Purchase of IVC Caging Systems for Mice and Rats in Dunning Hall

描述（由申请人提供）：约翰霍普金斯大学（JHU）动物研究与资源副教务长办公室申请50万美元的财政支持，用于购买521,379美元的单独通风笼子（IVC）机架，用于在霍姆伍德校区克里格艺术与科学学院邓宁厅最近翻新的动物设施中饲养无特定病原体（SPF）大鼠和小鼠。Dunning Hall地下室的一部分在2009年冬天进行了翻新，创建了4个动物饲养室和1个程序/动物饲养室，以及一个笼子架冲洗室。其中两间动物饲养室将配备6-70笼Allentown单面IVC小鼠架，两间将配备6-40笼Allentown单面IVC大鼠架。程序/动物保存室可以放置两种类型的架子，如果将来需要的话，还可以放置一个生物安全柜用于动物程序。这些动物房间将用于饲养繁殖动物和研究前饲养的动物。动物将被转移、饲养和使用在利瓦伊大厅，该大厅通过一条地下隧道与邓宁大厅相连。这两名研究人员将使用20国集团拨款购买的笼子将动物安置在邓宁大厅设施中，直接花费的联邦资金总额近226万美元，其中188万美元来自美国国立卫生研究院。Dunning Hall的动物饲养能力的增加将允许Levi Hall的动物饲养空间用于支持校园内其他研究人员的研究项目，这些研究人员从NIH获得了560万美元的资助。

DESCRIPTION (provided by applicant): This application from the Office of the Associate Provost for Animal Research and Resources at Johns Hopkins University (JHU) requests $500,000 in financial support toward the total purchase price of $521,379 for individually ventilated cage (IVC) racks for housing specific pathogen free (SPF) rats and mice in a recently renovated animal facility in Dunning Hall at the Krieger College of Arts and Sciences at the Homewood Campus. A portion of the basement of Dunning Hall was renovated during the winter of 2009 to create 4 animal holding and 1 procedure/animal holding rooms, and a cage rack wash down room. Two of the animal holding rooms will be equipped with 6-70 cage Allentown single sided IVC mouse racks and two with 6-40 cage Allentown single-sided IVC rat racks. The procedure/animal holding room is capable of holding 2 of either kind of rack and will also be able to hold a Biosafety cabinet for animal procedures if needed sometime in the future. These animal rooms will be used to hold breeding animals and animals being held prior to study. Animals will be transferred, housed and used in Levi Hall, which is connected by an underground tunnel to Dunning Hall. The two investigators who will have animals housed in the Dunning Hall facility using the caging purchased with these G20 grant funds have total direct cost Federal funding of almost $ 2.26 million, $ 1.88 million of which comes from the NIH. The addition of this animal holding capability in Dunning Hall will allow the animal holding space in Levi Hall to be used for supporting the research programs of the other investigators on the campus who have $ 5.6 million in grant support from the NIH.