Low Dose Rapid Scanning Slit Digital Mammography and Breast Tomosynthesis
低剂量快速扫描狭缝数字化乳腺X线摄影和乳腺断层合成
基本信息
- 批准号:9098644
- 负责人:
- 金额:$ 46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-06-01 至 2017-07-18
- 项目状态:已结题
- 来源:
- 关键词:AddressAlgorithmsAnodesBackBreastBreast Cancer DetectionCadaverChicagoClinicalCollaborationsCollimatorCustomDataDetectionDevelopmentDiagnosisDigital Breast TomosynthesisDigital MammographyDiscriminationDoseFloodsFloorGenerationsGeometryGoalsGrantGray unit of radiation doseHealthHistocompatibility TestingHumanImageImaging PhantomsIndividualIodineLightingMarketingMeasuresMethodsNoiseOutputPatientsPatternPerformancePhasePhotonsPolychlorinated BiphenylsPower SourcesProceduresProtocols documentationPublic HealthRadiationResolutionScanningSideSignal TransductionSpottingsStreamSystemTechnologyThickTimeTissue DifferentiationTissuesTranslatingTubeUniversitiesWorkX-Ray Computed Tomographyabsorptionattenuationbasebreast imagingcontrast imagingdata acquisitiondesigndetectorimaging modalityimaging systemimprovedinnovationnovelphoton-counting detectorprototypequantumradiologistreconstructionresponsescreeningsimulationstatisticssuccess
项目摘要
DESCRIPTION (provided by applicant): This fast track grant titled, "Low Dose Rapid Scanning Slit Digital Mammography and Breast Tomosynthesis" will enable us to bring to market a clinically driven improved method of breast imaging based on photon-counting x-ray detector arrays with energy discrimination. The detectors will enabled significant improvements in x-ray breast imaging such as reduced patient dose while maintaining excellent image quality, enhanced tissue contrast, material decomposition capabilities (tissue type identification), and quantitative iodine contrast imaging. The overall goal is to bring to the marketplace a photon-counting energy-dispersive x-ray detector with energy discrimination for use in human breast imaging. So far we have demonstrated a first generation fast photon-counting x-ray imaging array prototype which has a higher maximum output count rate (by more than an order of magnitude) than all others, and the array has been used to generate the preliminary data. Our technology is capable of counting at over 1 � 106 counts per second (cps) per 100 �m pixel which is 1 � 108 cps/mm2 and is the highest output count rate (OCR) measured to date with x-rays to our knowledge. Our x-ray imaging arrays are completely vertically integrated and can be tiled to large field of view. We use this technology to develop scanning slit breast imaging with multiple stacked 1D high flux energy resolved single photon counting detector arrays. For scanning slit digital mammography (DM) we have the advantage of energy information as compared to the currently available systems. Whereas for scanning slit digital breast tomosynthesis (DBT) we would have, in addition to energy information, scatter rejection from the multi-slit scanning. Building a system capable of both DM and DBT in a scanning slit mode offers the chance to achieve DM, DBT, and synthetic DM from DBT data all on one system. A gantry design will be used to sweep the detector slits across the FOV always close to and parallel to the compressed breast and always pointing to the focal spot for both DM (tube at 0�) and DBT (tube anywhere between �25�) so that the geometry of the projection images is the same as currently used in flat panel DM and BDT. The high OCR allows the use of a strong 50 mA x-ray tube to produce shorter scan times. The proposed photon counting x-ray detector based breast imaging will not only improve the quality of the current attenuation-based gray-scale images, but also open a door to completely new applications, new procedures, and new protocols, using the capabilities of tissue-type specific x-ray images. We expect large commercial success with this product. This is due to the significant improvements to and advantages over existing detectors that our technology provides together with the widespread and increasing use of breast imaging. The x-ray exposure in breast cancer screening has been of major concern for radiologists and physicists as the number of examinations has increased. Therefore, a method which reduces the patient dose in screening examinations will have a significant impact on public health. Our product addresses the need to reduce dose in breast imaging. At the same time, improved tissue differentiation and contrast specific identification is needed for better diagnosis. Our product addresses these needs by improving image quality by making use of the energy information contained in the individually counted x-rays at high flux, information that is currently not obtainable with the non photon-counting x-ray imaging arrays currently in use in breast imaging systems.
