Effect of molecular oxygen on cardiovascular and cancer biology

分子氧对心血管和癌症生物学的影响

• 批准号: 8158038
• 负责人: PAUL M. HWANG
• 金额: $ 48.94万
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8158038
• 关键词: Cancer Biology; Cardiovascular system; DNA Damage; Disease; Molecular; Oxygen; tumorigenesis

Our current studies suggest mitochondrial dysfunction causes oxygen-associated genomic DNA damage. Because oxygen serves as an essential factor for oxidative stress, a cause of genomic instability, we have been examining the effect of modulating ambient oxygen on de novo tumorigenesis in different cancer models. As oxidative stress is also involved in inflammation, we have been examining its effect on atherosclerosis. The goal of these lines of investigation is to provide basic experimental evidence for the importance of ambient oxygen on disease pathogenesis and to obtain insights useful for developing new preventive strategies against the two major causes of human diseases.

我们目前的研究表明，线粒体功能障碍导致氧相关的基因组DNA损伤。 由于氧作为氧化应激的一个重要因素，基因组不稳定的原因，我们一直在研究调节环境氧对不同癌症模型中的从头肿瘤发生的影响。 由于氧化应激也参与炎症，我们一直在研究它对动脉粥样硬化的影响。 这些调查的目的是提供基本的实验证据的重要性，环境中的氧气对疾病的发病机制，并获得有用的见解，开发新的预防策略，对人类疾病的两个主要原因。