Photon Counting Detectors for Clinical k-edge CT

用于临床 k 边缘 CT 的光子计数探测器

• 批准号: 8298152
• 负责人: WILLIAM C BARBER
• 金额: $ 80.79万
• 依托单位: DXRAY, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-10 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8298152
• 关键词: Abdomen; Accounting; Address; Agreement; Algorithms; Anodes; Attenuated; Calcified; Calcium; Ceramics; Clinical; Computer Simulation; Contrast Media; Coupled; Custom; Data; Detection; Development; Diagnosis; Dimensions; Discrimination; Dose; Elements; Encapsulated; Evaluation; Feedback; Fibrosis; Floods; Floor; Gadolinium; Generations; Goals; Grant; Histocompatibility Testing; Human; Image; Imaging Phantoms; Imaging Techniques; Iodine; Length; Manufacturer Name; Marketing; Measures; Mechanics; Methods; Mind; Modeling; Neck; Noise; Output; Patients; Performance; Phase; Photons; Physiologic pulse; Polychlorinated Biphenyls; Positioning Attribute; Power Sources; Printing; Production; Property; Public Health; Radiation; Reading; Resolution; Risk; Roentgen Rays; Rotation; Running; Sampling; Scanning; Semiconductors; Shapes; Side; Simulate; Skin; Slice; Speed; Staging; System; Technology; Testing; Thick; Time; Tissue Differentiation; Tissues; Translating; Tube; Weight; Work; X-Ray Computed Tomography; base; bone; cold temperature; commercialization; data modeling; design; detector; gadolinium oxide; imaging modality; improved; millisecond; next generation; novel; operation; physical property; product development; prototype; public health relevance; radiologist; reconstruction; research study; response; simulation; simulation software; soft tissue; statistics; success; tumor

DESCRIPTION (provided by applicant): This fast track grant titled, "Photon Counting Detectors for Clinical k-edge CT" will enable DxRay to bring to market a customer-driven improved version of our CdTe-based photon- counting x-ray computed tomography (CT) detector with energy discrimination. These detectors have enabled significant improvements in CT imaging such as reduced patient dose while maintaining excellent image quality, enhanced tissue contrast, and material decomposition capabilities (tissue type identification). The overall goal is to bring to the CT marketplace a photon-counting energy-dispersive x-ray detector with energy discrimination for use in human x-ray CT imaging. So far we have demonstrated a first generation fast photon- counting x-ray imaging array which has a higher maximum output count rate (by more than an order of magnitude) than all others, and the arrays have been used to generate the first patient images to date. This first-generation system is capable of counting at over 5 W 106 counts per second per mm2 (cps/mm2) and has performed clinical scans at up to 300 mA of tube current, demonstrating both reduced dose and improved image quality in neck and abdomen studies. Our x-ray imaging arrays are completely vertically integrated and are compatible with all the existing gantries and x-ray tubes being used clinically. With feedback from our customers we have determined that there are two more performance enhancements required from our detector for the full commercialization of our technology. In the first year we will produce a fully functioning prototype of the second- generation photon-counting CT detector and demonstrate its performance with all the features our customers require. In the second and third year of the project we will, with feedback from our customers, produce the first production runs of the final product, with sufficient numbers of detectors to provide samples to our customers for testing in their clinical systems. This will allow for patient studies to be performed in existing gantries. We expect large commercial success with this product. This is due to the significant improvements to and advantages over existing detectors that our technology provides together with the widespread and increasing use of CT. The x-ray exposure in CT scanning has been of major concern for radiologists and physicists as the number of CT examinations has increased. Therefore, a method which reduces the patient dose in CT examinations will have a significant impact on public health. Our product addresses the need to reduce dose in CT. At the same time, improved tissue differentiation and material-specific identification is needed for better diagnosis. Our product addresses these needs by improving image quality by making use of the energy information contained in the individually counted x-rays at high flux, information that is currently not obtainable with the non photon-counting x-ray imaging arrays currently in use in multi-slice CT systems. PUBLIC HEALTH RELEVANCE: The overall goal of this proposal is to develop a photon counting CT detector with energy binning and read-out that is capable of producing energy resolved CT scan which can deliver less radiation dose and differentiate between tissue types. Photon counting detectors with energy binning can improve CT performance by counting and binning each x-ray detected.

描述(由申请者提供)：这项名为“临床K-EDGE CT的光子计数探测器”的快速通道赠款将使DxRay能够向市场推出客户驱动的具有能量歧视功能的基于CdTe的光子计数X射线计算机断层扫描(CT)探测器的改进版本。这些探测器显著改善了CT成像，例如减少了患者的剂量，同时保持了出色的图像质量、增强的组织对比度和材料分解能力(组织类型识别)。总的目标是向CT市场推出一种用于人体X射线CT成像的具有能量识别功能的光子计数能量色散X射线探测器。到目前为止，我们已经展示了第一代快速光子计数X射线成像阵列，它具有比所有其他阵列更高的最大输出计数率(超过一个数量级)，并且这些阵列已经用于生成迄今为止第一个患者图像。这一第一代系统的计数能力超过5W 106次/秒/mm2(cps/mm2)，并在高达300 mA的管电流下进行了临床扫描，显示出颈部和腹部研究中剂量的减少和图像质量的改善。我们的X射线成像阵列是完全垂直集成的，与临床上使用的所有现有机架和X射线管兼容。根据我们客户的反馈，我们已经确定，我们的探测器需要另外两个性能增强，才能使我们的技术完全商业化。在第一年，我们将生产第二代光子计数CT探测器的全功能原型，并展示其性能和客户所需的所有功能。在项目的第二年和第三年，我们将根据客户的反馈，生产出第一批最终产品，并配备足够数量的检测器，向客户提供样品，以便在他们的临床系统中进行测试。这将允许在现有的门架上进行患者研究。我们希望这种产品能取得巨大的商业成功。这是由于我们的技术对现有检测器的重大改进和优势，以及CT的广泛和日益广泛的使用。随着CT检查次数的增加，CT扫描中的X射线曝光一直是放射科医生和物理学家主要关注的问题。因此，一种减少CT检查中患者剂量的方法将对公众健康产生重大影响。我们的产品满足了减少CT剂量的需要。同时，为了更好地诊断，需要改进组织分化和材料特异性识别。我们的产品通过利用单独计数的高通量X射线中包含的能量信息来满足这些需求，这些信息是目前多层CT系统中使用的非光子计数X射线成像阵列目前无法获得的。 与公共卫生相关：这项提议的总体目标是开发一种具有能量存储和读出功能的光子计数CT探测器，能够产生能够提供较少辐射剂量和区分组织类型的能量分辨CT扫描。具有能量存储的光子计数探测器可以通过对检测到的每一条X射线进行计数和存储来提高CT性能。