ALCOHOL AND TB IN NONHUMAN PRIMATES

这个子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 表示子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 我们将检验这一假设，即酗酒会导致灵长类动物潜伏性结核病的重新激活。为此，我们将使用先前开发的方案在恒河猴中产生酗酒，并通过气溶胶途径用潜伏的Mtb感染它们。我们将询问相对于接受类似量的相同Mtb菌株的历史对照，潜伏感染是否重新激活。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We will test the hypothesis that binge alcohol consumption will cause the reactivation of latent TB disease in primates. Towards this end, we will use previously developed protocol to generate binge alcohol consumption in rhesus macaques and infect them with latent Mtb via the aerosol route. We will ask if latent infection reactivates, relative to historic controls, which received a similar amount of the same Mtb strain.