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Redox and other mechanistic insights into cancer and cardiovascular diseases

Redox and other mechanistic insights into cancer and cardiovascular diseases
关于癌症和心血管疾病的氧化还原和其他机制见解
批准号：
10929120
负责人：
PAUL M. HWANG
金额：
$112.44万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10929120
关键词：
Cardiovascular DiseasesCardiovascular systemDNA DamageDiseaseDrug Metabolic DetoxicationExerciseGenerationsHealthHomeostasisHumanImmuneImmune signalingInflammationMaintenanceMalignant NeoplasmsMitochondriaMyocardiumOxidation-ReductionOxidative StressOxygenReactive Oxygen SpeciesRoleSkeletal MuscleStressTranslatingWaterblood pressure elevationimprovedinsighttumorigenesis

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中文摘要
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英文摘要
Our previous studies have suggested that oxidative stress promotes DNA damage and tumorigenesis. Thus, we are continuing to investigate the role of the mitochondria in detoxifying oxygen, the essential substrate for reactive oxygen species generation, by its reduction to inert water. We are also investigating the role of the mitochondria in adaptation to stresses such as exercise or increased afterload in skeletal or cardiac muscle. Insights into these mechanisms that involve inflammation or innate immune signaling via the mitochondria may be helpful for developing new strategies for disease treatment or health maintenance.
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
Long-term adaptation to hypoxia preserves hematopoietic stem cell function.
长期适应缺氧可保留造血干细胞功能。
DOI： 10.1016/j.exphem.2016.04.010
发表时间： 2016-09
期刊： Experimental hematology
影响因子： 2.6
作者： [Chen J, Kang JG, Keyvanfar K, Young NS, Hwang PM]
通讯作者： Hwang PM
Mitochondrial respiration reduces exposure of the nucleus to oxygen.
DOI： 10.1016/j.jbc.2023.103018
发表时间： 2023-03
期刊： JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子： 4.8
作者： [Mori, Mateus Prates, Penjweini, Rozhin, Ma, Jin, Alspaugh, Greg, Andreoni, Alessio, Kim, Young-Chae, Wang, Ping-yuan, Knutson, Jay R., Hwang, Paul M.]
通讯作者： Hwang, Paul M.
p53 as guardian of the mitochondrial genome.
DOI： 10.1002/1873-3468.12061
发表时间： 2016-04
期刊： FEBS letters
影响因子： 3.5
作者： [Park JH, Zhuang J, Li J, Hwang PM]
通讯作者： Hwang PM
Ambient oxygen promotes tumorigenesis.
DOI： 10.1371/journal.pone.0019785
发表时间： 2011-05-12
期刊： PloS one
影响因子： 3.7
作者： [Sung HJ, Ma W, Starost MF, Lago CU, Lim PK, Sack MN, Kang JG, Wang PY, Hwang PM]
通讯作者： Hwang PM
Genetic insights into mitochondrial function, cancer and cardiovascular diseases
Effects of redox homeostasis on cancer and cardiovascular diseases
Redox homeostasis in cancer and cardiovascular diseases
Genetic insights into cardiovascular function and disease
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