Yale Clinical and Translational Science Award

耶鲁临床与转化科学奖

• 批准号: 9563424
• 负责人: ROBERT S SHERWIN
• 金额: $ 33.5万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9563424
• 关键词: Achievement; Applied Research; Area; Award; Beds; Bioethics; Bioinformatics; Biological; Biometry; Biotechnology; Budgets; Child; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Services; Clinical Trials; Collaborations; Communities; Community Health; Connecticut; Data; Data Analyses; Diagnostic; Discipline of Nursing; Disease; Drug Industry; Education; Elderly; Engineering; Environment; Faculty; Fostering; Foundations; Funding; Grant; Growth; Health Benefit; Healthcare Systems; Home environment; Hospitals; Individual; Industry; Informatics; Inpatients; Interdisciplinary Study; K-Series Research Career Programs; Leadership; Link; Longevity; Medical; Medical center; Medicine; Movement; NCI Scholars Program; Nurses; Outcome Study; Outpatients; Paper; Patient Recruitments; Patients; Physicians; Population; Population Heterogeneity; Public Health; Publishing; Recommendation; Records; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Research Subject Recruitments; Schools; Science; Scientist; Strategic Planning; Students; System; Talents; Technology Transfer; Therapeutic; Training; Translational Research; Translations; United States National Institutes of Health; Universities; Visit; Woman; Work; Workforce Development; base; career; career development; clinical infrastructure; clinical investigation; disorder prevention; health care delivery; innovation; innovative technologies; medical schools; medical specialties; member; multidisciplinary; next generation; novel; programs; protocol development; research facility; skills; success; tool; translational scientist; underserved minority

Contact PD/PI: Sherwin, Robert S. 1. Overall Project Summary- The Yale Center for Clinical Investigation (YCCI) was created in 2005 to strengthen Yale's infrastructure for clinical and translational research, based on the recommendation of a Medical School strategic planning committee. Soon afterwards, when NIH launched its new program of Clinical & Translational Science Awards, YCCI applied and became the home of the Yale CTSA. Since then, one of its major priorities has been to support the education and career development of the next generation of clinical and translational investigators. As described in the present application, this initiative has met with great success, underscored by the fact that graduates of YCCI's K-Scholar program have received 47 individual NIH K Awards, 43 NIH RO1 awards, and 65 Foundation grants, published >1,800 papers, and obtained >$240 million in independent research funding. Remarkably, 98% of the program's graduates have stayed in academic medicine or pursued research careers in the biotech or pharmaceutical industries. YCCI has also made substantial progress in its push to accelerate the translation of disease-related discoveries into the clinic. As will be described, it provides Yale investigators with key assistance in areas including biostatistics and bioinformatics, study design, protocol development, regulatory approval, patient recruitment, access to inpatient and outpatient research facilities, and budgeting support, and gives them ready access to pilot grants and state-of-the-art research cores. The result has been a significant upsurge in the number and scope of clinical research projects throughout the Medical Center. In the next grant cycle, YCCI will build upon these achievements with an emphasis on team-based T1 to T4 research, including studies across the lifespan. YCCI will also pursue new partnerships with the Yale School of Engineering & Applied Science to develop an innovative technology transfer program called the Center for Biological and Innovative Technology (CBIT) and with the School of Organization & Management to offer a novel program of leadership training for clinicians and physician-scientists. In addition, YCCI will take active advantage of the recent expansion of clinical services by Yale-New Haven Hospital (YNHH), which now has 1,540 beds and more than 1 million outpatients visits per year, and the growth of the Yale Medical Group (YMG), which has a network of >1,200 practicing physicians in >100 clinical specialties. The resulting clinical volume (~4 million patient records) gives Yale researchers access to a large, diverse patient base for outcomes studies and clinical trials. Overall, YCCI will leverage Yale's outstanding scientific and clinical environment and work with other CTSA hubs to foster the growth of multidisciplinary team science, to develop innovative strategies for disease prevention, diagnostics, and therapeutics, and to implement results for the benefit of the health care system and the population as a whole. Project Summary/Abstract Page 220 Contact PD/PI: Sherwin, Robert S. Program Narrative Yale Center for Clinical Investigation (YCCI) is a leader in team-based T1 to T4 research, including studies across the lifespan. YCCI will leverage Yale University's outstanding scientific and clinical environment and work with other CTSA hubs to foster the growth of multidisciplinary team science, to develop innovative strategies for disease prevention, diagnostics, and therapeutics, and to implement results for the benefit of the health care system and the population as a whole.

联系人 PD/PI：Sherwin, Robert S. 1. 总体 项目概要 - 耶鲁大学临床研究中心 (YCCI) 成立于 2005 年，旨在加强耶鲁大学的临床研究 根据医学院的推荐，提供临床和转化研究的基础设施 战略规划委员会。不久之后，美国国立卫生研究院 (NIH) 推出了新的临床与转化项目 YCCI 申请了科学奖，并成为耶鲁 CTSA 的所在地。从那时起，其主要优先事项之一 一直致力于支持下一代临床和转化人员的教育和职业发展 调查人员。正如本申请所述，这一举措取得了巨大成功，并强调 YCCI K-Scholar 项目的毕业生已获得 47 项 NIH K 个人奖、43 项 NIH 奖 RO1 奖项和 65 项基金会资助，发表超过 1,800 篇论文，并获得超过 2.4 亿美元的独立资助 研究经费。值得注意的是，该项目 98% 的毕业生继续从事学术医学或继续深造 生物技术或制药行业的研究职业。 YCCI在这方面也取得了实质性进展 推动加速将疾病相关发现转化为临床。正如将要描述的，它提供 耶鲁大学研究人员在生物统计学和生物信息学、研究设计、方案等领域提供关键协助 开发、监管批准、患者招募、使用住院和门诊研究设施、 和预算支持，并让他们随时获得试点拨款和最先进的研究核心。这 结果是整个临床研究项目的数量和范围显着增加 医疗中心。 在下一个拨款周期中，YCCI 将在这些成就的基础上再接再厉，重点关注基于团队的 T1 至 T4 研究，包括整个生命周期的研究。 YCCI还将与耶鲁大学商学院建立新的合作伙伴关系 工程与应用科学开发一个名为“中心”的创新技术转让计划 生物与创新技术（CBIT）以及组织与管理学院提供 针对临床医生和医师科学家的领导力培训的新颖计划。此外，YCCI将积极采取 耶鲁纽黑文医院 (YNHH) 最近扩大临床服务的优势，该医院现在拥有 1,540张床位和每年超过100万人次的门诊量，以及耶鲁医疗集团的成长 (YMG)，拥有超过 100 个临床专业的超过 1,200 名执业医师网络。由此产生的临床 数量（约 400 万份患者记录）使耶鲁大学研究人员能够接触到庞大、多样化的患者基础， 结果研究和临床试验。总体而言，YCCI 将利用耶鲁大学杰出的科学和临床优势 环境并与其他 CTSA 中心合作，促进多学科团队科学的发展，开发 疾病预防、诊断和治疗的创新战略，并落实成果 医疗保健系统和全体人民的利益。 项目总结/摘要第 220 页 联系人 PD/PI：Sherwin, Robert S. 节目叙述 耶鲁临床研究中心 (YCCI) 是基于团队的 T1 至 T4 研究的领导者，包括研究 贯穿整个生命周期。 YCCI将利用耶鲁大学出色的科学和临床环境， 与其他 CTSA 中心合作，促进多学科团队科学的发展，开发创新 疾病预防、诊断和治疗的策略，并为了造福人类而实施结果 医疗保健系统和整个人口。