Womens HIV Risk: Alcohol Intoxication and Sexual Victimization History

描述（由申请人提供）：拟议的项目是R 01 AA 016281的竞争性更新，并将继续研究调查饮酒，性受害史和STI/艾滋病毒相关的风险之间的关系在年轻成年女性的研究计划。最初的项目调查的影响，妇女的酒精中毒，性受害的历史，和合作伙伴的特点对妇女的艾滋病毒相关的性决策，通过两个酒精管理实验。现存的研究和原始项目的发现都表明，情绪和情绪调节结构可能在以下两个方面提供关键的解释性联系：1）性受害和增加的性风险行为; 2）饮酒和增加的性风险行为。然而，由于大部分现存的研究一直是描述性的和相关性的，很少有人知道情绪和情绪调节结构如何运作的时刻，影响妇女的性决策过程。此外，关于这些情绪因素如何介导或缓和酒精和性受害史对风险性决定的影响，我们所知甚少。本项目通过两种方法来解决这一知识差距：30天的每日日记评估和基于实验室的酒精管理实验。在完成筛选程序和在线基线调查后，年龄在21-30岁的性风险升高的女性（n = 600）将完成30天的每日日记评估，评估其情绪状态，情绪调节策略以及饮酒和性风险行为，以评估情绪状态，情绪调节，饮酒和风险性行为之间的日常关系。在完成每日日记期后，相同的参与者将完成一项实验室实验，评估酒精中毒和情绪环境对危险性意图的即时影响。广义估计方程将被用来研究日常的情绪状态和情绪调节策略对饮酒和性风险行为的影响。结构方程模型和其他基于回归的分析将被用来研究酒精中毒和实验操纵的情绪背景对性风险意图的实验影响。 公共卫生相关性：拟议的研究将促进我们对有和没有性受害史的女性中与艾滋病毒相关的决策和行为的情绪状态，情绪调节和酒精的日常和即时动态的理解。研究结果将大大告知预防方案的设计者，他们仍然对阻止艾滋病毒在妇女中传播的努力感到沮丧，并渴望了解新的和有希望的干预目标。从拟议的研究中收集到的信息可以用来设计艾滋病毒预防计划，这些计划适用于社交饮酒妇女，特别是那些有受害史的妇女，这是一个庞大但服务不足的人口。

DESCRIPTION (provided by applicant): The proposed project is a competing renewal of R01AA016281 and will continue a program of research investigating the relationships among alcohol consumption, sexual victimization history, and STI/HIV-related risk taking in young adult women. The original project investigated the influence of women's alcohol intoxication, sexual victimization history, and partner characteristics on women's HIV-related sexual decision making through two alcohol administration experiments. Both extant research and findings from the original project suggest that emotions and emotion regulation constructs may provide a key explanatory linkage between: 1) sexual victimization and increased sexual risk taking and 2) alcohol consumption and increased sexual risk taking. However, because the bulk of the extant research has been descriptive and correlational, little is known about how emotions and emotion regulation constructs operate in-the-moment to influence women's sexual decision-making processes. Moreover, even less is known about how these emotional factors may mediate or moderate the effects of alcohol and sexual victimization history on risky sexual decisions. The present project addresses this knowledge gap through two methods: a 30 day daily diary assessment and a laboratory-based alcohol administration experiment. After completing a screening procedure and an online baseline survey, women aged 21-30 of elevated sexual risk (n = 600) will complete a 30 day daily diary assessment of their emotional states, emotion regulation strategies, and their drinking and sexual risk behaviors in order to evaluate the daily relationships among emotional states, emotion regulation, alcohol consumption, and risky sexual behavior. Upon completion of the daily diary period, the same participants will complete an in-lab experiment assessing the in-the-moment effects of alcohol intoxication and emotional context on risky sexual intentions. Generalized estimating equations will be used to examine the daily influence of emotional states and emotion regulation strategies on alcohol consumption and sexual risk behavior. Structural equation modeling and other regression-based analyses will be used to examine the experimental effects of alcohol intoxication and experimentally- manipulated emotional context on sexual risk intentions. PUBLIC HEALTH RELEVANCE: The proposed research will advance our understanding of daily and in-the-moment dynamics of emotional states, emotion regulation, and alcohol on HIV-related decision-making and behavior in women with and without a history of sexual victimization. Findings will greatly inform designers of prevention programs, who remain frustrated in their efforts to stem the spread of HIV in women and eager to learn of new and promising targets for intervention. The information gleaned from the proposed studies could be used to design HIV prevention programs that work for social-drinking women, particularly those with a history of victimization, a substantial but underserved population.