ALCOHOL AND TB IN NONHUMAN PRIMATES

非人类灵长类动物中的酒精和结核病

• 批准号: 8358137
• 负责人: Carol A. Mason
• 金额: $ 2.9万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358137
• 关键词: Aerosols; Alcohols; Disease; Funding; Grant; Macaca mulatta; Mycobacterium tuberculosis; National Center for Research Resources; Primates; Principal Investigator; Protocols documentation; Relative (related person); Research; Research Infrastructure; Resources; Route; Source; Testing; United States National Institutes of Health; binge drinking; cost; latent infection; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We will test the hypothesis that binge alcohol consumption will cause the reactivation of latent TB disease in primates. Towards this end, we will use previously developed protocol to generate binge alcohol consumption in rhesus macaques and infect them with latent Mtb via the aerosol route. We will ask if latent infection reactivates, relative to historic controls, which received a similar amount of the same Mtb strain.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们将检验这一假设，即酗酒会导致灵长类动物潜伏性结核病的重新激活。为此，我们将使用先前开发的方案在恒河猴中产生酗酒，并通过气溶胶途径用潜伏的Mtb感染它们。我们将询问相对于接受类似量的相同Mtb菌株的历史对照，潜伏感染是否重新激活。