Effect Of Diet and Other Early Exposures on Child Health and Development

饮食和其他早期暴露对儿童健康和发育的影响

• 批准号: 8929729
• 负责人: Matthew Longnecker
• 金额: $ 7.61万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8929729
• 关键词: Affect; Annual Reports; Area; Child Development; Child health care; Childhood; Chronic Disease; Cryptorchidism; Diet; Diethylstilbestrol; Exposure to; Fetal Development; Fetus; Gestational Diabetes; Hormones; Hypospadias; Metabolic; Obesity; Oral Contraceptives; Perinatal; Perinatal Exposure; Pregnancy; Pregnant Women; Publishing; Reporting; Research; Risk; Work; obesity in children; obesogen; offspring

Diet and other early exposures may affect child development and the risk of several chronic diseases, but additional research is needed. The current research described in this catch-all project comprises one project, described below. We examined the association of gestational diabetes with subsequent risk of hypospadias and cryptorchidism in offspring born in the Collaborative Perinatal Project. No association was found, which may be because the metabolic disturbances due to gestational diabetes occur after the period of fetal development when the fetus is most susceptible to environmental influences. A report was published. We examined in utero exposure to maternal pharmacologic hormone use in pregnancy in relation to obesity in childhood. Pregnant women who took diethylstilbestrol or oral contraceptives during specific periods of pregnancy were more likely to have obese children. The findings provide general support for the "obesogens" hypothesis. A report is in press.

饮食和其他早期接触可能会影响儿童发育和几种慢性病的风险，但还需要进一步的研究。 在这个包罗万象的项目中描述的当前研究包括一个项目，如下所述。 我们研究了在合作围产期项目中出生的后代中，妊娠期糖尿病与随后的尿道下裂和隐睾症风险之间的关系。没有发现相关性，这可能是因为妊娠期糖尿病引起的代谢障碍发生在胎儿发育时期之后，而胎儿最容易受到环境影响。发表了一份报告。 我们研究了宫内孕期母体使用药理激素与儿童肥胖的关系。在怀孕的特定时期服用己烯雌酚或口服避孕药的孕妇更有可能生下肥胖的孩子。这一发现为“肥胖患者”假说提供了普遍支持。一份报告正在出版中。

项目成果

Pharmacologic sex hormones in pregnancy in relation to offspring obesity.

妊娠期药理学性激素与后代肥胖的关系。

• DOI: 10.1002/oby.20778
• 发表时间: 2014-11
• 期刊: OBESITY
• 影响因子: 6.9
• 作者: Jensen, Elizabeth T.;Longnecker, Matthew P.
• 通讯作者: Longnecker, Matthew P.

Meeting report: measuring endocrine-sensitive endpoints within the first years of life.

• DOI: 10.1289/ehp.11226
• 发表时间: 2008-07
• 期刊: ENVIRONMENTAL HEALTH PERSPECTIVES
• 影响因子: 10.4
• 作者: Arbuckle, Tye E.;Hauser, Russ;Swan, Shanna H.;Mao, Catherine S.;Longnecker, Matthew P.;Main, Katharina M.;Whyatt, Robin M.;Mendola, Pauline;Legrand, Melissa;Rovet, Joanne;Till, Christine;Wade, Mike;Jarrell, John;Matthews, Stephen;Van Vliet, Guy;Bornehag, Carl-Gustaf;Mieusset, Roger
• 通讯作者: Mieusset, Roger

Mother's age at menarche and offspring size.

• DOI: 10.1038/ijo.2010.104
• 发表时间: 2010-12
• 期刊: INTERNATIONAL JOURNAL OF OBESITY
• 影响因子: 4.9
• 作者: Basso, O.;Pennell, M. L.;Chen, A.;Longnecker, M. P.
• 通讯作者: Longnecker, M. P.

Nephrotoxicity, neurotoxicity, and mercury exposure among children with and without dental amalgam fillings.

• DOI: 10.1016/j.ijheh.2008.09.004
• 发表时间: 2009-07
• 期刊: INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
• 影响因子: 6
• 作者: Ye, Xibiao;Qian, Haojun;Xu, Peicheng;Zhu, Lin;Longnecker, Matthew P.;Fu, Hua
• 通讯作者: Fu, Hua