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Redox homeostasis in cancer and cardiovascular diseases

Redox homeostasis in cancer and cardiovascular diseases
癌症和心血管疾病中的氧化还原稳态
批准号：
9339275
负责人：
PAUL M. HWANG
金额：
$67.59万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9339275
关键词：
AffectBiologicalBiologyCardiovascular DiseasesCardiovascular systemDNA DamageDiseaseEnergy MetabolismGenerationsGeneticGenomic DNAHomeostasisMalignant NeoplasmsMethodsOxidation-ReductionOxidative StressOxygenPathogenesisReactive Oxygen SpeciesStressmitochondrial dysfunctionneoplastic celltumorigenesis

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英文摘要
Our previous studies have suggested that mitochondrial dysfunction causes oxidative genomic DNA damage and contributes to tumorigenesis. A major contributing factor is ambient oxygen which is the essential substrate for reactive oxygen species generation that can cause biological damage. Environmental and genetic methods will be used to modulate redox homeostasis and to determine their effect on energy metabolism, tumorigenesis, and cardiovascular disease. We are examining adaptive mechanisms by which cells of neoplastic or cardiovascular origin survive under oxidative or other toxic stress conditions.
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Genetic insights into mitochondrial function, cancer and cardiovascular diseases
Effects of redox homeostasis on cancer and cardiovascular diseases
Redox homeostasis in cancer and cardiovascular diseases
Genetic insights into cardiovascular function and disease
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