Analysis of Serum Exosomes in Patients with Colorectal and Breast Cancer

结直肠癌和乳腺癌患者血清外泌体分析

• 批准号: 8340437
• 负责人: Robert J. Coffey
• 金额: $ 6.24万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-23 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8340437
• 关键词: Advanced Malignant Neoplasm; Age; Biological Markers; Cancer Patient; Colorectal Cancer; Detection; Diagnosis; Disease; Epidermal Growth Factor Receptor; Galectin 3; Goals; Health; Human; Individual; Ligands; Malignant Neoplasms; Measures; Methods; Patients; Pilot Projects; Plasma; Population; Predictive Value; Proteins; Race; Relative (related person); Research Project Grants; Role; Serum; Staging; Study of serum; The Vanderbilt-Ingram Cancer Center at the Vanderbilt University; Work; base; cancer health disparity; interest; malignant breast neoplasm; outcome forecast; prognostic; response; sex; tumor

A major strength of this proposal is the blending of the complementary expertise of the two labs in breast and colorectal cancer with a shared interest in exosomes, enabling the formation of a true partnership to establish a clinically applicable method to measure selected proteins in exosomes from the serum of cancer patients. We anticipate that the reliable detection and precise quantification of selected proteins in serum exosomes may enable the eariier diagnosis of patients with breast and colorectal cancer. However, the pilot project will establish normal standards for serum exosomes in normal individuals, and then, initially, compare these results to patients with early and advanced colorectal cancer and advanced breast cancer. As the work progresses, analysis of serum exosomes may prove to have prognostic and predictive value in the management of patients with cancer [1].

这项建议的一个主要优点是融合了两者的互补专长 乳腺癌和结直肠癌的实验室与外泌体的共同利益，使真正的 合作建立一种临床适用的方法，以测量来自 癌症患者的血清。我们预计，可靠的检测和精确的定量选择 血清外泌体中的蛋白质可以使乳腺癌和结肠直肠癌患者的早期诊断成为可能。 不过，该试点项目将建立正常个体血清外泌体的正常标准，然后， 首先，将这些结果与早期和晚期结直肠癌以及晚期乳腺癌患者进行比较， 癌随着工作的进展，血清外泌体的分析可能被证明具有预后和预测性 对癌症患者的治疗价值[1]。