NIDCR Contribution to NIH Bone Marrow Stromal Cell Transplantation Center

认识到需要创新的细胞疗法，NIDCR的领导在获得支持和筹集资金建立跨nih骨髓基质细胞移植中心方面发挥了重要作用。该中心源于一项提案，该提案由一些研究所主任选择，他们发布了一项提案，以刺激新的NIH临床中心的新活动。该中心由NIDCR、NCI、NIAID、NINDS、NIAMS、NIBIB和CC于2008年10月1日成立，其使命是建立临床级人骨髓基质细胞的制备程序，由于其对局部干细胞/祖细胞的营养作用，已被发现可以改善许多损伤和状况。该中心的资金用于在输血医学系的细胞处理实验室内建设基础设施，以体外扩增细胞并保持其生物活性。该中心在过去的11个月里取得了很大的进展，包括成功地向FDA提交了生产工艺。

Recognizing the need for innovative cell therapies, NIDCR leadership was instrumental in gaining support and raising funding for the establishment of a trans-NIH Bone Marrow Stromal Cell Transplantation Center. This Center arose from a proposal that was selected by a number of Institute Directors who issued a call for proposals that stimulate new activity in the new NIH Clinical Center. The Center was established on October 1st, 2008 by NIDCR, NCI, NIAID, NINDS, NIAMS, NIBIB and the CC. The mission of the Center is to establish the procedures for preparation of clinical grade human bone marrow stromal cells, which have been found to ameliorate a number injuries and conditions due to their trophic effect on local stem/progenitor cells. The Centers funding is for building of the infrastructure within the Cell Processing Laboratory in the Department of Transfusion Medicine to ex vivo expand the cells and still retain their biological activity. The Center has made a great deal of progress during the past 11 months, including successful submissions of manufacturing processes to the FDA.