CONTRACEPTION BY BLOCKADE OF PERIOVULATORY EVENTS IN PRIMATES (U54 CENTER)

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 发展研究中心，致力于发现和开发新的避孕药，防止成年雌性灵长类动物在月经周期中发生一种或多种排卵事件。三个研究项目和一个动物核心利用东半球(猕猴)猴子产生新的信息和概念验证，以防止妇女受精，从而防止生育。项目I“控制卵母细胞成熟”将解决这样的假设，即新的卵泡细胞和卵母细胞衍生蛋白控制卵母细胞的核和细胞质成熟，并可被利用来扰乱适时的卵子成熟。此外，该项目还将分析控制卵丘-卵母细胞扩张和卵泡破裂的卵泡/卵丘和卵母细胞来源的蛋白质，并测试拮抗剂是否能阻止排卵和卵子释放。项目III，“配子运输和受精的控制”验证了雌激素作用对正常输卵管和宫颈功能至关重要的假设，即选择性雌激素受体调节剂(SERM)将扰乱配子运输，从而影响受精。在项目I-III中发现的有希望的药物将在非人类灵长类避孕药核心中进行避孕有效性和可逆性测试。与制药业和妇产科的现有联系将促进与为妇女研制新型卵巢/生殖道避孕药具相关的翻译研究。有关进度报告和出版物，请参阅个别项目。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Development Research Center that targets the discovery and development of novel contraceptive drugs that prevent one or more periovulatory events in adult, female primates during the menstrual cycle. Three research projects and one animal core utilize Old World (macaque) monkeys to generate new information and proof-of-concept regarding modalities that prevent oocyte fertilization, and hence fertility, in women. Project I, "Control of Oocyte Maturation", will address the hypothesis that novel follicle cell-, and oocyte-derived proteins control nuclear and cytoplasmic maturation of the oocyte, and can be exploited to disrupt timely egg maturation. Also this project will analyze follicle/cumulus- and oocyte-derived proteins that control cumulus-oocyte expansion and follicle rupture, and test whether antagonists prevent ovulation and egg release. Project III, "Control of Gamete Transport and Fertilization" tests the hypothesis that estrogen action is essential for normal oviductal and cervical function, such that a selective estrogen receptor modulator (SERM) will disrupt gamete transport, and hence, fertilization. Promising agents discovered in Projects I - III will be tested in the Nonhuman Primate Contraceptive Core for contraceptive efficacy and reversibility. Existing ties with the pharmaceutical industry and OB/GYN, OHSU, will promote translational research relevant to formulating novel ovary/reproductive tract-based contraceptives for women. See individual projects for progress reports and publications.