CTSA INFRASTRUCTURE FOR AIDS RESEARCH

本分项目是CTSA供资的估计百分比，即 被用于广泛的研究领域(艾滋病研究、儿科研究或 临床试验)。列出的总成本仅是对CTSA金额的估计 用于这一研究领域的基础设施，而不是由 授予子项目或子项目工作人员的NCRR补助金。 描述(由申请人提供)：耶鲁大学临床调查中心(YCCI)是为培训下一代临床研究人员提供“家”而创建的。主要的计划目标是：1)吸引医学、护理、公共卫生、生物科学和生物医学工程领域的优秀学生和初级教师；培训他们使用最先进的研究工具；赋予他们在复杂研究团队中工作的技能；支持他们的专业发展；以及2)促进将与疾病有关的发现从实验室转化为临床和社区，方法是：鼓励创建跨学科团队；提供最先进的核心设施和扩大生物统计和生物信息学资源；为临床研究建立组织和监管基础设施；并建立新的伙伴关系，将社区领导人、医生和健康中心整合在一起，并鼓励参与研究。参与的机构包括医学院、护理和公共卫生学院、生物医学工程系以及生物和生物医学科学研究生课程。初级学院学者奖励计划和研究医学计划(IMP)是YCCI教育和培训工作的核心。IMP是一个独特的博士项目，为从事翻译或临床研究的高资质医学博士研究员提供健康科学研究博士学位，初级教师学者项目是一个职业发展项目。YCCI还创建了一个导师协会，积极参与YCCI学者的培训和培养。试点和可行性(P&F)赠款将用于：1)跨学科翻译团队研究；2)新方法的开发；3)核心(包括成像)技术的使用；以及4)基于社区的研究。YCCI将围绕共同的主题聚集研究核心，包括：成像；基因组和蛋白质组学；基于细胞和组织的技术；综合代谢；认知和生物行为；以及动物模型。研究服务厅将为监管、生物统计、生物信息学、招聘和其他支助服务提供强大的设施和资源。YCCI将有一个办公室来协调大学解决我们社区和我们国家社区面临的健康问题的努力。 公共卫生相关性(由申请人提供)：这项研究与公共卫生直接相关，因为它的目标是促进临床研究，包括通过培训下一代临床研究人员，从而导致更好的人类疾病治疗和更好的健康结果。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): The Yale Center for Clinical Investigation (YCCI) was created to provide a "home" for training the next generation of clinical investigators. Key programmatic goals are to 1) attract highly talented students and junior faculty across medicine, nursing, public health, biological sciences and biomedical engineering; and train them in the use of state-of-the-art research tools; give them the skills to work within complex research teams; and support their professional development; and 2) foster the translation of disease-related discoveries from the laboratory into the clinic and then the community by: stimulating the creation of interdisciplinary teams; making available state-of-the-art core facilities and expanded biostatistical and bioinformatics resources; establishing organizational and regulatory infrastructure for clinical studies; and forging new partnerships that will integrate community leaders, physicians, and health centers and encourage participation in research. Participating institutions include the Schools of Medicine, Nursing, and Public Health, the department of Biomedical Engineering and the Graduate Programs in Biological and Biomedical Sciences. The Junior Faculty Scholars award program and the Investigative Medicine program (IMP) are central to YCCI's education and training efforts. IMP is a unique doctoral program that offers Ph.D. degrees in Health Sciences Research to highly qualified M.D. fellows embarking on careers in translational or clinical research and the junior faculty scholars program is a career development program. YCCI has also created a Society of Mentors who participates actively in the training and nurturing of the YCCI Scholars. Pilot and feasibility (P&F) grants will be awarded for: 1) interdisciplinary translational team research; 2) development of novel methodologies; 3) Use of Core (incl imaging) technologies; and 4) community-based research. YCCI will cluster research cores around common themes, including: imaging; genomics and proteomics; cell and tissue based tech; Integrated metabolics; cognition and biobehavior; and animal models. The Office of Research Services will provide robust facilities and resources for regulatory, biostatistical, bioinformatics, recruitment and other support services. YCCI will have an office to coordinate the University's efforts to address health issues facing our community and our national community. PUBLIC HEALTH RELEVANCE (provided by applicant): This research has direct relevance to public health in that its goals are to facilitate clinical research, including by training the next generation of clinical researchers that will lead to better treatments for human disease and better health outcomes.