COOPERATIVE RESEARCH ON INFERTILITY IN PRIMATES (U54)

灵长类动物不育症的合作研究 (U54)

• 批准号: 8357738
• 负责人: RICHARD L STOUFFER
• 金额: $ 7.28万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357738
• 关键词: Address; Androgens; Angiopoietins; Assisted Reproductive Technology; Chronic; Clinical; Diet; Disease; Drug Formulations; Endocrine Glands; Etiology; Female; Fertility; Funding; Genes; Genetic; Germ Cells; Grant; Human; Image; Individual; Infertility; Laboratories; Lesion; Macaca mulatta; Molecular and Cellular Biology; Monkeys; Morphology; National Center for Research Resources; Neurons; Neurosecretory Systems; Ovarian; Ovarian Diseases; Ovarian Hyperstimulation Syndrome; Ovarian Stimulations; Pathway interactions; Periodicity; Primates; Principal Investigator; Progress Reports; Publications; Reproduction; Reproductive Process; Research; Research Infrastructure; Research Project Grants; Resources; Role; Source; Stress; Syndrome; Testosterone; Translational Research; United States National Institutes of Health; Vascular Endothelial Growth Factors; Women' s Health; corpus luteum; cost; gamma-Aminobutyric Acid; nonhuman primate; novel; prepuberty; psychosocial; relating to nervous system; reproductive

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ONPRC's Specialized Cooperative Center (U54) in Infertility and Reproduction Research addresses the causes and cures of human infertility disorders as they pertain to neural, gonadal and gamete deficits. Each research project utilizes nonhuman primates in translational research, and two contain clinical components that relate new information to women's health. Project I, "Effect of Common Stresses on Fertility" investigates the neuroendocrine and gonadal lesions associated with a combination of mild forms of stress (e.g., dieting, psychosocial changes). Project II, "Novel Mechanisms Underlying the Transsynaptic Control of LHRH Release" continues genetic and cellular manipulations to evaluate the role of GABA input, and other novel genes (e.g., IAP-1) in neuronal pathways, in controlling LHRH neurons and reproductive cyclicity. Project III, "Angiogenic and Angiolytic Factors in Natural and Controlled Ovarian Stimulation (COS) Cycles" examines the expression and action of angiopoietin (Ang) and endocrine gland (EG)-VEGF in the follicle and corpus luteum, and whether alterations in Ang, EG-VEGF, as well as VEGF-A, cause ovarian disorders, such as ovarian hyperstimulation syndrome (OHSS). Project IV, "Androgen Exposure in Female Pre-pubertal Monkeys: Relevance to PCOS?", will determine whether chronic exposure of prepubertal female rhesus monkeys to elevated levels of testosterone causes changes in the neuroendocrine-ovarian axis reminiscent of those observed in polycystic ovarian syndrome (PCOS). All projects attempt to relate basic reproductive processes to the etiology and/or treatment of infertility. These projects are supported by three core (Assisted Reproductive Technologies; Imaging & Morphology; Molecular & Cellular Biology) laboratories operating in an "open access" formulation. See individual projects for progress reports and publications.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 ONPRC在不育和繁殖研究方面的专业合作中心（U54）涉及与神经，性腺和配子缺陷有关的人类不孕症障碍的原因和治疗方法。 每个研究项目都在转化研究中使用非人类灵长类动物，并且两个包含将新信息与妇女健康相关的临床组成部分。项目I，“普通压力对生育能力的影响”研究了与轻度压力形式（例如，节食，社会心理变化）相关的神经内分泌和性腺病变。 项目II，“ LHRH释放的透射性控制的基础的新型机制”继续遗传和细胞操作，以评估GABA输入的作用，以及其他新型基因（例如IAP-1）在神经元途径中，在控制LHRH Neurons和繁殖环境中。 项目III，“自然和受控卵巢刺激（COS）周期中的血管生成和血管性因素”研究了牛the虫（ANG）和内分泌腺体（EG）-VEGF在卵泡和紫胶中的表达和作用（OHSS）。 IV项目，“雌性前鸟前猴子的雄激素暴露：与PCOS相关？”，是否会确定在慢性雌性恒河猴中是否会暴露于睾丸激素水平升高的睾丸激素水平是否会导致神经内分泌 - 伏诺氏群的变化导致神经内分泌 - 卵巢症的变化。所有项目都试图将基本生殖过程与不孕症的病因和/或治疗联系起来。 这些项目得到了三个核心（辅助生殖技术；成像和形态；分子和细胞生物学）实验室，以“开放访问”配方运行。有关进度报告和出版物的各个项目。