CONTRACEPTION BY BLOCKADE OF PERIOVULATORY EVENTS IN PRIMATES (U54 CENTER)

这个子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 为子项目列出的总成本可能 代表子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 发展研究中心的目标是发现和开发新的避孕药物，防止成年雌性灵长类动物在月经周期中发生一次或多次排卵期事件。 三个研究项目和一个动物核心利用旧世界（猕猴）猴子产生新的信息和概念验证的方式，防止卵母细胞受精，从而生育，在妇女。 项目I，“卵母细胞成熟的控制”，将解决新的卵泡细胞和卵母细胞衍生的蛋白质控制卵母细胞的细胞核和细胞质成熟的假设，并可以被利用来破坏及时的卵子成熟。 此外，该项目将分析卵泡/卵丘和卵母细胞衍生的蛋白质，控制卵丘卵母细胞扩张和卵泡破裂，并测试拮抗剂是否阻止排卵和卵子释放。 项目III，“配子运输和受精的控制”测试雌激素作用对正常输卵管和宫颈功能至关重要的假设，例如选择性雌激素受体调节剂（SERM）将破坏配子运输，从而破坏受精。 在项目I-III中发现的有希望的药物将在非人灵长类避孕药核心中进行避孕效力和可逆性测试。 与制药业和OB/GYN，OHSU的现有联系将促进与制定新型卵巢/生殖道避孕药相关的转化研究。请参阅各个项目的进度报告和出版物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Development Research Center that targets the discovery and development of novel contraceptive drugs that prevent one or more periovulatory events in adult, female primates during the menstrual cycle. Three research projects and one animal core utilize Old World (macaque) monkeys to generate new information and proof-of-concept regarding modalities that prevent oocyte fertilization, and hence fertility, in women. Project I, "Control of Oocyte Maturation", will address the hypothesis that novel follicle cell-, and oocyte-derived proteins control nuclear and cytoplasmic maturation of the oocyte, and can be exploited to disrupt timely egg maturation. Also this project will analyze follicle/cumulus- and oocyte-derived proteins that control cumulus-oocyte expansion and follicle rupture, and test whether antagonists prevent ovulation and egg release. Project III, "Control of Gamete Transport and Fertilization" tests the hypothesis that estrogen action is essential for normal oviductal and cervical function, such that a selective estrogen receptor modulator (SERM) will disrupt gamete transport, and hence, fertilization. Promising agents discovered in Projects I - III will be tested in the Nonhuman Primate Contraceptive Core for contraceptive efficacy and reversibility. Existing ties with the pharmaceutical industry and OB/GYN, OHSU, will promote translational research relevant to formulating novel ovary/reproductive tract-based contraceptives for women. See individual projects for progress reports and publications.