Photon Counting Detectors for Clinical k-edge CT

用于临床 k 边缘 CT 的光子计数探测器

• 批准号: 8001936
• 负责人: WILLIAM C BARBER
• 金额: $ 39.77万
• 依托单位: DXRAY, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-20 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8001936
• 关键词: Abdomen; Accounting; Address; Agreement; Algorithms; Anodes; Attenuated; Calcified; Calcium; Ceramics; Clinical; Computer Simulation; Contrast Media; Coupled; Custom; Data; Detection; Development; Diagnosis; Dimensions; Discrimination; Dose; Elements; Encapsulated; Evaluation; Feedback; Fibrosis; Floods; Floor; Gadolinium; Generations; Goals; Grant; Histocompatibility Testing; Human; Image; Imaging Phantoms; Imaging Techniques; Iodine; Length; Manufacturer Name; Marketing; Measures; Mechanics; Methods; Mind; Modeling; Neck; Noise; Output; Patients; Performance; Phase; Photons; Physiologic pulse; Polychlorinated Biphenyls; Positioning Attribute; Power Sources; Printing; Production; Property; Public Health; Radiation; Reading; Resolution; Risk; Roentgen Rays; Rotation; Running; Sampling; Scanning; Semiconductors; Shapes; Side; Simulate; Skin; Slice; Speed; Staging; System; Technology; Testing; Thick; Time; Tissue Differentiation; Tissues; Translating; Tube; Weight; Work; X-Ray Computed Tomography; base; bone; cold temperature; commercialization; data modeling; design; detector; imaging modality; improved; millisecond; next generation; novel; operation; physical property; product development; prototype; public health relevance; radiologist; reconstruction; research study; response; simulation; simulation software; soft tissue; statistics; success; tumor

DESCRIPTION (provided by applicant): This fast track grant titled, "Photon Counting Detectors for Clinical k-edge CT" will enable DxRay to bring to market a customer-driven improved version of our CdTe-based photon- counting x-ray computed tomography (CT) detector with energy discrimination. These detectors have enabled significant improvements in CT imaging such as reduced patient dose while maintaining excellent image quality, enhanced tissue contrast, and material decomposition capabilities (tissue type identification). The overall goal is to bring to the CT marketplace a photon-counting energy-dispersive x-ray detector with energy discrimination for use in human x-ray CT imaging. So far we have demonstrated a first generation fast photon- counting x-ray imaging array which has a higher maximum output count rate (by more than an order of magnitude) than all others, and the arrays have been used to generate the first patient images to date. This first-generation system is capable of counting at over 5 W 106 counts per second per mm2 (cps/mm2) and has performed clinical scans at up to 300 mA of tube current, demonstrating both reduced dose and improved image quality in neck and abdomen studies. Our x-ray imaging arrays are completely vertically integrated and are compatible with all the existing gantries and x-ray tubes being used clinically. With feedback from our customers we have determined that there are two more performance enhancements required from our detector for the full commercialization of our technology. In the first year we will produce a fully functioning prototype of the second- generation photon-counting CT detector and demonstrate its performance with all the features our customers require. In the second and third year of the project we will, with feedback from our customers, produce the first production runs of the final product, with sufficient numbers of detectors to provide samples to our customers for testing in their clinical systems. This will allow for patient studies to be performed in existing gantries. We expect large commercial success with this product. This is due to the significant improvements to and advantages over existing detectors that our technology provides together with the widespread and increasing use of CT. The x-ray exposure in CT scanning has been of major concern for radiologists and physicists as the number of CT examinations has increased. Therefore, a method which reduces the patient dose in CT examinations will have a significant impact on public health. Our product addresses the need to reduce dose in CT. At the same time, improved tissue differentiation and material-specific identification is needed for better diagnosis. Our product addresses these needs by improving image quality by making use of the energy information contained in the individually counted x-rays at high flux, information that is currently not obtainable with the non photon-counting x-ray imaging arrays currently in use in multi-slice CT systems. PUBLIC HEALTH RELEVANCE: The overall goal of this proposal is to develop a photon counting CT detector with energy binning and read-out that is capable of producing energy resolved CT scan which can deliver less radiation dose and differentiate between tissue types. Photon counting detectors with energy binning can improve CT performance by counting and binning each x-ray detected.

描述（由申请人提供）：这项名为“临床 k 边缘 CT 的光子计数探测器”的快速拨款将使 DxRay 能够将我们基于 CdTe 的光子计数 X 射线计算机断层扫描 (CT) 探测器的客户驱动改进版本推向市场，该探测器具有能量辨别功能。这些探测器显着改进了 CT 成像，例如减少患者剂量，同时保持出色的图像质量、增强的组织对比度和材料分解能力（组织类型识别）。总体目标是为 CT 市场带来一款具有能量辨别功能的光子计数能量色散 X 射线探测器，用于人体 X 射线 CT 成像。到目前为止，我们已经展示了第一代快速光子计数 X 射线成像阵列，该阵列具有比所有其他阵列更高的最大输出计数率（高出一个数量级以上），并且该阵列已用于生成迄今为止第一批患者图像。该第一代系统能够以每毫米每秒超过 5 W 106 次计数 (cps/mm2) 的速度进行计数，并以高达 300 mA 的管电流进行临床扫描，证明颈部和腹部研究中的剂量减少并提高了图像质量。 我们的 X 射线成像阵列完全垂直集成，与临床使用的所有现有机架和 X 射线管兼容。 根据客户的反馈，我们确定探测器还需要两项性能增强才能使我们的技术全面商业化。第一年，我们将生产第二代光子计数 CT 探测器的功能齐全的原型，并展示其性能以及客户所需的所有功能。在项目的第二年和第三年，我们将根据客户的反馈，生产最终产品的第一批生产，并配备足够数量的探测器，为客户提供样品以在其临床系统中进行测试。这将允许在现有的机架中进行患者研究。 我们预计该产品将取得巨大的商业成功。这是由于我们的技术对现有探测器的显着改进和优势以及 CT 的广泛和不断增加的使用。随着 CT 检查数量的增加，CT 扫描中的 X 射线暴露已成为放射科医生和物理学家主要关注的问题。因此，一种减少患者CT检查剂量的方法将对公众健康产生重大影响。我们的产品满足了减少 CT 剂量的需求。与此同时，为了更好的诊断，需要改进组织分化和材料特异性识别。我们的产品通过利用高通量下单独计数的 X 射线中包含的能量信息来提高图像质量，从而满足这些需求，而目前多层 CT 系统中使用的非光子计数 X 射线成像阵列目前无法获得这些信息。 公共健康相关性：该提案的总体目标是开发一种具有能量分级和读出功能的光子计数 CT 探测器，能够产生能量分辨 CT 扫描，从而提供更少的辐射剂量并区分组织类型。具有能量分级功能的光子计数探测器可以通过对检测到的每条 X 射线进行计数和分级来提高 CT 性能。