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Effect of molecular oxygen on cardiovascular and cancer biology

Effect of molecular oxygen on cardiovascular and cancer biology
分子氧对心血管和癌症生物学的影响
批准号：
8344853
负责人：
PAUL M. HWANG
金额：
$48.89万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8344853
关键词：
AtherosclerosisBiologyCancer BiologyCancer ModelCardiovascular systemColonic PolypsDNA DamageDevelopmentDiseaseGenomic InstabilityGenomicsGoalsImmuneInflammationInvestigationLymphomaMolecularOxidative StressOxygenPathogenesisPrevention strategyRolecancer preventioncell typehuman diseaseinsightmitochondrial dysfunctionoxidative DNA damagetumorigenesis

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中文摘要
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英文摘要
Our current studies suggest mitochondrial dysfunction causes oxygen-associated genomic DNA damage. Because oxygen serves as an essential factor for oxidative stress, a cause of genomic instability, we have been examining the effect of modulating ambient oxygen on de novo tumorigenesis (e.g., lymphoma or colon polyp formation) in different cancer models. As oxidative stress is also involved in inflammation, we have been examining its effect on atherosclerosis. The goals of these investigations are to provide basic experimental evidence for the importance of ambient oxygen on disease pathogenesis and to obtain insights useful for developing new preventive strategies against the two major causes of human diseases.
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会议论文
Genetic insights into mitochondrial function, cancer and cardiovascular diseases
Effects of redox homeostasis on cancer and cardiovascular diseases
Redox homeostasis in cancer and cardiovascular diseases
Genetic insights into cardiovascular function and disease
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海外基金
Journal of Integrative Plant Biology
  • 批准号：
    31024801
  • 项目类别：
    专项基金项目
  • 资助金额：
    24.0万元
  • 批准年份：
    2010
  • 负责人：
    贺萍
  • 依托单位：
    中国科学院植物研究所