描述(由申请人提供):这项名为“低剂量快速扫描狭缝数字乳房x线摄影和乳房断层合成”的快速通道拨款将使我们能够将基于光子计数x射线探测器阵列的临床驱动的乳房成像改进方法推向市场。该探测器将显著改善乳房x射线成像,如降低患者剂量,同时保持良好的图像质量,增强组织对比度,材料分解能力(组织类型识别)和定量碘对比成像。总体目标是将具有能量识别功能的光子计数能量色散x射线探测器推向市场,用于人类乳房成像。到目前为止,我们已经展示了第一代快速光子计数x射线成像阵列原型,该阵列具有比所有其他阵列更高的最大输出计数率(超过一个数量级),并且该阵列已用于生成初步数据。我们的技术能够以每100 μ m像素超过1 μ 106次每秒(cps)的速度计数,即1 μ 108 cps/mm2,是迄今为止我们所知的用x射线测量的最高输出计数率(OCR)。我们的x射线成像阵列是完全垂直集成的,可以平铺到大视野。我们利用该技术开发了多层堆叠一维高通量能量分辨单光子计数探测器阵列的扫描狭缝乳房成像。对于扫描缝数字乳房x线照相术(DM),与目前可用的系统相比,我们具有能量信息的优势。而对于扫描缝数字乳房断层合成(DBT),除了能量信息外,我们还可以从多缝扫描中获得散射抑制。在扫描狭缝模式下构建一个同时支持DM和DBT的系统,可以在一个系统上实现DM、DBT和基于DBT数据的合成DM。一个龙门设计将用于扫描探测器的狭缝在视场总是接近和平行于压缩乳房,并始终指向焦点点DM(管在0°)和DBT(管之间的任何地方- 25°),使投影图像的几何形状是相同的,目前在平板DM和BDT中使用。高OCR允许使用强50 mA x射线管产生更短的扫描时间。所提出的基于光子计数x射线探测器的乳房成像不仅将提高当前基于衰减的灰度图像的质量,而且还将利用组织类型特定x射线图像的能力,为全新的应用、新程序和新协议打开一扇门。我们期望这个产品能取得巨大的商业成功。这是由于我们的技术对现有探测器的重大改进和优势,以及乳房成像的广泛和不断增加的使用。随着检查次数的增加,乳腺癌筛查中的x射线暴露一直是放射科医生和物理学家关注的主要问题。因此,在筛查检查中减少患者剂量的方法将对公众健康产生重大影响。我们的产品解决了乳腺成像中降低剂量的需求。同时,为了更好的诊断,需要更好的组织分化和对比特异性识别。我们的产品通过利用在高通量下单独计数的x射线中包含的能量信息来提高图像质量,从而满足了这些需求,这些信息目前在乳房成像系统中使用的非光子计数x射线成像阵列无法获得。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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WILLIAM C BARBER其他文献
WILLIAM C BARBER的其他文献
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{{ truncateString('WILLIAM C BARBER', 18)}}的其他基金
Low Dose Rapid Scanning Slit Digital Mammography and Breast Tomosynthesis
低剂量快速扫描狭缝数字化乳腺X线摄影和乳腺断层合成
- 批准号:
9738244 - 财政年份:2014
- 资助金额:
$ 46万 - 项目类别:
Low Dose Rapid Scanning Slit Digital Mammography and Breast Tomosynthesis
低剂量快速扫描狭缝数字化乳腺X线摄影和乳腺断层合成
- 批准号:
8644679 - 财政年份:2014
- 资助金额:
$ 46万 - 项目类别:
Photon Counting Detectors for Clinical k-edge CT
用于临床 k 边缘 CT 的光子计数探测器
- 批准号:
8298152 - 财政年份:2011
- 资助金额:
$ 46万 - 项目类别:
Simultaneous SPECT/CT with a single photon counting camera
使用单光子计数相机同时进行 SPECT/CT
- 批准号:
8200367 - 财政年份:2011
- 资助金额:
$ 46万 - 项目类别:
Photon Counting Detectors for Clinical k-edge CT
用于临床 k 边缘 CT 的光子计数探测器
- 批准号:
8180319 - 财政年份:2011
- 资助金额:
$ 46万 - 项目类别:
Photon Counting Detectors for Clinical k-edge CT
用于临床 k 边缘 CT 的光子计数探测器
- 批准号:
8001936 - 财政年份:2010
- 资助金额:
$ 46万 - 项目类别:
A Novel In-Vivo Cell Tracking System Based on Combined XCT and FT
基于 XCT 和 FT 组合的新型体内细胞追踪系统
- 批准号:
7327532 - 财政年份:2007
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$ 46万 - 项目类别:
A Novel In-Vivo Cell Tracking System Based on Combined XCT and FT
基于 XCT 和 FT 组合的新型体内细胞追踪系统
- 批准号:
7456659 - 财政年份:2007
- 资助金额:
$ 46万 - 项目类别:
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