Diabetes Endocrinology Research Center

糖尿病内分泌研究中心

• 批准号: 7980521
• 负责人: ROBERT S SHERWIN
• 金额: $ 33.1万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-04 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7980521
• 关键词: Animal Genetics; Animal Model; Animals; Area; Biochemistry; Biological; Biology; Biomedical Engineering; Biophysics; Cellular biology; Clinical; Clinical Investigator; Core Facility; Development; Developmental Biology; Diabetes Mellitus; Diagnostic radiologic examination; Discipline of obstetrics; Endocrine System Diseases; Endocrinology; Environment; Funding; Goals; Gynecology; Immunobiology; Institution; Internal Medicine; Laboratories; Metabolic; Metabolic Diseases; Metabolism; Molecular; Molecular Biology; Molecular Genetics; Neurology; Orthopedic Surgery procedures; Outcome; Pathogenesis; Pathology; Patients; Pediatrics; Pharmacology; Physiology; Prevention strategy; Productivity; Psychiatry; Psychology; Public Health Nurses; Public Health Nursing; Research; Research Activity; Research Infrastructure; Research Personnel; Research Training; Resources; Scientist; Techniques; Testing; Time; Training; Transgenic Animals; Translating; Universities; Ursidae Family; Work; animal resource; base; bench to bedside; catalyst; design; diabetes risk; diabetic patient; innovation; interest; medical schools; member; multidisciplinary; neurosurgery; novel; operation; prevent; programs; tool; treatment strategy

The Yale Diabetes Endocrinology Research Center was established in the Spring of 1993 with the goal of promoting research in diabetes and related metabolic and endocrine disorders at the University. The Center brings together a multidisciplinary group of nearly 100 member scientists as well as professional supporting staff, new investigators and research trainees from the Departments of Internal Medicine, Pediatrics, Immunobiology, Biology, Cell Biology, Molecular Biophysics and Biochemistry, Bioengineering, Genetics, Molecular, Cellular and Developmental Biology, Physiology, Pharmacology, Surgery, Orthopedics, Neurosurgery, Neurology, Psychiatry, Obstetrics and Gynecology, Diagnostic Radiology, Psychology, Pathology, Laboratory Medicine, and from the Schools of Public Health and Nursing and the Pierce Laboratory. The scope of the research activities of the membership is very broad, ranging from basic molecular biology to whole body physiology and the treatment of diabetic patients. The members, however, share a common interest in research that is related to diabetes, endocrinology and metabolism or is fundamental to understanding its pathogenesis or for the development of new treatment strategies. The design of the Yale DERC is aimed at developing an infrastructure that could serve as a catalyst to stimulate innovative research. The cornerstone of the Center is its six Research Cores that provide funded basic and clinical investigators with the opportunity to more efficiently utilize resources and expand the scope of their research programs. The Clinical Metabolism and the new Diabetes Translational Cores facilitate metabolic research in patients, whereas the Molecular, Transgenic, Animal Genetics, Animal Physiology and Cell Biology Cores that comprise the Animal Resource Program offer investigators the tools to create and test novel animal models starting from the molecule and ending with biological outcomes. The Administrative Core oversees the operation of the Center, its Pilot/Feasibility Project and Enrichment Programs, and helps to coordinate patient-based research in diabetes. The goals of the DERC are to: 1) stimulate multidisciplinary interactions, particularly between basic and clinical scientists; 2) efficiently organize time consuming and/or costly techniques through Core facilities to enhance the productivity of investigators conducting research in diabetes related areas; 3) promote new research programs through pilot feasibility projects; 4) enhance the quality of research training, and 5) create a stimulating institutional environment that enhances research efforts to develop new strategies to prevent and treat diabetes and related metabolic and endocrine disorders at the local and national level.

耶鲁大学糖尿病内分泌学研究中心成立于1993年春，旨在促进耶鲁大学在糖尿病及相关代谢和内分泌疾病方面的研究。该中心汇集了来自内科、儿科、免疫生物学、生物学、细胞生物学、分子生物物理学和生物化学、生物工程、遗传学、分子、细胞和发育生物学、生理学、药理学、外科、整形外科、神经外科、精神病学、精神病学、妇产科、诊断放射学、心理学、病理学、实验室医学、公共卫生和护理学院以及皮尔斯实验室的近100名成员科学家和专业支持人员、新研究人员和研究实习生。会员的研究活动范围非常广泛，从基础分子生物学到全身生理学和糖尿病患者的治疗。然而，成员们， 在与糖尿病、内分泌学和新陈代谢相关的研究中有共同的兴趣或 对了解其发病机制或开发新的治疗策略具有重要意义。这个 耶鲁大学DERC的设计旨在开发一种可以作为催化剂的基础设施，以刺激 创新研究。该中心的基石是其六个研究核心，这些核心提供资助的基础和 临床研究人员有机会更有效地利用资源并扩大其 研究项目。临床代谢与新的糖尿病转译核心促进代谢 患者研究，而分子、转基因、动物遗传学、动物生理学和细胞 构成动物资源计划的生物核心为研究人员提供了创建和测试的工具 新的动物模型从分子开始，以生物学结果结束。行政部门 CORE监督中心的运作及其试点/可行性项目和浓缩方案，并帮助 协调基于患者的糖尿病研究。DERC的目标是：1)刺激 多学科互动，特别是基础和临床科学家之间的互动；2)有效地组织时间 通过核心设施消耗和/或昂贵的技术来提高调查人员的工作效率 开展糖尿病相关领域的研究；3)通过试点可行性推动新的研究计划 项目；4)提高研究培训的质量；5)创造激励的体制环境， 加强研究工作，制定预防和治疗糖尿病及相关代谢和疾病的新策略 地方和国家层面的内分泌紊乱。