PSM Moffitt Cancer Center Partnership

PSM 莫菲特癌症中心合作伙伴

• 批准号: 8326250
• 负责人: Jose A Torres-Ruiz
• 金额: $ 15万
• 依托单位: PONCE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-20 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8326250
• 关键词: Area; Basic Science; Cancer Center; Cancer Control; Cancer Patient; Cancer Research Infrastructure; Cancer Research Project; Caring; Catchment Area; Cities; Clinical; Clinical Research; Clinical Trials; Colitis; Collaborations; Community Medicine; Comprehensive Cancer Center; Cutaneous; Development; Diagnostic; Discipline; Doctor of Medicine; Doctor of Philosophy; Doctor' s Degree; Dysplasia; Enrollment; Epidemic; Epidermal Growth Factor Receptor; Faculty; Family Practice; Florida; Funding; Generations; Goals; Grant; Health; Hispanics; Hospitals; Human papilloma virus infection; Improve Access; Incidence; Individuality; Institution; Knowledge; Lead; Malignant Neoplasms; Master of Public Health; Medical Education; Medical Students; Minority; Outcome; Patients; Population; Prevention education; Primary Health Care; Psychology; Puerto Rican; Puerto Rico; Recruitment Activity; Research; Research Personnel; Research Project Grants; Science; Scientist; Screening procedure; Skin Carcinoma; Social Marketing; Staging; Students; Sushi Domain; TACR1 gene; Technology; Therapeutic; Therapy Clinical Trials; Tissue Banking; Tissue Banks; Tissue Procurements; Training; Training Programs; Work; anticancer research; cancer care; cancer education; cancer prevention; cancer therapy; career; cost; design; improved; interest; medical schools; meetings; oncology; operation; outreach; outreach program; programs; racial and ethnic; treatment center

The geographic proximity and large Hispanic populations in Florida and Puerto Rico have driven a longstanding effort by the Ponce School of Medicine and the Moffitt Cancer Center to develop an academic partnership. The complementary expertise at both institutions provides a synergistic means of studying the cancer problem in Puerto Ricans, and in the Hispanic population in general. Interactions between the PSM and the MCC have been ongoing for the past 4 years, and effective working relationships between theleadership and investigators from both institutions have been formed, and collaborations have begun. An implementation plan has been devised focusing on four target areas: (1) basic research, (2) cancer education and training, (3) outreach, and (4) tissue procurement. Basic scientists from both institutions with shared interests and complementary expertise have jointly developed 2 basic research projects: (1) "Cutaneous human papillomavirus infection and non-melanoma skin cancer in the U.S. and Puerto Rico," and (2) "Targeting SP-NK1R-EGFR interactions in colitis associated dysplasia" In addition to synergistic hypothesis generation the partnership permits the sharing of technology available at the MCC and not at the PSM, and allows the PSM to develop cancer research programs, utilizing the expertise of MCC faculty. It is also a high priority of the PSM to develop the capacity to conduct investigator-initiated clinical research involving cancer patients, and to recruit new cancer faculty through the RCMI Program to accomplish this. Although the PSM has considerable expertise in other clinical disciplines, oncology needs to be developed in order to serve as a tertiary referral center for cancer care in southwest Puerto Rico. The cancer education and training program is designed to accomplish this in staged fashion. Plans for the training of medical students, residents, and faculty in cancer care and clinical research have been devised. The outreach program will eventually encompass a variety of different cancer prevention activities. Initially, a social marketing strategy will be used to determine the needs in Puerto Rico. The Tissue Procurement Core will support the research projects by banking tissue from cancer patients and normal controls in Puerto Rico. The reciprocal benefits for the MCC are the training of medical students, oncology fellows, and faculty in issues specific to the cancer problem in Puerto Rico that will provide an enhanced ability to appropriately treat Hispanic cancer patients in Florida, more effectively involve them in clinical research, and produce more effective cancer control programs for Hispanic communities in Florida. A partnership between the PSM and the MCC will likely lead to improved outcomes for Hispanic cancer patients in Puerto Rico and Florida who are currently underserved with respect to cancer care and participation in clinical research.

