Yale Clinical and Translational Science Award

耶鲁临床与转化科学奖

• 批准号: 9309129
• 负责人: ROBERT S SHERWIN
• 金额: $ 839.81万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9309129
• 关键词: Achievement; Applied Research; Area; Award; Beds; Bioethics; Bioinformatics; Biological; Biometry; Biotechnology; Budgets; Child; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Services; Clinical Trials; Collaborations; Communities; Community Health; Connecticut; Data; Data Analyses; Diagnostic; Discipline of Nursing; Disease; Drug Industry; Education; Elderly; Engineering; Environment; Faculty; Fostering; Foundations; Funding; Grant; Growth; Health Benefit; Healthcare Systems; Home environment; Hospitals; Individual; Industry; Informatics; Inpatients; Interdisciplinary Study; K-Series Research Career Programs; Leadership; Link; Longevity; Medical; Medical center; Medicine; Movement; NCI Scholars Program; Nurses; Outcome Study; Outpatients; Paper; Patient Recruitments; Patients; Physicians; Population; Population Heterogeneity; Public Health; Publishing; Recommendation; Records; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Research Subject Recruitments; Schools; Science; Scientist; Strategic Planning; Students; System; Talents; Technology Transfer; Therapeutic; Training; Translational Research; Translations; United States National Institutes of Health; Universities; Visit; Woman; Work; Workforce Development; base; career; career development; clinical infrastructure; clinical investigation; disorder prevention; health care delivery; innovation; innovative technologies; medical schools; medical specialties; member; multidisciplinary; next generation; novel; programs; protocol development; research facility; skills; success; tool; translational scientist; underserved minority

Contact PD/PI: Sherwin, Robert S. 1. Overall Project Summary- The Yale Center for Clinical Investigation (YCCI) was created in 2005 to strengthen Yale's infrastructure for clinical and translational research, based on the recommendation of a Medical School strategic planning committee. Soon afterwards, when NIH launched its new program of Clinical & Translational Science Awards, YCCI applied and became the home of the Yale CTSA. Since then, one of its major priorities has been to support the education and career development of the next generation of clinical and translational investigators. As described in the present application, this initiative has met with great success, underscored by the fact that graduates of YCCI's K-Scholar program have received 47 individual NIH K Awards, 43 NIH RO1 awards, and 65 Foundation grants, published >1,800 papers, and obtained >$240 million in independent research funding. Remarkably, 98% of the program's graduates have stayed in academic medicine or pursued research careers in the biotech or pharmaceutical industries. YCCI has also made substantial progress in its push to accelerate the translation of disease-related discoveries into the clinic. As will be described, it provides Yale investigators with key assistance in areas including biostatistics and bioinformatics, study design, protocol development, regulatory approval, patient recruitment, access to inpatient and outpatient research facilities, and budgeting support, and gives them ready access to pilot grants and state-of-the-art research cores. The result has been a significant upsurge in the number and scope of clinical research projects throughout the Medical Center. In the next grant cycle, YCCI will build upon these achievements with an emphasis on team-based T1 to T4 research, including studies across the lifespan. YCCI will also pursue new partnerships with the Yale School of Engineering & Applied Science to develop an innovative technology transfer program called the Center for Biological and Innovative Technology (CBIT) and with the School of Organization & Management to offer a novel program of leadership training for clinicians and physician-scientists. In addition, YCCI will take active advantage of the recent expansion of clinical services by Yale-New Haven Hospital (YNHH), which now has 1,540 beds and more than 1 million outpatients visits per year, and the growth of the Yale Medical Group (YMG), which has a network of >1,200 practicing physicians in >100 clinical specialties. The resulting clinical volume (~4 million patient records) gives Yale researchers access to a large, diverse patient base for outcomes studies and clinical trials. Overall, YCCI will leverage Yale's outstanding scientific and clinical environment and work with other CTSA hubs to foster the growth of multidisciplinary team science, to develop innovative strategies for disease prevention, diagnostics, and therapeutics, and to implement results for the benefit of the health care system and the population as a whole. Project Summary/Abstract Page 220 Contact PD/PI: Sherwin, Robert S. Program Narrative Yale Center for Clinical Investigation (YCCI) is a leader in team-based T1 to T4 research, including studies across the lifespan. YCCI will leverage Yale University's outstanding scientific and clinical environment and work with other CTSA hubs to foster the growth of multidisciplinary team science, to develop innovative strategies for disease prevention, diagnostics, and therapeutics, and to implement results for the benefit of the health care system and the population as a whole.

联系PD/PI：Sherwin，Robert S. 1。总体 项目摘要 - 耶鲁大学临床调查中心（YCCI）于2005年创建了耶鲁大学 根据医学院的建议，用于临床和转化研究的基础设施 战略计划委员会。此后不久，NIH启动了新的临床和翻译计划 科学奖，YCCI申请并成为耶鲁CTSA的故乡。从那时起，它的主要优先事项之一 一直支持下一代临床和翻译的教育和职业发展 调查人员。如本应用程序中所述，该计划取得了巨大成功，突显了 YCCI的K-Scholar计划的毕业生已获得47个个人NIH K奖，43个NIH RO1奖和65个基金会赠款，发表> 1,800篇论文，获得了> 2.4亿美元 研究资金。值得注意的是，该计划的98％的毕业生一直呆在学术医学或从事学术医学领域 生物技术或制药行业的研究职业。 YCCI在其上也取得了重大进展 推动将与疾病相关的发现转化为诊所。如描述的那样，它提供了 耶鲁大学的调查员在包括生物统计学和生物信息学，研究设计，方案在内的领域有关键帮助 开发，监管批准，招聘患者，进入住院和门诊研究设施， 和预算支持，并使他们可以随时获得飞行员赠款和最先进的研究核心。这 结果在整个临床研究项目的数量和范围中都大大提高 医疗中心。 在下一个赠款周期中，YCCI将基于这些成就，重点是基于团队的T1至T4 研究，包括整个生命周期的研究。 YCCI还将与耶鲁学校建立新的合作伙伴关系 工程和应用科学开发了一个创新的技术转移计划，称为中心 生物学和创新技术（CBIT）以及组织与管理学院提供 针对临床医生和医师科学家的领导力培训的新颖计划。此外，YCCI将活跃 YNEW Haven Hospital（YNHH）最近扩大临床服务的优势，现在 每年1,540张床和超过100万个门诊病人和耶鲁医疗集团的增长 （YMG），该网络在> 100个临床专业中拥有> 1200名执业医师的网络。由此产生的临床 数量（约400万名患者记录）使耶鲁大学的研究人员获得了大型，多样化的患者基础的机会 结果研究和临床试验。总体而言，YCCI将利用耶鲁大学的杰出科学和临床 环境并与其他CTSA枢纽合作，以促进多学科团队科学的发展，以发展 预防疾病，诊断和治疗学的创新策略，并实施结果 卫生保健系统和整个人口的好处。 项目摘要/摘要页面220 联系PD/PI：Sherwin，Robert S. 程序叙述 耶鲁大学临床调查中心（YCCI）是基于团队T1至T4研究的领导者，包括研究 整个生命周期。 YCCI将利用耶鲁大学的杰出科学和临床环境以及 与其他CTSA枢纽合作，以促进多学科团队科学的发展，开发创新 预防疾病，诊断和治疗策略，并实施结果 医疗保健系统和整个人口。