Yale Clinical and Translational Science Award

耶鲁临床与转化科学奖

• 批准号: 9563424
• 负责人: ROBERT S SHERWIN
• 金额: $ 33.5万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9563424
• 关键词: Achievement; Applied Research; Area; Award; Beds; Bioethics; Bioinformatics; Biological; Biometry; Biotechnology; Budgets; Child; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Services; Clinical Trials; Collaborations; Communities; Community Health; Connecticut; Data; Data Analyses; Diagnostic; Discipline of Nursing; Disease; Drug Industry; Education; Elderly; Engineering; Environment; Faculty; Fostering; Foundations; Funding; Grant; Growth; Health Benefit; Healthcare Systems; Home environment; Hospitals; Individual; Industry; Informatics; Inpatients; Interdisciplinary Study; K-Series Research Career Programs; Leadership; Link; Longevity; Medical; Medical center; Medicine; Movement; NCI Scholars Program; Nurses; Outcome Study; Outpatients; Paper; Patient Recruitments; Patients; Physicians; Population; Population Heterogeneity; Public Health; Publishing; Recommendation; Records; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Research Subject Recruitments; Schools; Science; Scientist; Strategic Planning; Students; System; Talents; Technology Transfer; Therapeutic; Training; Translational Research; Translations; United States National Institutes of Health; Universities; Visit; Woman; Work; Workforce Development; base; career; career development; clinical infrastructure; clinical investigation; disorder prevention; health care delivery; innovation; innovative technologies; medical schools; medical specialties; member; multidisciplinary; next generation; novel; programs; protocol development; research facility; skills; success; tool; translational scientist; underserved minority

Contact PD/PI: Sherwin, Robert S. 1. Overall Project Summary- The Yale Center for Clinical Investigation (YCCI) was created in 2005 to strengthen Yale's infrastructure for clinical and translational research, based on the recommendation of a Medical School strategic planning committee. Soon afterwards, when NIH launched its new program of Clinical & Translational Science Awards, YCCI applied and became the home of the Yale CTSA. Since then, one of its major priorities has been to support the education and career development of the next generation of clinical and translational investigators. As described in the present application, this initiative has met with great success, underscored by the fact that graduates of YCCI's K-Scholar program have received 47 individual NIH K Awards, 43 NIH RO1 awards, and 65 Foundation grants, published >1,800 papers, and obtained >$240 million in independent research funding. Remarkably, 98% of the program's graduates have stayed in academic medicine or pursued research careers in the biotech or pharmaceutical industries. YCCI has also made substantial progress in its push to accelerate the translation of disease-related discoveries into the clinic. As will be described, it provides Yale investigators with key assistance in areas including biostatistics and bioinformatics, study design, protocol development, regulatory approval, patient recruitment, access to inpatient and outpatient research facilities, and budgeting support, and gives them ready access to pilot grants and state-of-the-art research cores. The result has been a significant upsurge in the number and scope of clinical research projects throughout the Medical Center. In the next grant cycle, YCCI will build upon these achievements with an emphasis on team-based T1 to T4 research, including studies across the lifespan. YCCI will also pursue new partnerships with the Yale School of Engineering & Applied Science to develop an innovative technology transfer program called the Center for Biological and Innovative Technology (CBIT) and with the School of Organization & Management to offer a novel program of leadership training for clinicians and physician-scientists. In addition, YCCI will take active advantage of the recent expansion of clinical services by Yale-New Haven Hospital (YNHH), which now has 1,540 beds and more than 1 million outpatients visits per year, and the growth of the Yale Medical Group (YMG), which has a network of >1,200 practicing physicians in >100 clinical specialties. The resulting clinical volume (~4 million patient records) gives Yale researchers access to a large, diverse patient base for outcomes studies and clinical trials. Overall, YCCI will leverage Yale's outstanding scientific and clinical environment and work with other CTSA hubs to foster the growth of multidisciplinary team science, to develop innovative strategies for disease prevention, diagnostics, and therapeutics, and to implement results for the benefit of the health care system and the population as a whole. Project Summary/Abstract Page 220 Contact PD/PI: Sherwin, Robert S. Program Narrative Yale Center for Clinical Investigation (YCCI) is a leader in team-based T1 to T4 research, including studies across the lifespan. YCCI will leverage Yale University's outstanding scientific and clinical environment and work with other CTSA hubs to foster the growth of multidisciplinary team science, to develop innovative strategies for disease prevention, diagnostics, and therapeutics, and to implement results for the benefit of the health care system and the population as a whole.

联系PD/PI：Sherwin，Robert S. 1.整体而言 项目摘要-耶鲁大学临床调查中心(YCCI)成立于2005年，旨在加强耶鲁大学的 临床和转化性研究的基础设施，基于医学院的建议 战略规划委员会。不久之后，当美国国立卫生研究院推出了新的临床与翻译项目 科学奖，YCCI申请，并成为耶鲁CTSA的主场。从那时起，它的主要优先事项之一 一直在支持下一代临床和翻译人员的教育和职业发展 调查人员。如本申请书所述，这一举措取得了巨大成功，强调 YCCI的K学者项目的毕业生已经获得了47个NIH K奖，43个NIH RO1奖项和65项基金资助，发表了1800篇论文，获得了2.4亿美元的独立资金 研究经费。值得注意的是，该项目98%的毕业生留在了学术医学专业或继续深造 从事生物技术或制药行业的研究工作。YCCI在以下方面也取得了实质性进展 推动疾病相关发现加快转化为临床。如下所述，它提供了 耶鲁大学研究人员在生物统计学和生物信息学、研究设计、方案等领域提供关键协助 开发、监管批准、患者招募、住院和门诊研究设施的使用， 和预算支持，并使他们能够随时获得试点赠款和最先进的研究核心。这个 结果是临床研究项目的数量和范围在整个 医疗中心。 在下一个资助周期中，YCCI将在这些成就的基础上再接再厉，重点是基于团队的T1到T4 研究，包括整个生命周期的研究。YCCI还将寻求与耶鲁大学学院的新伙伴关系 工程与应用科学将开发一个创新的技术转让计划，名为 生物与创新技术(CBIT)和组织与管理学院提供 临床医生和内科科学家领导力培训的新方案。此外，YCCI还将积极 耶鲁-纽黑文医院(YNHH)最近扩大临床服务的优势，该医院现在拥有 每年1,540张床位和100多万门诊量，以及耶鲁医疗集团的增长 在100个临床专科拥有1200名执业医生的网络。由此产生的临床 数量(约400万份患者记录)使耶鲁大学的研究人员能够接触到庞大、多样化的患者基础 结果研究和临床试验。总体而言，YCCI将利用耶鲁大学杰出的科学和临床 环境和与其他CTSA中心合作，以促进多学科团队科学的发展，以发展 疾病预防、诊断和治疗的创新战略，并落实 卫生保健系统和整个人口的利益。 项目摘要/摘要页220 联系PD/PI：Sherwin，Robert S. 节目叙事 耶鲁大学临床调查中心(YCCI)是基于团队的T1到T4研究的领导者，包括研究 在整个生命周期内。YCCI将利用耶鲁大学卓越的科学和临床环境， 与其他CTSA中心合作，促进多学科团队科学的发展，开发创新 疾病预防、诊断和治疗战略，并落实成果，造福于 卫生保健系统和整个人口。