Clinical and Laboratory Research Training for Surgical Oncologists

描述(由申请人提供)：目前癌症研究中科学发现的快速步伐，特别是在细胞、基因组和分子水平上，为基础科学发现的快速临床应用提供了前所未有的机会。这一进展将通过向一批已经致力于学术领导的外科肿瘤学家提供严格的基础和临床研究培训来优化。该计划的具体目标是为这群精挑细选的个人提供正式的科学思想和技术培训。每年将有两名学员从正在接受广受欢迎的普通外科或胸科外科肿瘤学专科奖学金培训的学员中竞争性地挑选出来。遴选过程将确定并匹配最合格的申请者，而不考虑他们是内部候选人还是外部候选人。学员将选择进入实验室研究轨道或临床研究轨道。每个研究员将被指导从我们的参与教师名单中选择一名高级讲师/导师，他们都在实验室或临床癌症研究方面表现出杰出的成就，以及成功的见习导师的既定记录。正式的研究培训计划在住院医师后18个月的外科肿瘤学培训(我们的优先事项)或PG3年的外科住院医师培训之后开始，将持续2-3年。这一培训期间不受临床职责的干扰，包括研究伦理方面的正式培训以及根据个人兴趣和能力定制的额外必修课程工作。所有受训人员都被分配了一个单独的研究金委员会，负责批评受训人员的研究，监测朝着独立调查职业方向的长期进展，并帮助选择适当的课程工作。研究培训环境包括细胞和分子医学研究生计划，其中选定的受训人员可获得博士学位，以及临床调查研究生培训计划，在该计划中，可以攻读硕士或博士学位。由于我们的外科肿瘤学和胸外科教职员工中有广泛的女性和少数族裔代表，以及赠款中描述的积极主动的战略，这一计划加强了对代表性不足的少数族裔的具体招募。通过这种方式，该项目旨在培养一批高度精选的普通外科和胸科外科肿瘤学家，他们将开发原创的重要研究项目，并在整个外科和肿瘤学社区提供学术领导。 相关性：我们建议的培训计划旨在支持将在实验室或临床癌症研究领域从事职业生涯的年轻外科肿瘤学家的正式研究培训，因为他们正在为学术外科肿瘤学的领导角色做准备。这笔培训补助金将是国家向简化的外科肿瘤学家培训计划过渡的重要组成部分。

DESCRIPTION (provided by applicant): The current rapid pace of scientific discovery in cancer research, particularly at the cellular, genomic, and molecular levels, offers unprecedented opportunities for rapid clinical application of basic scientific findings. This progress will be optimized by providing rigorous basic and clinical research training to a select group of surgical oncologists who are already directed towards academic leadership. The Specific Aim of this program is to provide formal training in scientific thought and technique to this select group of individuals. Two trainees per year will be competitively selected among trainees pursuing highly sought-after subspecialty fellowship training in either General or Thoracic Surgical Oncology. The selection process will identify and match the most qualified applicant, without regard to whether they are an internal or an external candidate. Trainees will elect to enter either the Laboratory Research Track or the Clinical Research Track. Each fellow will be guided to choose a senior preceptor/mentor from our list of participating faculty, all of whom have demonstrated an outstanding record of achievement in either laboratory or clinical cancer research, as well as an established record of successful trainee mentorship. The formal research training program begins after the required 18 months of post-residency surgical oncology training (our priority) or after the PG3 year of surgical residency, and would last for 2-3 consecutive years. This training period is uninterrupted by clinical duties, and includes formal training in research ethics as well as additional mandatory course work tailored to individual interests and capabilities. All trainees are assigned an Individual Fellowship Committee charged with critiquing the trainee's research, monitoring long-term progress towards an independent investigative career, and aiding in the selection of appropriate course work. The research training environment includes the graduate program in Cellular and Molecular Medicine, in which selected trainees may be awarded Ph.D. degrees, as well as the Graduate Training Program in Clinical Investigation, in which either Masters or PhD programs may be pursued. The specific recruitment of underrepresented minorities to this program is enhanced by broad representation of women and minorities among our Surgical Oncology and Thoracic Surgery faculty and proactive strategies described in the grant. In this manner, the program is designed to generate a highly selected group of General and Thoracic Surgical Oncologists who will develop original and significant research programs and provide academic leadership throughout the surgical and oncologic communities. RELEVANCE: Our proposed training program seeks to support formal research training for young surgical oncologists who will pursue careers in either laboratory or clinical cancer research, as they prepare for leadership roles in academic surgical oncology. This training grant will be a vital component in the national transition to a streamlined training program for academic surgical oncologists.