012
- 资助金额:
$ 58.13万 - 项目类别:
Pittsburgh Center for Pain Research Recruitment of a New Faculty Member
匹兹堡疼痛研究中心招聘新教员
- 批准号:
7861169 - 财政年份:2009
- 资助金额:
$ 58.13万 - 项目类别:
Pittsburgh Center for Pain Research Recruitment of a New Faculty Member
匹兹堡疼痛研究中心招聘新教员
- 批准号:
7933978 - 财政年份:2009
- 资助金额:
$ 58.13万 - 项目类别:
Predoctoral Training in the Pharmacological Sciences
药理学博士前培训
- 批准号:
6748874 - 财政年份:2004
- 资助金额:
$ 58.13万 - 项目类别:
相似国自然基金
层出镰刀菌氮代谢调控因子AreA 介导伏马菌素 FB1 生物合成的作用机理
- 批准号:2021JJ40433
- 批准年份:2021
- 资助金额:0.0 万元
- 项目类别:省市级项目
寄主诱导梢腐病菌AreA和CYP51基因沉默增强甘蔗抗病性机制解析
- 批准号:32001603
- 批准年份:2020
- 资助金额:24.0 万元
- 项目类别:青年科学基金项目
AREA国际经济模型的移植.改进和应用
- 批准号:18870435
- 批准年份:1988
- 资助金额:2.0 万元
- 项目类别:面上项目
相似海外基金
Onboarding Rural Area Mathematics and Physical Science Scholars
农村地区数学和物理科学学者的入职
- 批准号:
2322614 - 财政年份:2024
- 资助金额:
$ 58.13万 - 项目类别:
Standard Grant
TRACK-UK: Synthesized Census and Small Area Statistics for Transport and Energy
TRACK-UK:交通和能源综合人口普查和小区域统计
- 批准号:
ES/Z50290X/1 - 财政年份:2024
- 资助金额:
$ 58.13万 - 项目类别:
Research Grant
Wide-area low-cost sustainable ocean temperature and velocity structure extraction using distributed fibre optic sensing within legacy seafloor cables
使用传统海底电缆中的分布式光纤传感进行广域低成本可持续海洋温度和速度结构提取
- 批准号:
NE/Y003365/1 - 财政年份:2024
- 资助金额:
$ 58.13万 - 项目类别:
Research Grant
Point-scanning confocal with area detector
点扫描共焦与区域检测器
- 批准号:
534092360 - 财政年份:2024
- 资助金额:
$ 58.13万 - 项目类别:
Major Research Instrumentation
Collaborative Research: Scalable Manufacturing of Large-Area Thin Films of Metal-Organic Frameworks for Separations Applications
合作研究:用于分离应用的大面积金属有机框架薄膜的可扩展制造
- 批准号:
2326714 - 财政年份:2024
- 资助金额:
$ 58.13万 - 项目类别:
Standard Grant
Collaborative Research: Scalable Manufacturing of Large-Area Thin Films of Metal-Organic Frameworks for Separations Applications
合作研究:用于分离应用的大面积金属有机框架薄膜的可扩展制造
- 批准号:
2326713 - 财政年份:2024
- 资助金额:
$ 58.13万 - 项目类别:
Standard Grant
Unlicensed Low-Power Wide Area Networks for Location-based Services
用于基于位置的服务的免许可低功耗广域网
- 批准号:
24K20765 - 财政年份:2024
- 资助金额:
$ 58.13万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
RAPID: Collaborative Research: Multifaceted Data Collection on the Aftermath of the March 26, 2024 Francis Scott Key Bridge Collapse in the DC-Maryland-Virginia Area
RAPID:协作研究:2024 年 3 月 26 日 DC-马里兰-弗吉尼亚地区 Francis Scott Key 大桥倒塌事故后果的多方面数据收集
- 批准号:
2427233 - 财政年份:2024
- 资助金额:
$ 58.13万 - 项目类别:
Standard Grant
Postdoctoral Fellowship: OPP-PRF: Tracking Long-Term Changes in Lake Area across the Arctic
博士后奖学金:OPP-PRF:追踪北极地区湖泊面积的长期变化
- 批准号:
2317873 - 财政年份:2024
- 资助金额:
$ 58.13万 - 项目类别:
Standard Grant
RAPID: Collaborative Research: Multifaceted Data Collection on the Aftermath of the March 26, 2024 Francis Scott Key Bridge Collapse in the DC-Maryland-Virginia Area
RAPID:协作研究:2024 年 3 月 26 日 DC-马里兰-弗吉尼亚地区 Francis Scott Key 大桥倒塌事故后果的多方面数据收集
- 批准号:
2427232 - 财政年份:2024
- 资助金额:
$ 58.13万 - 项目类别:
Standard Grant