Photon Counting Detectors for Clinical k-edge CT

用于临床 k 边缘 CT 的光子计数探测器

• 批准号: 8180319
• 负责人: WILLIAM C BARBER
• 金额: $ 84.69万
• 依托单位: DXRAY, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-10 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8180319
• 关键词: Abdomen; Accounting; Address; Agreement; Algorithms; Anodes; Attenuated; Calcified; Calcium; Ceramics; Clinical; Computer Simulation; Contrast Media; Coupled; Custom; Data; Detection; Development; Diagnosis; Dimensions; Discrimination; Dose; Elements; Encapsulated; Evaluation; Feedback; Fibrosis; Floods; Floor; Gadolinium; Generations; Goals; Grant; Histocompatibility Testing; Human; Image; Imaging Phantoms; Imaging Techniques; Iodine; Length; Manufacturer Name; Marketing; Measures; Mechanics; Methods; Mind; Modeling; Neck; Noise; Output; Patients; Performance; Phase; Photons; Physiologic pulse; Polychlorinated Biphenyls; Positioning Attribute; Power Sources; Printing; Production; Property; Public Health; Radiation; Reading; Resolution; Risk; Roentgen Rays; Rotation; Running; Sampling; Scanning; Semiconductors; Shapes; Side; Simulate; Skin; Slice; Speed; Staging; System; Technology; Testing; Thick; Time; Tissue Differentiation; Tissues; Translating; Tube; Weight; Work; X-Ray Computed Tomography; base; bone; cold temperature; commercialization; data modeling; design; detector; gadolinium oxide; imaging modality; improved; millisecond; next generation; novel; operation; physical property; product development; prototype; public health relevance; radiologist; reconstruction; research study; response; simulation; simulation software; soft tissue; statistics; success; tumor

DESCRIPTION (provided by applicant): This fast track grant titled, "Photon Counting Detectors for Clinical k-edge CT" will enable DxRay to bring to market a customer-driven improved version of our CdTe-based photon- counting x-ray computed tomography (CT) detector with energy discrimination. These detectors have enabled significant improvements in CT imaging such as reduced patient dose while maintaining excellent image quality, enhanced tissue contrast, and material decomposition capabilities (tissue type identification). The overall goal is to bring to the CT marketplace a photon-counting energy-dispersive x-ray detector with energy discrimination for use in human x-ray CT imaging. So far we have demonstrated a first generation fast photon- counting x-ray imaging array which has a higher maximum output count rate (by more than an order of magnitude) than all others, and the arrays have been used to generate the first patient images to date. This first-generation system is capable of counting at over 5 W 106 counts per second per mm2 (cps/mm2) and has performed clinical scans at up to 300 mA of tube current, demonstrating both reduced dose and improved image quality in neck and abdomen studies. Our x-ray imaging arrays are completely vertically integrated and are compatible with all the existing gantries and x-ray tubes being used clinically. With feedback from our customers we have determined that there are two more performance enhancements required from our detector for the full commercialization of our technology. In the first year we will produce a fully functioning prototype of the second- generation photon-counting CT detector and demonstrate its performance with all the features our customers require. In the second and third year of the project we will, with feedback from our customers, produce the first production runs of the final product, with sufficient numbers of detectors to provide samples to our customers for testing in their clinical systems. This will allow for patient studies to be performed in existing gantries. We expect large commercial success with this product. This is due to the significant improvements to and advantages over existing detectors that our technology provides together with the widespread and increasing use of CT. The x-ray exposure in CT scanning has been of major concern for radiologists and physicists as the number of CT examinations has increased. Therefore, a method which reduces the patient dose in CT examinations will have a significant impact on public health. Our product addresses the need to reduce dose in CT. At the same time, improved tissue differentiation and material-specific identification is needed for better diagnosis. Our product addresses these needs by improving image quality by making use of the energy information contained in the individually counted x-rays at high flux, information that is currently not obtainable with the non photon-counting x-ray imaging arrays currently in use in multi-slice CT systems. PUBLIC HEALTH RELEVANCE: The overall goal of this proposal is to develop a photon counting CT detector with energy binning and read-out that is capable of producing energy resolved CT scan which can deliver less radiation dose and differentiate between tissue types. Photon counting detectors with energy binning can improve CT performance by counting and binning each x-ray detected.

描述（由申请人提供）：这项名为“用于临床k-edge CT的光子计数检测器”的快速通道拨款将使DxRay能够将客户驱动的改进版本推向市场，该版本基于cdte的光子计数x射线计算机断层扫描（CT）检测器具有能量鉴别功能。这些检测器在CT成像方面有了显著的改进，例如在降低患者剂量的同时保持良好的图像质量，增强组织对比度和材料分解能力（组织类型识别）。总体目标是为CT市场带来一种用于人体x射线CT成像的光子计数能量色散x射线探测器。到目前为止，我们已经展示了第一代快速光子计数x射线成像阵列，该阵列具有比其他所有阵列更高的最大输出计数率（超过一个数量级），并且该阵列已用于生成迄今为止的第一批患者图像。第一代系统的计数速度超过5w，每秒每mm2 (cps/mm2) 106个计数，并在高达300 mA的管电流下进行临床扫描，在颈部和腹部研究中显示出剂量降低和图像质量提高。我们的x射线成像阵列是完全垂直集成的，与所有现有的临床使用的龙门架和x射线管兼容。根据客户的反馈，我们已经确定，为了使我们的技术完全商业化，我们的探测器还需要进行两项性能增强。在第一年，我们将生产一个功能齐全的第二代光子计数CT探测器的原型，并展示其性能与我们的客户需要的所有功能。在项目的第二年和第三年，我们将根据客户的反馈，生产最终产品的第一批生产，并提供足够数量的探测器，为客户提供样品，供他们在临床系统中测试。这将允许在现有的台架中进行患者研究。我们期望这个产品能取得巨大的商业成功。这是由于我们的技术提供了对现有探测器的重大改进和优势，以及CT的广泛和不断增加的使用。随着CT检查数量的增加，CT扫描中的x射线暴露一直是放射科医生和物理学家关注的主要问题。因此，在CT检查中减少患者剂量的方法将对公众健康产生重大影响。我们的产品解决了CT中降低剂量的需求。同时，为了更好的诊断，需要改进组织分化和材料特异性鉴定。我们的产品通过利用在高通量下单独计数的x射线中包含的能量信息来提高图像质量，从而满足了这些需求，这些信息目前在多层CT系统中使用的非光子计数x射线成像阵列无法获得。