Redox and other mechanistic insights into cancer and cardiovascular diseases

关于癌症和心血管疾病的氧化还原和其他机制见解

• 批准号: 10929120
• 负责人: PAUL M. HWANG
• 金额: $ 112.44万
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10929120
• 关键词: Cardiovascular Diseases; Cardiovascular system; DNA Damage; Disease; Drug Metabolic Detoxication; Exercise; Generations; Health; Homeostasis; Human; Immune; Immune signaling; Inflammation; Maintenance; Malignant Neoplasms; Mitochondria; Myocardium; Oxidation-Reduction; Oxidative Stress; Oxygen; Reactive Oxygen Species; Role; Skeletal Muscle; Stress; Translating; Water; blood pressure elevation; improved; insight; tumorigenesis

Our previous studies have suggested that oxidative stress promotes DNA damage and tumorigenesis. Thus, we are continuing to investigate the role of the mitochondria in detoxifying oxygen, the essential substrate for reactive oxygen species generation, by its reduction to inert water. We are also investigating the role of the mitochondria in adaptation to stresses such as exercise or increased afterload in skeletal or cardiac muscle. Insights into these mechanisms that involve inflammation or innate immune signaling via the mitochondria may be helpful for developing new strategies for disease treatment or health maintenance.

我们之前的研究表明，氧化应激促进DNA损伤和肿瘤发生。因此，我们正在继续研究线粒体通过将氧还原为惰性水来解毒氧的作用。氧是产生活性氧物种的基本底物。我们还在研究线粒体在骨骼肌或心肌中对运动或增加后负荷等压力的适应中所起的作用。对这些涉及炎症或通过线粒体传递先天免疫信号的机制的深入了解，可能有助于开发新的疾病治疗或健康维护策略。

项目成果

Long-term adaptation to hypoxia preserves hematopoietic stem cell function.

长期适应缺氧可保留造血干细胞功能。

• DOI: 10.1016/j.exphem.2016.04.010
• 发表时间: 2016-09
• 期刊: Experimental hematology
• 影响因子: 2.6
• 作者: Chen J;Kang JG;Keyvanfar K;Young NS;Hwang PM
• 通讯作者: Hwang PM

Mitochondrial respiration reduces exposure of the nucleus to oxygen.

• DOI: 10.1016/j.jbc.2023.103018
• 发表时间: 2023-03
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Mori, Mateus Prates;Penjweini, Rozhin;Ma, Jin;Alspaugh, Greg;Andreoni, Alessio;Kim, Young-Chae;Wang, Ping-yuan;Knutson, Jay R.;Hwang, Paul M.
• 通讯作者: Hwang, Paul M.

p53 as guardian of the mitochondrial genome.

• DOI: 10.1002/1873-3468.12061
• 发表时间: 2016-04
• 期刊: FEBS letters
• 影响因子: 3.5
• 作者: Park JH;Zhuang J;Li J;Hwang PM
• 通讯作者: Hwang PM

Ambient oxygen promotes tumorigenesis.

• DOI: 10.1371/journal.pone.0019785
• 发表时间: 2011-05-12
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Sung HJ;Ma W;Starost MF;Lago CU;Lim PK;Sack MN;Kang JG;Wang PY;Hwang PM
• 通讯作者: Hwang PM