Effect of molecular oxygen on cardiovascular and cancer biology
Effect of molecular oxygen on cardiovascular and cancer biology
批准号:
8158038
负责人:
PAUL M. HWANG
金额:
$48.94万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
我们目前的研究表明,线粒体功能障碍导致氧相关的基因组DNA损伤。 由于氧作为氧化应激的一个重要因素,基因组不稳定的原因,我们一直在研究调节环境氧对不同癌症模型中的从头肿瘤发生的影响。 由于氧化应激也参与炎症,我们一直在研究其对动脉粥样硬化的影响。 这些调查的目的是提供基本的实验证据的重要性,环境中的氧气对疾病的发病机制,并获得有用的见解,开发新的预防策略,对人类疾病的两个主要原因。
英文摘要
Our current studies suggest mitochondrial dysfunction causes oxygen-associated genomic DNA damage. Because oxygen serves as an essential factor for oxidative stress, a cause of genomic instability, we have been examining the effect of modulating ambient oxygen on de novo tumorigenesis in different cancer models. As oxidative stress is also involved in inflammation, we have been examining its effect on atherosclerosis. The goal of these lines of investigation is to provide basic experimental evidence for the importance of ambient oxygen on disease pathogenesis and to obtain insights useful for developing new preventive strategies against the two major causes of human diseases.
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Genetic insights into mitochondrial function, cancer and cardiovascular diseases
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批准号:7969099
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项目类别:
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资助金额:$163.84万
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财政年份:--
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负责人:PAUL M. HWANG
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依托单位:
Effects of redox homeostasis on cancer and cardiovascular diseases
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批准号:9157381
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项目类别:
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资助金额:$59.03万
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财政年份:--
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负责人:PAUL M. HWANG
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依托单位:
Redox homeostasis in cancer and cardiovascular diseases
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批准号:9550549
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项目类别:
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资助金额:$61.99万
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财政年份:--
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负责人:PAUL M. HWANG
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依托单位:
Genetic insights into cardiovascular function and disease
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批准号:7594435
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资助金额:$241.41万
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财政年份:--
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负责人:PAUL M. HWANG
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依托单位:
Redox homeostasis in cancer and cardiovascular diseases
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批准号:9339275
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项目类别:
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资助金额:$67.59万
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财政年份:--
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负责人:PAUL M. HWANG
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依托单位:
Genetic insights into atherosclerosis
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批准号:8344852
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项目类别:
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资助金额:$32.59万
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财政年份:--
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负责人:PAUL M. HWANG
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依托单位:
Mitochondrial regulation in cardiovascular and cancer biology
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批准号:8746587
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项目类别:
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资助金额:$99.55万
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财政年份:--
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负责人:PAUL M. HWANG
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依托单位:
Effects of redox homeostasis on cancer and cardiovascular diseases
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批准号:8939832
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项目类别:
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资助金额:$58.39万
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财政年份:--
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负责人:PAUL M. HWANG
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依托单位:
Genetic insights into atherosclerosis
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批准号:8557999
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项目类别:
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资助金额:$44.54万
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财政年份:--
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负责人:PAUL M. HWANG
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依托单位:
Genetic insights into cardiovascular function and disease
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批准号:7735016
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项目类别:
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资助金额:$197.67万
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财政年份:--
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负责人:PAUL M. HWANG
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依托单位:
Effect of oxygen homeostasis on cardiovascular and cancer biology
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批准号:8746628
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项目类别:
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资助金额:$59.97万
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财政年份:--
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负责人:PAUL M. HWANG
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依托单位:
Effect of molecular oxygen on cardiovascular and cancer biology
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批准号:8344853
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项目类别:
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资助金额:$48.89万
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财政年份:--
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负责人:PAUL M. HWANG
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依托单位:
Effect of molecular oxygen on cardiovascular and cancer biology
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批准号:8558000
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项目类别:
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资助金额:$66.82万
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财政年份:--
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负责人:PAUL M. HWANG
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依托单位:
Mitochondrial regulation in cardiovascular and cancer biology
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批准号:8557946
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项目类别:
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资助金额:$111.36万
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财政年份:--
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负责人:PAUL M. HWANG
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依托单位:
Genetic insights into atherosclerosis
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批准号:8746627
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项目类别:
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资助金额:$40.17万
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财政年份:--
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负责人:PAUL M. HWANG
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依托单位:
Genetic insights into cardiovascular function and diseas
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批准号:7321753
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:PAUL M. HWANG
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依托单位:
Redox and other mechanistic insights into cancer and cardiovascular diseases
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批准号:10929120
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项目类别:
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资助金额:$112.44万
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财政年份:--
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负责人:PAUL M. HWANG
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依托单位:
Mitochondrial regulation and function in cancer and cardiovascular biology
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批准号:10008774
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项目类别:
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资助金额:$134.78万
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财政年份:--
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负责人:PAUL M. HWANG
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依托单位:
Mitochondrial regulation and function in cancer and cardiovascular biology
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批准号:10253814
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项目类别:
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资助金额:$120.82万
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财政年份:--
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负责人:PAUL M. HWANG
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依托单位:
Mitochondrial regulation in cardiovascular and cancer biology
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批准号:8158031
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项目类别:
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资助金额:$97.89万
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财政年份:--
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负责人:PAUL M. HWANG
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依托单位:
海外基金