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Effects of redox homeostasis on cancer and cardiovascular diseases

Effects of redox homeostasis on cancer and cardiovascular diseases
氧化还原稳态对癌症和心血管疾病的影响
批准号：
9157381
负责人：
PAUL M. HWANG
金额：
$59.03万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9157381
关键词：
AerobicAffectBiologicalBiologyCardiovascular DiseasesCardiovascular systemCell modelCellular StressDNA DamageDevelopmentDiseaseEnergy MetabolismGeneticGenomic DNAHealthHomeostasisHumanLifeMalignant NeoplasmsMethodsMitochondriaNuclearOxidation-ReductionOxygenPathogenesisReactive Oxygen SpeciesStressmitochondrial dysfunctionmouse modelneoplastic cellpreventtumorigenesis

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英文摘要
Our previous studies have suggested that mitochondrial dysfunction causes oxidative genomic DNA damage and contributes to tumorigenesis. Oxygen is necessary for aerobic life but it also serves as the essential substrate for reactive oxygen species that can cause biological damage. We are currently using environmental and genetic methods to modulate oxygen homeostasis and to examine their effect on energy metabolism, tumorigenesis, and cardiovascular disease. We are also examining adaptive mechanisms by which cells of neoplastic or cardiovascular origin survive under oxidative or other toxic stress conditions.
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Genetic insights into mitochondrial function, cancer and cardiovascular diseases
Redox homeostasis in cancer and cardiovascular diseases
Redox homeostasis in cancer and cardiovascular diseases
Genetic insights into cardiovascular function and disease
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