The Norwegian Mother And Child Study: Environmental Specimen Collection

挪威母子研究：环境样本收集

• 批准号: 8336544
• 负责人: Matthew Longnecker
• 金额: $ 74.15万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8336544
• 关键词: Autistic Disorder; Biological; Birth; Blood; Chemistry; Child; Cohort Studies; Collection; Data; Data Collection; Development; Dietary intake; Disease; Enrollment; Environmental Exposure; Exposure to; Fathers; Finding by Cause; Future; Genes; Gestational Diabetes; Health; Human; Infant; Journals; Manuscripts; Measures; Medical; Metabolic; Metabolic syndrome; Morphologic artifacts; Mothers; National Institute of Environmental Health Sciences; Organophosphates; Outcome; Paper; Perinatal Exposure; Pesticides; Phase; Physical activity; Predisposition; Pregnancy; Protocols documentation; Publishing; Questionnaires; Reporting; Reproducibility; Research Design; Research Personnel; Risk; Risk Factors; Scientist; Series; Serum; Specimen; Spontaneous abortion; System; Testing; Time; Tobacco smoke; Trace Elements; Urine; Whole Blood; Woman; Writing; base; bisphenol A; cleft lip and palate; cohort; disorder risk; fetal; in utero; neurodevelopment; pesticide exposure; sample collection; stillbirth; transmission process

The Norwegian Mother and Child Cohort Study (MoBa) is an ongoing prebirth cohort study. Enrollment was completed in 2008 resulting in 106,980 pregnancies in the study. The study is based on questionnaires completed by the mother and father, and biological specimens are collected from the mother, father and child. The main purpose of the study is to find causes of diseases. NIEHS is providing partial support for the study, and in 2002 expanded the data collection protocol to include collection of more biologic specimens from the mothers during the 17th week of pregnancy (additional serum, a specimen of whole blood collected in a trace-element free container, and urine). These specimens will enhance the ability to examine the relation of environmental exposures in relation to various health outcomes in the children and their mothers. As of April 30, 2009, 77,104 subjects had provided blood and urine that was collected in conjunction with NIEHS. In the past year, using the MoBa data, we have conducted a series of studies of health effects of in utero exposure to tobacco smoke. One report, on the association with miscarriage and stillbirth was published; no association was found. A second report, on the reproducibility of reported in utero exposure to tobacco smoke, was also published; the results show the reports of exposure are highly reproducible. We are now examining in utero exposure to tobacco smoke in relation to components of the metabolic syndrome and find evidence of an association. One manuscript reporting this finding has been revised and resubmitted to a journal, and a second manusecript is ready to be submitted after the first one is accepted. We added to the MoBa protocol the collection additional urine specimens in pregnancy, at weeks 23 and 29, for a subset of women. 690 women have a complete set of three urine specimens from pregnancy. We wrote a protocol to measure the levels of metabolites of organophosphate pesticides and bisphenol A in these specimens, to determine how reproducibile the levels are; the specimens are now being analyzed. This information will help us plan future studies on associations with health outcomes. We also have been studying perfluorinated alklys in relation to time-to-pregnancy and birthweight among women in the MoBa cohort. The association with increased time-to-pregnancy reported by others was also present in the MoBa data but appears to be due to an artifact of the study design; our manuscript on this has been revised and resubmitted to a journal. A manuscript on the association of perfluorinated compounds with birthweight also received favorable reviews from a journal and is being revised. We plan at least two other papers based on these data; one on values of clincial chemistry paramters in relation to perfluorinated compound levels, and one on determinants of blood levels. Because the study is in a relatively early phase, the number of scientific reports is still limited. At NIEHS, we are developing several studies that will be nested within MoBa. A list of the studies currently planed includes: Risk Factors for Cleft Lip and Palate, A Search for the Non-mendelian Transmission of Human Genes, Mother's Physical Activity During Pregnancy and Fetal Loss, Dietary Intake and Gestational Diabetes, Physical Activity in Pregnancy and Infant Neurodevelopment, Organophosphate Pesticide Exposure and Risk of Autism, and additional studies on perfluorinated compound exposure and health.

挪威母亲和儿童队列研究（MoBa）是一项正在进行的出生前队列研究。 入组于2008年完成，研究中有106，980例妊娠。这项研究是基于母亲和父亲完成的问卷调查，并从母亲，父亲和孩子身上收集生物标本。这项研究的主要目的是找出疾病的原因。 NIEHS为这项研究提供了部分支持，并在2002年扩大了数据收集方案，包括在怀孕第17周期间从母亲那里收集更多的生物标本（额外的血清，在无微量元素容器中收集的全血标本和尿液）。 这些样本将提高研究环境暴露与儿童及其母亲各种健康结果之间关系的能力。 截至2009年4月30日，已有77，104名受试者提供了与NIEHS联合收集的血液和尿液。 在过去的一年里，利用MoBa数据，我们对子宫内暴露于烟草烟雾的健康影响进行了一系列研究。 一份关于流产和死产的报告发表了，没有发现相关性;另一份关于子宫内暴露于烟草烟雾的报告的可重复性也发表了，结果显示暴露报告的可重复性很高。 我们现在正在研究子宫内暴露于烟草烟雾与代谢综合征成分的关系，并找到相关的证据。 一份报告这一发现的手稿已经被修改并重新提交给期刊，第二份手稿在第一份被接受后准备提交。 我们在MoBa方案中增加了一部分女性在妊娠第23周和第29周采集额外尿液标本的内容。 690名妇女有一套完整的三个尿液标本从怀孕。 我们写了一份协议来测量这些标本中有机磷农药和双酚A的代谢物水平，以确定这些水平的可重复性;这些标本现在正在分析中。 这些信息将有助于我们计划未来的研究与健康结果的关联。 我们还一直在研究全氟烷基与MoBa队列中女性怀孕时间和出生体重的关系。 其他人报告的与妊娠时间增加的相关性也存在于MoBa数据中，但似乎是由于研究设计的人为因素造成的;我们对此的手稿进行了修订并重新提交给期刊。 一篇关于全氟化合物与出生体重之间关系的论文也得到了一份期刊的好评，目前正在修订中。 我们计划在这些数据的基础上，至少有两个其他文件，一个临床化学参数的值与全氟化合物的水平，和血液水平的决定因素之一。 由于这项研究处于相对早期的阶段，科学报告的数量仍然有限。 在NIEHS，我们正在开发几项将嵌入MoBa的研究。 目前计划开展的研究包括：唇腭裂的风险因素、人类基因的非孟德尔传播研究、母亲在怀孕期间的身体活动和胎儿丢失、饮食摄入和妊娠糖尿病、怀孕期间的身体活动和婴儿神经发育、有机磷农药接触和自闭症风险，以及关于全氟化合物接触和健康的其他研究。