Bioinformatics Core

生物信息学核心

• 批准号: 8072432
• 负责人: Bernard A Rosner
• 金额: $ 23.05万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-28 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8072432
• 关键词: Basic Science; Bioinformatics; Cancer Center; Clinical Medicine; Data Collection; Data Set; Development; Ensure; Epidemiology; Grant; Individual; Lead; Leadership; Measurement; Measures; Methodology; Methods; Obesity; Obesity associated cancer; Phenotype; Pilot Projects; Research; Research Activity; Research Personnel; Statistical Methods; System; T-Cell Receptor-Rearrangement Excision DNA Circles; Training Activity; Work; data sharing; improved; meetings; member; multilevel analysis; novel; programs; sound

Core Summary: The Bioinformatics Core aims to provide statistical expertise and programming support via a transdisciplinary approach during the implementation of projects 1 to 4, as well as during TREC pilot studies. The specific aims are: 1). To provide statistical and methodological support to the Harvard TREC Center, and develop new methods of answering research questions raised by the Center; 2). To interface epidemiology, basic sciences, and clinical medicine, and ensure that sound statistical methods are incorporated into all research and training activities at the TREC Center; 3). To manage and maintain large data sets appropriate for use in secondary epidemiologic analyses regarding obesity and energetic issues, and for developing and refining measures of obesity and cancer-related phenotypes; and 4). To ensure timely sharing of data and their submission for centralized data collection at the Coordinating Center. Under the leadership of Dr. Bernard Rosner, Core members will meet monthly to review statistical and measurement issues across the projects. Members will participate in the annual retreat with presentations on state-of-the-art statistical methodology systems and multilevel analysis. Individual statisticians will meet regularly with the research teams they support and with the lead investigators of each developmental project. The Bioinformatics team has worked closely with all Project Leaders in developing the statistical methods and power calculations described in the proposals. The Core will actively participate in transdisciplinary research as an integral part ofthe TREC Center and will develop new methods (or apply existing methods in novel ways across projects), with a particular focus of working with pilot study recipients and new investigators.

核心摘要： 生物信息学核心旨在通过跨学科方法在项目1至4的实施期间以及在TREC试点研究期间提供统计专业知识和方案编制支持。具体目标是：1）。为哈佛TREC中心提供统计和方法支持，并开发新的方法来回答中心提出的研究问题; 2）。将流行病学、基础科学和临床医学结合起来，并确保将合理的统计方法纳入TREC中心的所有研究和培训活动; 3）。管理和维护大型数据集，适用于有关肥胖和能量问题的二次流行病学分析，并用于开发和改进肥胖和癌症相关表型的测量;以及4）。确保及时共享数据并提交给协调中心进行集中数据收集。在Bernard Rosner博士的领导下，核心成员将每月举行会议，审查各项目的统计和测量问题。成员将参加年度务虚会，介绍最先进的统计方法系统和多层次分析。个别统计人员将定期与他们所支持的研究小组和每个发展项目的主要调查员会晤。生物信息学团队与所有项目负责人密切合作，开发提案中描述的统计方法和功效计算。核心将积极参与跨学科研究，作为TREC中心的一个组成部分，并将开发新的方法（或以新的方式在项目中应用现有方法），特别关注与试点研究接受者和新研究者的合作。