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Genetic insights into atherosclerosis

Genetic insights into atherosclerosis
动脉粥样硬化的遗传学见解
批准号：
8557999
负责人：
PAUL M. HWANG
金额：
$44.54万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8557999
关键词：
Arterial Fatty StreakAtherosclerosisBloodBlood specimenCholesterolGeneticGenetic TechniquesGenomicsGrantHumanImmune systemInflammationLegal patentMediator of activation proteinMolecularOxidative StressOxygenProteinsRheumatoid ArthritisSeverity of illnessTIS11 proteinTissue SampleTissuesZinc Fingershuman subjectinsightnoveltumorigenesis

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中文摘要
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英文摘要
Through our genomic studies using human blood and atherosclerotic plaque tissue samples, we have identified a marker of atherosclerosis disease severity and a cholesterol-independent marker of statin treatment, which has been granted a use patent. We have also identified tristetraprolin zinc finger protein 36 (TTP) as a mediator of localized tissue inflammation important for inflammatory arthritis and atherosclerosis. Because oxidative stress is associated with inflammation, a driver of both tumorigenesis and atherosclerosis, we have initiated studies to examine the effect of ambient oxygen on atherosclerosis.
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