The UCLA Imaging Resource for Mouse Cancer Models

加州大学洛杉矶分校小鼠癌症模型成像资源

• 批准号: 8020092
• 负责人: ARION Xenofon CHATZIIOANNOU
• 金额: $ 41.02万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8020092
• 关键词: Animals; Autoradiography; Biology; Bioluminescence; Cancer Model; Caring; Collaborations; Data; Development; Diagnosis; Education; Environment; Exposure to; Fostering; Funding; Goals; Image; Lead; Methodology; Methods; Mus; Physicians; Positron-Emission Tomography; Postdoctoral Fellow; Principal Investigator; Procedures; Protocols documentation; Radiation; Research; Research Personnel; Research Project Grants; Research Support; Resources; Role; Services; Students; Study Subject; Technology; United States National Institutes of Health; X-Ray Computed Tomography; base; cancer diagnosis; cancer therapy; digital; human disease; improved; in vivo; new technology; pre-clinical research; programs; research study; response; tool

DESCRIPTION (provided by applicant): UCLA has a mature small animal imaging program based on micro-positron emission tomography, x-ray micro computed tomography, in-vivo bioluminescence and digital whole body autoradiography imaging. Central to this program, is our small animal imaging resource (SAIR), which provides service and support through a state of the art facility to more than 24 independent Principal Investigators funded through the NIH and other agencies. Most of the research projects of these investigators are focused in cancer diagnosis and therapy. In addition to this service component, the roles of the SAIR within the UCLA and the US environments are to: (a) educate students, post-doctoral scholars, physicians and other biology researchers from within and outside UCLA in the tools, technologies and applications of imaging, and (b) foster collaborations and develop new technologies and methodologies that will improve the quantitative capabilities of non-invasive imaging. These goals will hopefully lead to better understanding of human disease and might lead to better methods for diagnosis and treatment of cancer. As part of this SAIR proposal, besides the research support and education, two developmental projects are included, that should improve the quality and quantitative accuracy of the acquired data, while they reduce the impact from radiation exposure on the studied subjects. The first project will seek to standardize the animal handling and care part of the imaging protocol prior to, during and after the procedure, such that the animal's response is as uniform as possible. The second project seeks to estimate at first, secondly optimize and thirdly track the radiation exposure to the animal subjects throughout sequences of multiple imaging experiments that can last several months. Both these projects will greatly benefit not only the research experiments carried through the UCLA SAIR, but all preclinical research in the US.

描述(申请人提供)：加州大学洛杉矶分校拥有成熟的小动物成像程序，基于微正电子发射断层扫描、X射线微计算机断层扫描、体内生物发光和数字全身放射成像。该计划的核心是我们的小动物影像资源(SAIR)，它通过最先进的设施为24名由NIH和其他机构资助的独立首席调查人员提供服务和支持。这些研究人员的研究项目大多集中在癌症诊断和治疗方面。除了这一服务组成部分，SAIR在加州大学洛杉矶分校和美国环境中的作用是：(A)在成像工具、技术和应用方面对加州大学洛杉矶分校内外的学生、博士后学者、医生和其他生物学研究人员进行教育，以及(B)促进合作并开发新的技术和方法，以提高非侵入性成像的定量能力。这些目标有望导致更好地了解人类疾病，并可能导致更好的癌症诊断和治疗方法。作为SAIR提案的一部分，除了研究支持和教育外，还包括两个开发项目，这两个项目将提高所获得数据的质量和数量准确性，同时减少辐射暴露对研究对象的影响。第一个项目将寻求标准化成像协议中的动物处理和护理部分，以使动物的反应尽可能统一。第二个项目寻求通过一系列可能持续几个月的多个成像实验，首先估计、其次优化和第三次跟踪对动物受试者的辐射暴露。这两个项目不仅将极大地有利于通过加州大学洛杉矶分校进行的研究实验，而且将极大地惠及美国所有的临床前研究。

项目成果

A deformable atlas of the laboratory mouse.

• DOI: 10.1007/s11307-014-0767-7
• 发表时间: 2015-02
• 期刊: MOLECULAR IMAGING AND BIOLOGY
• 影响因子: 3.1
• 作者: Wang, Hongkai;Stout, David B.;Chatziioannou, Arion F.
• 通讯作者: Chatziioannou, Arion F.

Dual-energy attenuation coefficient decomposition with differential filtration and application to a microCT scanner.

微分滤波双能衰减系数分解及其在 microCT 扫描仪上的应用。

• DOI: 10.1088/0031-9155/55/4/016
• 发表时间: 2010
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Taschereau,R;Silverman,RW;Chatziioannou,AF
• 通讯作者: Chatziioannou,AF

MARS: a mouse atlas registration system based on a planar x-ray projector and an optical camera.

• DOI: 10.1088/0031-9155/57/19/6063
• 发表时间: 2012-10-07
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Wang H;Stout DB;Taschereau R;Gu Z;Vu NT;Prout DL;Chatziioannou AF
• 通讯作者: Chatziioannou AF

Synthesis of bulk-size transparent gadolinium oxide-polymer nanocomposites for gamma ray spectroscopy.

• DOI: 10.1039/c2tc00245k
• 发表时间: 2013-03-14
• 期刊: Journal of materials chemistry. C
• 作者: Cai W;Chen Q;Cherepy N;Dooraghi A;Kishpaugh D;Chatziioannou A;Payne S;Xiang W;Pei Q
• 通讯作者: Pei Q

Design and optimization of coin-shaped microreactor chips for PET radiopharmaceutical synthesis.

• DOI: 10.2967/jnumed.109.065946
• 发表时间: 2010-02
• 期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
• 作者: Elizarov AM;van Dam RM;Shin YS;Kolb HC;Padgett HC;Stout D;Shu J;Huang J;Daridon A;Heath JR
• 通讯作者: Heath JR