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Effect of molecular oxygen on cardiovascular and cancer biology

Effect of molecular oxygen on cardiovascular and cancer biology
分子氧对心血管和癌症生物学的影响
批准号：
8158038
负责人：
PAUL M. HWANG
金额：
$48.94万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8158038
关键词：
Cancer BiologyCardiovascular systemDNA DamageDiseaseMolecularOxygentumorigenesis

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中文摘要
翻译
我们目前的研究表明，线粒体功能障碍会导致氧相关的基因组DNA损伤。由于氧是氧化应激的基本因素，氧化应激是基因组不稳定的原因之一，我们一直在研究调节环境氧对不同癌症模型新生肿瘤发生的影响。由于氧化应激也与炎症有关，我们一直在研究其对动脉粥样硬化的影响。这些研究的目标是为环境氧在疾病发病机制中的重要性提供基本的实验证据，并获得有助于开发针对人类疾病的两大主要原因的新预防策略的见解。
英文摘要
Our current studies suggest mitochondrial dysfunction causes oxygen-associated genomic DNA damage. Because oxygen serves as an essential factor for oxidative stress, a cause of genomic instability, we have been examining the effect of modulating ambient oxygen on de novo tumorigenesis in different cancer models. As oxidative stress is also involved in inflammation, we have been examining its effect on atherosclerosis. The goal of these lines of investigation is to provide basic experimental evidence for the importance of ambient oxygen on disease pathogenesis and to obtain insights useful for developing new preventive strategies against the two major causes of human diseases.
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会议论文
Genetic insights into mitochondrial function, cancer and cardiovascular diseases
Effects of redox homeostasis on cancer and cardiovascular diseases
Redox homeostasis in cancer and cardiovascular diseases
Genetic insights into cardiovascular function and disease
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