Sustainable Control of Aedes aegypti and epidemic dengue

埃及伊蚊和流行性登革热的可持续控制

• 批准号: 8688883
• 负责人: WILLIAM C. BLACK
• 金额: $ 62.88万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8688883
• 关键词: Address; Adolescent; Adult; Aedes; Affect; Americas; Area; Biological Assay; Biosensor; Characteristics; Cities; Colorado; Communities; Culicidae; Data; Dengue; Dengue Hemorrhagic Fever; Dengue Virus; Domiciles; Effectiveness; Enrollment; Epidemic; Epidemiologic Studies; Epidemiology; Evaluation; Evolution; Feeds; Female; Filariasis; Frequencies; Genes; Goals; Home environment; Household; Housing; Human; Individual; Infection; Insecticides; Institution; Intervention; Intervention Studies; Malaria; Measures; Mexico; Modeling; Molecular Genetics; Mutation; Outcome; Outcome Study; Participant; Prevention; Principal Investigator; Public Health; Randomized; Resistance; Resistance profile; Seasons; Sodium Channel; Source; Technology; Universities; Vaccines; Vector-transmitted infectious disease; Virus; Virus Diseases; arm; decamethrin; design; feeding; knock-down; metropolitan; novel strategies; pathogen; prevent; programs; pyrethroid; stem; tool; transmission process; vector; vector control; vector mosquito; vector transmission; voltage

DESCRIPTION (provided by applicant): Epidemic dengue fever and dengue hemorrhagic fever are major public health problems in the Americas. Current control measures used against the primary dengue virus (DENV) mosquito vector, Aedes aegypti, include source reduction to control juveniles and space spraying to control adults. This has not proven to be sufficient or sustainable to stem the tide of dengue. New approaches are needed to control Ae. aegypti and prevent dengue infections. Aedes aegypti feeds predominantly indoors and almost exclusively on humans. The Casa Segura ("safe house") exploits long-lasting insecticide-treated materials in the form of deltamethrin-treated curtains to preclude Ae. aegypti from the home: the epidemiologically most significant point of contact between this vector and humans. The Casa Segura prevents infected vectors from entering homes and transmitting DENV to humans or uninfected vectors from becoming infected when feeding on DENV-infected humans in the home, thereby interrupting virus transmission at two points in the mosquito-human cycle. Casa Segura offers the exciting promise of sustainable prevention and perhaps even local elimination of dengue. The effectiveness of the Casa Segura to reduce dengue is predicated upon operational effectiveness of pyrethroid insecticides. Knock-down resistance (kdr) to pyrethroids has emerged in Ae. aegypti in the tropical world, but little is known about the extent to which this may adversely affect operational vector control. In this ICIDR program, we will: 1) demonstrate in a metropolitan setting (Merida, Mexico) that the Casa Segura reduces indoor abundance of DENV-infected Ae. aegypti females and dengue infections among the residents, 2) reveal the potential operational effects of kdr on the entomological and epidemiological study outcomes, and 3) determine if the Casa Segura promotes evolution of kdr in Ae. aegypti. The ICIDR consortium will include Colorado State University, Universidad Autonoma de Nuevo Leon, and Universidad Autonoma de Yucatan. Our overarching goals are to: 1) develop a broadly applicable, inexpensive and sustainable approach to make homes in the developing world as safe as those in the developed world from transmission of vector-borne pathogens, and 2) to transfer tools and technologies to our consortium and other institutions in dengue-endemic areas. RELEVANCE : The emergence of epidemic dengue fever and dengue hemorrhagic fever in the Americas is a public health catastrophe. There is no vaccine for dengue; thus more effective vector control is critical. The Casa Segura potentially provides a long term inexpensive approach to preventing dengue virus transmission in the home. The approach may also be applicable to other globally important vector borne diseases, such as malaria, filariasis, and Chagas, which are also transmitted principally in the home.

