Training in Dengue Prevention and Control

描述（由申请人提供）：这是对2009年9月提交的Fogarty培训资助提案“登革热预防和控制培训”的修订，该提案旨在为科罗拉多州立大学的墨西哥博士生和博士后学生建立一个国际传染病培训项目。拟议的GIDRTP的重点是提供关于控制登革热病毒（DENV1-4）蚊媒埃及伊蚊的现代方法的关键培训，并随后预防流行性登革热（DF）和登革出血热（DHF）。这两种疾病已成为美洲的主要公共卫生问题。该提案最初是在去年与一项国际传染病研究合作（ICIDR）赠款“埃及伊蚊和登革热流行的可持续控制”申请一起提交的。这项ICIDR资助是由蒙特雷联合国大学的德拉·弗洛雷斯-苏亚雷斯（Dra a . Flores-Suarez）和梅里达美国大学的法尔凡-阿勒（Farfan-Ale）博士共同研究的，于2010年9月获得并开始实施。因此，如果这个Fogerty申请得到资助，我们准备继续培训来自墨西哥的博士后和博士生，用最新的方法来控制Ae。以及随后的登革热和登革出血热预防。拟议的培训计划将是灵活的，将允许专业课程和实验室或实地项目中的四个轨道之一：1)蚊子监测和控制，2)杀虫剂抗性管理，3)效应分子开发或4)遗传控制。尽管有这种灵活性，所有学生都将直接参与到登革热决策支持系统（DDSS）中，该系统正在科罗拉多州立大学积极开发，实时收集登革热患者、实验室诊断、蚊子数量和杀虫剂抗性的数据。DDSS的目的是支持病媒/疾病控制项目，提高这些项目的能力，以便：1)收集、储存、管理和分析与蚊子病媒和疾病有关的数据；2)产生信息丰富的分析输出（图表、图形、地图、表格），以支持决策；3)实施适合当地的病媒/疾病控制项目战略和方法。最终，学生在返回墨西哥后也可能负责在自己的州建立和维护DDSS。

DESCRIPTION (provided by applicant): This is a revision of a Fogarty training grant proposal "Training in Dengue Prevention and Control" submitted in September of 2009 to build an international infectious disease training program for Mexican predoctoral and postdoctoral students at Colorado State University. The focus of the proposed GIDRTP is to provide critical training in modern approaches for control of the dengue virus (DENV1-4) mosquito vector Aedes aegypti and subsequent prevention of epidemic dengue fever (DF) and Dengue Hemorrhagic Fever (DHF). Both diseases have emerged as major public health problems in the Americas. This proposal was originally submitted last year in conjunction with an application for an International Collaborations in Infectious Disease Research (ICIDR) grant "Sustainable control of Aedes aegypti and epidemic dengue." That ICIDR grant, a collaboration with coinvestigators Dra A. Flores-Suarez from UANL in Monterrey, and Dr. Farfan-Ale from UADY in Merida was awarded and began in September 2010. Thus, if this Fogerty application is funded, we are poised to continue to train pre- and postdoctoral student from Mexico in the most up to date methods to control the Ae. aegypti and subsequent prevention of DF and DHF. The proposed training program will be flexible and will permit specialized coursework and laboratory or field projects in one of four tracks: 1) mosquito monitoring and control, 2) insecticide resistance management, 3) effector molecule development or 4) genetic control. Despite this flexibility all students will become directly involved in populating the Dengue Decision Support System (DDSS) which is being actively developed at CSU with data on dengue patients, laboratory diagnostics, mosquito abundance, and insecticide resistance collected in real time. The DDSS aims to support operational vector/disease control programs by increasing their capacity to: 1) collect, store, manage, and analyze mosquito vector- and disease-related data, 2) produce informative analysis outputs (charts, graphs, maps, tables) to support decision-making, and 3) implement locally appropriate vector/disease control program strategies and methodologies. Ultimately students may also become responsible for establishing and maintaining the DDSS in their own states upon their return to Mexico. PUBLIC HEALTH RELEVANCE: In Mexico and most of Latin America, dengue has re-emerged as a public health problem. The most recent dengue epidemic in Mexico during 2005-2008 resulted in more than 100,000 reported Dengue Fever (DF) cases and >22,000 and Dengue Hemorrhagic Fever (DHF) cases. This is in stark contrast to dengue outbreaks in the 1980's and 1990's which resulted in very few DHF cases. Most of Latin America is now in a very dangerous situation with dengue hyper- endemnicity and increasing disease severity. The focus of this training grant is to provide critical training in modern approaches for control of the dengue virus (DENV1-4) mosquito vector Aedes aegypti and subsequent prevention of epidemic DF and DHF. Current control measures used against Ae. aegypti include source reduction and larvicidal control to reduce larval populations and space spraying to control adults. However, these have not proven to be sufficient or sustainable to stem the tide of DF and DHF. New approaches and tools are sorely needed to control Ae. aegypti in Latin America and indeed most of the tropical and subtropical world.