The 2nd Biennial Science of Global Prostate Cancer Disparities in Black Men of Af

描述（由申请人提供）：尽管近年来美国总人口中前列腺癌（CaP）的发病率有所下降，但黑人男性的CaP死亡率是白人男性的两到三倍。迄今为止，人们对美国黑人男性与白人男性的CaP发病率差异知之甚少。进一步令人关切的是，关于加勒比、联合王国和西非其他黑人男子的CaP负担的文献越来越多。虽然黑人男性可能具有共同的遗传风险位点，导致CaP的发病率较高，但在生活在不同环境和文化中的黑人男性中观察到的风险变异性的病因学强调了对行为因素的贡献的强大和不断发展的认识，这些因素可能会改变这些生物风险因素。我们和其他人的初步观察表明，对我们来说，使用共同的方法和统一的工具研究黑人男性CaP的行为、环境和遗传决定因素是很重要的。因此，CaP科学家、临床医生和倡导者之间的全球合作对于了解CaP病因和制定有效解决CaP差异的干预措施非常重要。2010年8月27日至29日，第一届“全球黑人前列腺癌差异科学”两年一度的会议在佛罗里达州杰克逊维尔举行。在国家癌症研究所（R13 CA144439）的支持下，第一次会议取得了压倒性的成功。为了继续发展和维护我们的全球实践社区，本次会议拨款申请的目的是

DESCRIPTION (provided by applicant): Although the prostate cancer (CaP) incidence rates in the overall US population has declined in recent years, mortality from CaP is two to three times greater among Black men compared to White men. To date the disparate incidence of CaP in Black men in the US compared to their Caucasian counterparts is poorly understood. Of further concern is the growing literature on the burden of CaP among other Black men in the Caribbean, the United Kingdom and West Africa. Although Black men may share a common genetic risk locus contributing to the higher incidence of CaP, the etiology of the variability in risk observed among Black men living in varying environments and cultures highlights the strong and evolving knowledge of the contribution of behavioral factors that may modify these biological risk factors. Our preliminary observations and that of others point to the fact that it s important for us to study the behavioral, environmental and genetic determinants of CaP among Black men using common methodologies and uniform instruments. Global collaborations among CaP scientists, clinicians and advocates are thus important to understand CaP etiology and develop interventions that will effectively address CaP disparities. In 2010, the 1st biennial conference on "The Science of Global Prostate Cancer Disparities in Black Men" was held in Jacksonville Florida, August 27 -29, 2010. Supported by the National Cancer Institute (R13 CA144439), the first conference was an overwhelming success. To continue to develop and maintain our global community of practice, the objective of this conference grant application is to bring CaP scientists, clinicians, survivors, and advocates together to share cross cutting CaP research issues and develop the next research priorities to achieve prostate health equity globally. The 2nd biennial conference will be held in The Bahamas from Nov 1 - 4, 2012. The theme for the 2012 conference is "The Global Burden of Prostate Cancer: Economic, Clinical and Humanistic Outcomes". PUBLIC HEALTH RELEVANCE: The 2nd Biennial conference on "The Science of Global Prostate Cancer Disparities in Black Men" is proposed to bring CaP scientists, clinicians, survivors, and advocates together to share cross cutting CaP research issues and develop the next research priorities to achieve prostate health equity globally.