描述（由申请人提供）：流行性登革热和登革出血热是美洲的主要公共卫生问题。目前针对主要登革热病毒 (DENV) 蚊媒埃及伊蚊的控制措施包括减少源头以控制幼蚊，以及通过空间喷洒来控制成蚊。事实证明，这不足以或可持续地阻止登革热的流行。需要新的方法来控制AE。埃及伊蚊并预防登革热感染。埃及伊蚊主要在室内进食，几乎只以人类为食。 Casa Segura（“安全屋”）采用经溴氰菊酯处理的长效杀虫剂处理材料来防止伊蚊。来自家中的埃及伊蚊：该病媒与人类之间流行病学上最重要的接触点。 Casa Segura 可防止受感染的媒介进入家庭并将 DENV 传播给人类，或防止未感染的媒介在在家中以感染 DENV 的人类为食时被感染，从而在蚊子-人类循环的两个点上中断病毒传播。 Casa Segura 提供了可持续预防甚至局部消除登革热的令人兴奋的承诺。 Casa Segura 减少登革热的有效性取决于拟除虫菊酯杀虫剂的使用效果。伊蚊已出现对拟除虫菊酯的击倒抗性 (kdr)。热带世界中存在埃及伊蚊，但人们对这可能对媒介控制操作产生不利影响的程度知之甚少。在此 ICIDR 计划中，我们将： 1) 在大都市环境（墨西哥梅里达）证明 Casa Segura 减少室内感染登革热病毒的白伊蚊数量。雌性埃及伊蚊和居民中的登革热感染，2) 揭示 kdr 对昆虫学和流行病学研究结果的潜在操作影响，以及 3) 确定 Casa Segura 是否促进埃及伊蚊中 kdr 的进化。埃及伊蚊。 ICIDR 联盟将包括科罗拉多州立大学、新莱昂自治大学和尤卡坦自治大学。我们的总体目标是：1) 开发一种广泛适用、廉价且可持续的方法，使发展中国家的家庭与发达国家的家庭一样安全，免受媒介传播病原体的传播；2) 向我们的联盟和登革热流行地区的其他机构转让工具和技术。 相关性：美洲流行性登革热和登革出血热的出现是一场公共卫生灾难。没有针对登革热的疫苗；因此，更有效的病媒控制至关重要。 Casa Segura 可能提供一种长期廉价的方法来预防登革热病毒在家中传播。该方法也可能适用于其他全球重要的媒介传播疾病，例如疟疾、丝虫病和恰加斯病，这些疾病也主要在家庭中传播。

项目成果

QTL mapping of genome regions controlling temephos resistance in larvae of the mosquito Aedes aegypti.

• DOI: 10.1371/journal.pntd.0003177
• 发表时间: 2014-10
• 期刊: PLoS neglected tropical diseases
• 影响因子: 3.8
• 作者: Reyes-Solis Gdel C;Saavedra-Rodriguez K;Suarez AF;Black WC 4th
• 通讯作者: Black WC 4th

Household use of insecticide consumer products in a dengue-endemic area in México.

• DOI: 10.1111/tmi.12364
• 发表时间: 2014-10
• 期刊: Tropical medicine & international health : TM & IH
• 作者: Loroño-Pino MA;Chan-Dzul YN;Zapata-Gil R;Carrillo-Solís C;Uitz-Mena A;García-Rejón JE;Keefe TJ;Beaty BJ;Eisen L
• 通讯作者: Eisen L

Wide spread cross resistance to pyrethroids in Aedes aegypti (Diptera: Culicidae) from Veracruz state Mexico.

• DOI: 10.1603/ec12284
• 发表时间: 2013-04
• 期刊: Journal of economic entomology
• 影响因子: 2.2
• 作者: Flores AE;Ponce G;Silva BG;Gutierrez SM;Bobadilla C;Lopez B;Mercado R;Black WC 4th
• 通讯作者: Black WC 4th

Susceptibility to chlorpyrifos in pyrethroid-resistant populations of Aedes aegypti (Diptera: Culicidae) from Mexico.

• DOI: 10.1603/me13185
• 发表时间: 2014-05
• 期刊: Journal of medical entomology
• 影响因子: 2.1
• 作者: Lopez B;Ponce G;Gonzalez JA;Gutierrez SM;Villanueva OK;Gonzalez G;Bobadilla C;Rodriguez IP;Black WC 4th;Flores AE
• 通讯作者: Flores AE

Transcription of detoxification genes after permethrin selection in the mosquito Aedes aegypti.

• DOI: 10.1111/j.1365-2583.2011.01113.x
• 发表时间: 2012-02
• 期刊: Insect molecular biology
• 影响因子: 2.6
• 作者: Saavedra-Rodriguez K;Suarez AF;Salas IF;Strode C;Ranson H;Hemingway J;Black WC 4th
• 通讯作者: Black WC 4th