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Core Grant for Vision Research

视觉研究核心资助

基本信息

批准号：
9769737
负责人：
David H Brainard
金额：
$ 75.93万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-09-01 至 2020-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9769737
关键词：
Affect Animal Model Basic Science Bioinformatics Biometry Blindness Cellular biology Clinical Research Collaborations Computer Simulation Conduct Clinical Trials Confocal Microscopy Core Grant Custom Data Analyses Development Disease Electrophysiology (science)Equipment Experimental Designs Eye Goals Grant Image Image Analysis In Vitro Individual Maintenance Methods Molecular Biology Molecular Genetics National Eye Institute Pennsylvania Physiology Primates Public Health Research Research Personnel Research Project Grants Resources Retinal Retinal Degeneration Savings Scientist Services Source Stimulus Tissues Universities Vision Vision Tests Vision research Visual Cortex Visual Pathways Visual Psychophysics Visual impairment Work awake cognitive neuroscience data acquisition design and construction gene therapy image processing imaging modality insight instrument instrumentation multi-electrode arrays programs public health relevance recruit repaired skills two-photon visual performance water maze

项目摘要

DESCRIPTION (provided by applicant): The broad goal of this proposal is to provide core support services for 21 Participating Investigators and over 30 Associate Investigators to: (1) enhance the quality and quantity of their research; (2) facilitate collaborations between investigators with different backgrounds and skills; and (3) recruit new investigators to vision research, help young vision investigators establish their labs, and allow established investigators to explore new directions. Participating Investigators hold 25 individual R01 research grants from the National Eye Institute, and Associate Investigators study vision but do not currently hold an R01 grant from the NEI. Collectively, the investigators represent a broad range of vision research, and include experts on animal models of retinal degeneration, retinal circuitry, gene therapy, cell and molecular biology, molecular genetics, eye, central visual pathways and cortical physiology, visual performance and cortical function in awake- behaving primates, cognitive neuroscience of vision, computational modeling, and visual psychophysics. The core grant will support 5 resource/service modules: Biostatistics provides expert assistance in experimental design and data analysis, particularly for clinical studies, as well as bioinformatics support; Image Analysis provides expert support for the development and implementation of image processing and analysis solutions, as well as other data analysis services; Imaging and Electrophysiology provides vision investigators access to shared equipment and technical support for a variety of imaging modalities and electrophysiological recording, including conventional and two-photon confocal microscopy, multi-electrode array recording from in vitro tissue, and spectral OCT imaging; Instrumentation provides for design and construction of custom stimulus delivery, data acquisition, and electrophysiological instruments that are unavailable from commercial sources, as well as maintenance and repair of such instruments; Noninvasive Assessment of Visual Function provides equipment and technical support for assessing visual function in animal models. Methods include ERG, pupillometry, and water maze testing of vision.