COOPERATIVE RESEARCH ON INFERTILITY IN PRIMATES (U54)

灵长类动物不育症的合作研究 (U54)

• 批准号: 8357738
• 负责人: RICHARD L STOUFFER
• 金额: $ 7.28万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357738
• 关键词: Address; Androgens; Angiopoietins; Assisted Reproductive Technology; Chronic; Clinical; Diet; Disease; Drug Formulations; Endocrine Glands; Etiology; Female; Fertility; Funding; Genes; Genetic; Germ Cells; Grant; Human; Image; Individual; Infertility; Laboratories; Lesion; Macaca mulatta; Molecular and Cellular Biology; Monkeys; Morphology; National Center for Research Resources; Neurons; Neurosecretory Systems; Ovarian; Ovarian Diseases; Ovarian Hyperstimulation Syndrome; Ovarian Stimulations; Pathway interactions; Periodicity; Primates; Principal Investigator; Progress Reports; Publications; Reproduction; Reproductive Process; Research; Research Infrastructure; Research Project Grants; Resources; Role; Source; Stress; Syndrome; Testosterone; Translational Research; United States National Institutes of Health; Vascular Endothelial Growth Factors; Women' s Health; corpus luteum; cost; gamma-Aminobutyric Acid; nonhuman primate; novel; prepuberty; psychosocial; relating to nervous system; reproductive

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ONPRC's Specialized Cooperative Center (U54) in Infertility and Reproduction Research addresses the causes and cures of human infertility disorders as they pertain to neural, gonadal and gamete deficits. Each research project utilizes nonhuman primates in translational research, and two contain clinical components that relate new information to women's health. Project I, "Effect of Common Stresses on Fertility" investigates the neuroendocrine and gonadal lesions associated with a combination of mild forms of stress (e.g., dieting, psychosocial changes). Project II, "Novel Mechanisms Underlying the Transsynaptic Control of LHRH Release" continues genetic and cellular manipulations to evaluate the role of GABA input, and other novel genes (e.g., IAP-1) in neuronal pathways, in controlling LHRH neurons and reproductive cyclicity. Project III, "Angiogenic and Angiolytic Factors in Natural and Controlled Ovarian Stimulation (COS) Cycles" examines the expression and action of angiopoietin (Ang) and endocrine gland (EG)-VEGF in the follicle and corpus luteum, and whether alterations in Ang, EG-VEGF, as well as VEGF-A, cause ovarian disorders, such as ovarian hyperstimulation syndrome (OHSS). Project IV, "Androgen Exposure in Female Pre-pubertal Monkeys: Relevance to PCOS?", will determine whether chronic exposure of prepubertal female rhesus monkeys to elevated levels of testosterone causes changes in the neuroendocrine-ovarian axis reminiscent of those observed in polycystic ovarian syndrome (PCOS). All projects attempt to relate basic reproductive processes to the etiology and/or treatment of infertility. These projects are supported by three core (Assisted Reproductive Technologies; Imaging & Morphology; Molecular & Cellular Biology) laboratories operating in an "open access" formulation. See individual projects for progress reports and publications.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 ONPRC的不育和生殖研究专业合作中心（U 54）致力于人类不育症的原因和治疗，因为它们涉及神经，性腺和配子缺陷。 每个研究项目都利用非人类灵长类动物进行转化研究，其中两个项目包含将新信息与妇女健康联系起来的临床组成部分。项目I，“常见压力对生育力的影响”研究了与轻度压力（例如，节食、心理社会变化）。 项目II，“LHRH释放的跨突触控制的新机制”继续进行遗传和细胞操作，以评估GABA输入和其他新基因（例如，IAP-1）在神经元通路中，在控制LHRH神经元和生殖周期中。 项目III，“自然和控制性卵巢刺激（COS）周期中的血管生成和血管溶解因子”检查卵泡和黄体中血管生成素（Ang）和内分泌腺（EG）-VEGF的表达和作用，以及Ang，EG-VEGF和VEGF-A的改变是否会导致卵巢疾病，如卵巢过度刺激综合征（OHSS）。 项目四，“雄激素暴露在女性青春期前的猴子：与PCOS？“，将确定青春期前雌性恒河猴长期暴露于高水平的睾酮是否会引起神经内分泌-卵巢轴的变化，使人想起在多囊卵巢综合征（PCOS）中观察到的变化。所有项目都试图将基本生殖过程与不孕症的病因和/或治疗联系起来。 这些项目由三个核心实验室（辅助生殖技术;成像和形态学;分子和细胞生物学）支持，这些实验室以“开放获取”的方式运作。请参阅各个项目的进度报告和出版物。