ALCOHOL AND TB IN NONHUMAN PRIMATES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 我们将测试这一假设，即酗酒会导致灵长类动物中潜伏的结核病重新激活。为此，我们将使用以前开发的方案来产生恒河猴的酗酒行为，并通过气雾剂途径将潜伏的结核分枝杆菌感染它们。我们会问，相对于接受相同数量相同结核分枝杆菌菌株的历史对照，潜伏感染是否会重新激活。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We will test the hypothesis that binge alcohol consumption will cause the reactivation of latent TB disease in primates. Towards this end, we will use previously developed protocol to generate binge alcohol consumption in rhesus macaques and infect them with latent Mtb via the aerosol route. We will ask if latent infection reactivates, relative to historic controls, which received a similar amount of the same Mtb strain.