Genetic insights into atherosclerosis

动脉粥样硬化的遗传学见解

• 批准号: 8557999
• 负责人: PAUL M. HWANG
• 金额: $ 44.54万
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8557999
• 关键词: Arterial Fatty Streak; Atherosclerosis; Blood; Blood specimen; Cholesterol; Genetic; Genetic Techniques; Genomics; Grant; Human; Immune system; Inflammation; Legal patent; Mediator of activation protein; Molecular; Oxidative Stress; Oxygen; Proteins; Rheumatoid Arthritis; Severity of illness; TIS11 protein; Tissue Sample; Tissues; Zinc Fingers; human subject; insight; novel; tumorigenesis

Through our genomic studies using human blood and atherosclerotic plaque tissue samples, we have identified a marker of atherosclerosis disease severity and a cholesterol-independent marker of statin treatment, which has been granted a use patent. We have also identified tristetraprolin zinc finger protein 36 (TTP) as a mediator of localized tissue inflammation important for inflammatory arthritis and atherosclerosis. Because oxidative stress is associated with inflammation, a driver of both tumorigenesis and atherosclerosis, we have initiated studies to examine the effect of ambient oxygen on atherosclerosis.

通过使用人类血液和动脉粥样硬化斑块组织样本进行的基因组研究，我们已经确定了动脉粥样硬化疾病严重程度的标记和他汀类药物治疗的胆固醇非依赖性标记，并已获得使用专利。我们还发现，雷公藤红素锌指蛋白36(TTP)是局部组织炎症的介质，对炎性关节炎和动脉粥样硬化非常重要。由于氧化应激与炎症有关，炎症是肿瘤发生和动脉粥样硬化的驱动因素，我们已经开始研究环境氧对动脉粥样硬化的影响。