Effect Of Diet and Other Early Exposures on Child Health and Development

饮食和其他早期暴露可能会影响儿童发育和几种慢性疾病的风险，但需要进行更多的研究。 在这个包罗万象的项目中描述的当前研究包括一个项目，如下所述。 我们研究了妊娠期糖尿病与在围产期合作项目中出生的后代随后发生尿道下裂和隐睾的风险之间的关系。 未发现相关性，这可能是因为妊娠期糖尿病导致的代谢紊乱发生在胎儿发育期之后，此时胎儿最容易受到环境影响。发表了一份报告。 我们研究了妊娠期母体药物激素使用与儿童期肥胖的关系。 在怀孕的特定时期服用己烯雌酚或口服避孕药的孕妇更有可能生下肥胖的孩子。 这些发现为“致肥原”假说提供了普遍支持。 一份报告正在印刷中。

Diet and other early exposures may affect child development and the risk of several chronic diseases, but additional research is needed. The current research described in this catch-all project comprises one project, described below. We examined the association of gestational diabetes with subsequent risk of hypospadias and cryptorchidism in offspring born in the Collaborative Perinatal Project. No association was found, which may be because the metabolic disturbances due to gestational diabetes occur after the period of fetal development when the fetus is most susceptible to environmental influences. A report was published. We examined in utero exposure to maternal pharmacologic hormone use in pregnancy in relation to obesity in childhood. Pregnant women who took diethylstilbestrol or oral contraceptives during specific periods of pregnancy were more likely to have obese children. The findings provide general support for the "obesogens" hypothesis. A report is in press.