Hyperandrogenemia, Diet and Female Reproductive Health

高雄激素血症、饮食和女性生殖健康

• 批准号: 9039467
• 负责人: RICHARD L STOUFFER
• 金额: $ 193.94万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9039467
• 关键词: Address; Adipose tissue; Androgens; Awareness; California; Clinical; Collaborations; Diet; Etiology; Fatty acid glycerol esters; Female; Fertility; Fertility Disorders; Fructose; Functional disorder; Health Sciences; Human; Hypothalamic structure; Infertility; Lead; Los Angeles; Macaca mulatta; Metabolic; Modeling; Neurosecretory Systems; Obesity; Oregon; Ovarian; Ovary; Pituitary Gland; Population; Prevalence; Primates; Reproduction; Reproductive Health; Research; Research Project Grants; Resources; Role; Structure; Syndrome; Testosterone; Universities; Woman; design; improved; insight; nonhuman primate; outreach; programs; public health relevance; reproductive; reproductive tract; response; treatment effect; treatment group

DESCRIPTION (provided by applicant): The Oregon National Primate Research Center (ONPRC) at the Oregon Health & Science University (OHSU) proposes a Specialized Cooperative Center in Reproduction and Infertility Research (U54) that addresses the effects of hyperandrogenemia and obesity on female reproductive health. An interdisciplinary, translational program is designed to discern between the effects of excess androgen exposure and metabolic changes due to a typical Western-style diet (WSD, high fat and fructose content) on: (1) the hypothalamus-pituitary-ovary-reproductive tract axis, as well as adipose tissue; (2) the impact on fertility; and (3) if the treatment effects are reversible. Three research projects ue the nonhuman primate model, and one project focuses on the specific population of lean women with polycystic ovarian syndrome (PCOS). Project I, "Metabolic and Neuroendocrine Responses to Hyperandrogenemia and Diet", is directed by J. Cameron, via a consortium with the University of Pittsburgh and K. Grove at ONPRC. Project II, "Ovarian and Uterine Structure-Function: Influence of Androgen and Diet", is a collaboration between R. Stouffer and O. Slayden, ONPRC. Project III, "Effects of Androgen and Diet on Adipose Function," involves C. Roberts and colleagues at ONPRC. Project IV, "Androgen Excess as a Mechanism for Adipogenic Dysfunction in PCOS Women," incorporates a consortium with clinical experts (D. Dumesic, G. Chazenbalk) at the University of California, Los Angeles. Projects l-lll will be supported by a nonhuman primate (NHP) Core (O. Slayden, Supervisor) operating as a closed resource. This Core will maintain four treatment groups of young, female rhesus monkeys (controls, testosterone or T-treated, WSD-treated, and T + WSD) for four years, culminating in a fertility trial. In Year 05, reversibility of T and WSD actions will be examined. In addition, the Administrative Core (R. Stouffer, P.I.), and Outreach Core (D. Gordon and M. Zelinski) will promote interactions within and among SCCPIR Centers and increase public awareness and understanding of reproductive health research. Important, new information will accrue on the actions of androgen and diet-related factors, individually and in combination, relevant to the etiology and treatment of fertility disorders, such as PCOS.

描述（由申请人提供）：俄勒冈健康与科学大学（OHSU）的俄勒冈国家灵长类动物研究中心（ONPRC）提出了一个生殖和不孕症研究专业合作中心（U54），以解决高雄激素血症和肥胖对女性生殖健康的影响。一个跨学科的转化项目旨在辨别过量雄激素暴露和典型西式饮食（WSD，高脂肪和果糖含量）对代谢变化的影响：(1)下丘脑-垂体-卵巢-生殖道轴以及脂肪组织；(2)对生育的影响；(3)治疗效果是否可逆。三个研究项目使用非人灵长类动物模型，一个项目重点研究患有多囊卵巢综合征（PCOS）的瘦弱女性的特定人群。项目一，“代谢和神经内分泌对高雄激素血症和饮食的反应”，由J. Cameron主持，由匹兹堡大学和ONPRC的K. Grove联合主持。项目二，“卵巢和子宫结构-功能：雄激素和饮食的影响”，是R. Stouffer和