Hyperandrogenemia, Diet and Female Reproductive Health

高雄激素血症、饮食和女性生殖健康

• 批准号: 8642536
• 负责人: RICHARD L STOUFFER
• 金额: $ 179.32万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8642536
• 关键词: Address; Adipose tissue; Androgens; Awareness; California; Clinical; Collaborations; Diet; Etiology; Fatty acid glycerol esters; Female; Fertility; Fertility Disorders; Fructose; Functional disorder; Health Sciences; Human; Hypothalamic structure; Infertility; Lead; Los Angeles; Macaca mulatta; Metabolic; Modeling; Neurosecretory Systems; Obesity; Oregon; Ovarian; Ovary; Pituitary Gland; Population; Prevalence; Primates; Reproduction; Reproductive Health; Research; Research Project Grants; Resources; Role; Structure; Syndrome; Testosterone; Universities; Woman; design; improved; insight; nonhuman primate; outreach; programs; public health relevance; reproductive; response; treatment effect

DESCRIPTION (provided by applicant): The Oregon National Primate Research Center (ONPRC) at the Oregon Health & Science University (OHSU) proposes a Specialized Cooperative Center in Reproduction and Infertility Research (U54) that addresses the effects of hyperandrogenemia and obesity on female reproductive health. An interdisciplinary, translational program is designed to discern between the effects of excess androgen exposure and metabolic changes due to a typical Western-style diet (WSD, high fat and fructose content) on: (1) the hypothalamus-pituitary-ovary-reproductive tract axis, as well as adipose tissue; (2) the impact on fertility; and (3) if the treatment effects are reversible. Three research projects ue the nonhuman primate model, and one project focuses on the specific population of lean women with polycystic ovarian syndrome (PCOS). Project I, "Metabolic and Neuroendocrine Responses to Hyperandrogenemia and Diet", is directed by J. Cameron, via a consortium with the University of Pittsburgh and K. Grove at ONPRC. Project II, "Ovarian and Uterine Structure-Function: Influence of Androgen and Diet", is a collaboration between R. Stouffer and O. Slayden, ONPRC. Project III, "Effects of Androgen and Diet on Adipose Function," involves C. Roberts and colleagues at ONPRC. Project IV, "Androgen Excess as a Mechanism for Adipogenic Dysfunction in PCOS Women," incorporates a consortium with clinical experts (D. Dumesic, G. Chazenbalk) at the University of California, Los Angeles. Projects l-lll will be supported by a nonhuman primate (NHP) Core (O. Slayden, Supervisor) operating as a closed resource. This Core will maintain four treatment groups of young, female rhesus monkeys (controls, testosterone or T-treated, WSD-treated, and T + WSD) for four years, culminating in a fertility trial. In Year 05, reversibility of T and WSD actions will be examined. In addition, the Administrative Core (R. Stouffer, P.I.), and Outreach Core (D. Gordon and M. Zelinski) will promote interactions within and among SCCPIR Centers and increase public awareness and understanding of reproductive health research. Important, new information will accrue on the actions of androgen and diet-related factors, individually and in combination, relevant to the etiology and treatment of fertility disorders, such as PCOS.

描述（由申请人提供）：俄勒冈健康与科学大学 (OHSU) 的俄勒冈国家灵长类动物研究中心 (ONPRC) 提议设立生殖和不孕研究专业合作中心 (U54)，以解决高雄激素血症和肥胖对女性生殖健康的影响。一项跨学科的转化计划旨在辨别典型西式饮食（WSD、高脂肪和果糖含量）导致的过量雄激素暴露和代谢变化对以下方面的影响：（1）下丘脑-垂体-卵巢-生殖道轴以及脂肪组织； (2)对生育的影响； (3)治疗效果是否可逆。三个研究项目采用非人类灵长类动物模型，其中一个项目侧重于患有多囊卵巢综合征 (PCOS) 的瘦女性特定人群。 项目 I“对高雄激素血症和饮食的代谢和神经内分泌反应”由 J. Cameron 与匹兹堡大学和 ONPRC 的 K. Grove 联合领导。项目 II“卵巢和子宫结构功能：雄激素和饮食的影响”是 R. Stouffer 和 O. Slayden，ONPRC。项目 III“雄激素和饮食对脂肪功能的影响”由 C. Roberts 和 ONPRC 的同事参与。项目 IV“雄激素过多是 PCOS 女性脂肪生成功能障碍的机制”，由加州大学洛杉矶分校的临床专家（D. Dumesic、G. Chazenbalk）组成的联盟组成。项目 l-lll 将得到作为封闭资源运行的非人类灵长类 (NHP) 核心（O. Slayden，主管）的支持。该核心将维持四个年轻雌性恒河猴治疗组（对照组、睾酮或 T 治疗组、WSD 治疗组和 T + WSD 治疗组）四年，最终进行生育试验。在第 05 年，将检查 T 和 WSD 操作的可逆性。此外，行政核心（R. Stouffer，P.I.）和外展核心（D. Gordon 和 M. Zelinski）将促进 SCCPIR 中心内部和之间的互动，并提高公众对生殖健康研究的认识和理解。重要的是，关于雄激素和饮食相关因素的作用的新信息，无论是单独的还是组合的，都与生育障碍（如多囊卵巢综合症）的病因和治疗相关。