Administrative Core

行政核心

• 批准号: 8555533
• 负责人: Diana L Miglioretti
• 金额: $ 21.93万
• 依托单位: KAISER FOUNDATION HEALTH PLAN OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-27 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8555533
• 关键词: Breast Cancer Detection; Budgets; Communication; Confidentiality; Leadership; National Cancer Institute; Progress Reports; Risk; Structure; base; community setting; dissemination research; meetings; programs

The program theme is to identify effective breast cancer screening strategies for women with diverse levels of breast cancer risk to maximize screening benefits while minimizing potential harms. Program aims follow the premise that breast cancer screening will be most effective when: guidelines are based on accurate risk estimates that are tied to the effectiveness and harms of screening tests; women and physicians are informed about screening test performance based on risk level; risk-based screening practices are equitable; and high-quality comparative effectiveness research results are disseminated into community practice. Program goals will be met through three complementary research projects and three shared resource cores. Project 1, Risk Assessment in Community Practice: Developing Better Models, will improve prediction of breast cancer and breast cancer subtypes among women of varying ages and race/ethnicity and evaluate whether predicted risk can be used to optimize screening outcomes. Project 2, Comparative Effectiveness of Imaging Strategies for Breast Cancer Screening in Community Practice, will characterize the performance of advanced imaging technologies and screening strategies according to age, race/ethnicity, breast density, and overall breast cancer risk. Project 3, Community-based Utilization of Breast Imaging Technologies, will assess risk-based screening in diverse populations and identify disparities in access and use of new technologies. The Administrative Core will support logistical requirements and facilitate communication and data sharing. The Biostatistics and Data Management Core will coordinate data collection, management, and analysis and will develop statistical methods. The Comparative Effectiveness Core will use simulation modeling to estimate long-term implications of different screening practices on population health. The program represents an integrated effort to improve screening with the overall aim of averting deaths from breast cancer while minimizing harms.

该计划的主题是为具有不同乳腺癌风险水平的女性确定有效的乳腺癌筛查策略，以最大限度地提高筛查益处，同时最大限度地减少潜在危害。方案目标遵循的前提是，乳腺癌筛查在以下情况下最有效：指导方针基于与筛查试验的有效性和危害相关的准确风险估计;妇女和医生了解基于风险水平的筛查试验性能;基于风险的筛查做法是公平的;高质量的比较有效性研究结果传播到社区实践中。计划目标将通过三个互补的研究项目和三个共享资源核心来实现。项目1，社区实践中的风险评估：开发更好的模型，将改善对不同年龄和种族/民族妇女乳腺癌和乳腺癌亚型的预测，并评估预测的风险是否可用于优化筛查结果。项目2，在社区实践中乳腺癌筛查成像策略的比较有效性，将根据年龄，种族/民族，乳腺密度和整体乳腺癌风险来描述先进成像技术和筛查策略的性能。项目3，以社区为基础的乳腺成像技术的利用，将评估不同人群中基于风险的筛查，并确定在获得和使用新技术方面的差距。行政核心将支持后勤需求，促进通信和数据共享。生物统计和数据管理核心将协调数据收集、管理和分析，并将开发统计方法。比较有效性核心将使用模拟建模来估计不同筛查实践对人群健康的长期影响。该计划代表了改善筛查的综合努力，其总体目标是避免乳腺癌死亡，同时尽量减少危害。