佛罗里达州和波多黎各的地理邻近性和大量西班牙裔人口推动了长期的 庞塞医学院和莫菲特癌症中心努力建立学术伙伴关系。两个机构的互补专业知识为研究波多黎各人和整个西班牙裔人口的癌症问题提供了一种协同手段。过去四年来，PSM 和 MCC 之间的互动一直在持续，双方领导层和调查人员之间已经形成了有效的工作关系，并开始了合作。已制定实施计划，重点关注四个目标领域：(1) 基础研究、(2) 癌症教育和培训、(3) 推广和 (4) 组织采购。两个机构的基础科学家有着共同的兴趣和互补的专业知识，共同开发了两个基础研究项目：（1）“美国和波多黎各的皮肤人乳头瘤病毒感染和非黑色素瘤皮肤癌”， (2)“针对结肠炎相关发育不良中的 SP-NK1R-EGFR 相互作用”除了产生协同假设之外，该合作伙伴关系还允许共享 MCC 而不是 PSM 可用的技术，并允许 PSM 利用 MCC 教员的专业知识开发癌症研究项目。 PSM 的一个高度优先事项是培养开展由研究者发起的涉及癌症患者的临床研究的能力，并通过 RCMI 计划招募新的癌症教师来实现这一目标。尽管 PSM 在其他临床学科方面拥有相当多的专业知识，但肿瘤学仍需发展，才能成为波多黎各西南部癌症护理的三级转诊中心。癌症教育和培训计划旨在以分阶段的方式实现这一目标。已经制定了对医学生、住院医生和教职人员进行癌症护理和临床研究培训的计划。 外展计划最终将涵盖各种不同的癌症预防活动。最初，将使用社会营销策略来确定波多黎各的需求。组织采购核心将通过储存波多黎各癌症患者和正常对照的组织来支持研究项目。 MCC 的互惠利益是对波多黎各癌症问题的医学生、肿瘤学研究员和教师进行培训，这将增强适当治疗佛罗里达州西班牙裔癌症患者的能力，更有效地让他们参与临床研究，并为佛罗里达州西班牙裔社区制定更有效的癌症控制计划。 PSM 和 MCC 之间的合作可能会改善波多黎各和佛罗里达州西班牙裔癌症患者的治疗结果，这些患者目前在癌症护理和参与临床研究方面服务不足。

项目成果

The Establishment of the First Cancer Tissue Biobank at a Hispanic-Serving Institution: A National Cancer Institute-Funded Initiative between Moffitt Cancer Center in Florida and the Ponce School of Medicine and Health Sciences in Puerto Rico.

在西班牙裔服务机构建立第一个癌症组织生物库：佛罗里达州莫菲特癌症中心和波多黎各庞塞医学与健康科学学院之间由国家癌症研究所资助的一项计划。

• DOI: 10.1089/bio.2011.0028
• 发表时间: 2011
• 期刊: Biopreservation and biobanking
• 影响因子: 1.6
• 作者: Flores,Idhaliz;Muñoz-Antonia,Teresita;Matta,Jaime;García,Miosotis;Fenstermacher,David;Gutierrez,Sylvia;Seijo,Edward;Torres-Ruiz,Jose';Pledger,WJack;Coppola,Domenico
• 通讯作者: Coppola,Domenico

Effect of hydroxychloroquine and characterization of autophagy in a mouse model of endometriosis.

• DOI: 10.1038/cddis.2015.361
• 发表时间: 2016-01-14
• 期刊: Cell death & disease
• 影响因子: 9
• 作者: Ruiz A;Rockfield S;Taran N;Haller E;Engelman RW;Flores I;Panina-Bordignon P;Nanjundan M
• 通讯作者: Nanjundan M