DEVELOPMENT OF RESPIRATORY VIRUS INFECTION STRATEGIES FOR RHESUS MACAQUE AIRWAYS
恒河猴呼吸道呼吸道病毒感染策略的制定
基本信息
- 批准号:8357293
- 负责人:
- 金额:$ 2.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-05-01 至 2012-04-30
- 项目状态:已结题
- 来源:
- 关键词:Animal ModelAsthmaCaliforniaCellsChildChronicClinicalDevelopmentEtiologyExperimental Animal ModelFundingGoalsGrantHumanHuman respiratory syncytial virusImmuneImmune systemIn VitroInfectionLungMacaca mulattaModelingMonkeysNational Center for Research ResourcesPhysiologicalPredispositionPrimatesPrincipal InvestigatorResearchResearch InfrastructureResourcesRespiratory Syncytial Virus InfectionsRespiratory Tract InfectionsRhinovirusRodent ModelRoleSourceSymptomsUnited States National Institutes of HealthVaccinesViralairway inflammationcostin vivopostnatalpreventrespiratory infection virusrespiratory virus
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Our primary objective is to understand the pathogenic role of respiratory virus infection in the etiology of asthma and exacerbation of chronic airways inflammation in humans. Our secondary objective is to develop effective and safe vaccine approaches to prevent respiratory syncytial virus infection in young children. We propose that basic immune and physiologic mechanisms for respiratory virus pathobiology in the lung can only be elucidated using an in vivo animal model of infection. Although rodent models have been developed for respiratory virus infection, this species does not effectively duplicate the postnatal development of both lung and immune systems in primates. Our goal is to develop an experimental animal model of human respiratory syncytial virus and human rhinovirus infection using the rhesus macaque monkey (Macaca mulatta). Towards this end, the first step is to optimize the susceptibility of rhesus monkeys to human respiratory virus infection. We hypothesize that the development of a respiratory infection model that demonstrates human clinical symptoms will require in vitro passaging of human viral isolates in rhesus cells to obtain robust viral replication in monkey airways.
这个子项目是许多利用资源的研究子项目之一
由NIH/NCRR资助的中心拨款提供。子项目的主要支持
而子项目的主要调查员可能是由其他来源提供的,
包括其它NIH来源。 列出的子项目总成本可能
代表子项目使用的中心基础设施的估计数量,
而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。
我们的主要目的是了解呼吸道病毒感染在人类哮喘病因学和慢性气道炎症加重中的致病作用。我们的第二个目标是开发有效和安全的疫苗方法来预防幼儿呼吸道合胞病毒感染。我们认为,呼吸道病毒在肺部的病理生物学的基本免疫和生理机制只能通过体内动物感染模型来阐明。尽管已经开发了呼吸道病毒感染的啮齿动物模型,但该物种不能有效地复制灵长类动物的肺和免疫系统的出生后发育。我们的目标是建立一个实验动物模型,人呼吸道合胞病毒和人鼻病毒感染恒河猴(Macaca mulatta)。为此,第一步是优化恒河猴对人类呼吸道病毒感染的易感性。我们假设,开发一个呼吸道感染模型,证明人类的临床症状,将需要在恒河猴细胞中体外传代的人病毒分离株,以获得强大的病毒复制在猴气道。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
LISA M MILLER其他文献
LISA M MILLER的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('LISA M MILLER', 18)}}的其他基金
The Role of Copper in Cerebral Amyloid Angiopathy
铜在脑淀粉样血管病中的作用
- 批准号:
9919005 - 财政年份:2017
- 资助金额:
$ 2.52万 - 项目类别:
The Role of Copper in Cerebral Amyloid Angiopathy
铜在脑淀粉样血管病中的作用
- 批准号:
9173698 - 财政年份:2016
- 资助金额:
$ 2.52万 - 项目类别:
The Role of Copper in Cerebral Amyloid Angiopathy
铜在脑淀粉样血管病中的作用
- 批准号:
9305169 - 财政年份:2016
- 资助金额:
$ 2.52万 - 项目类别:
DEVELOPMENT MOLECULARBIOMARKERS: MEASURE ENVIRONMENTALLY INDUCED IMMUNE RESPONSE
发育分子生物标志物:测量环境诱导的免疫反应
- 批准号:
8357300 - 财政年份:2011
- 资助金额:
$ 2.52万 - 项目类别:
METALLATION LEVELS OF PROTEIN AGGREGATES FORMED IN AMYOTROPHIC LATERAL SCLEROSIS
肌萎缩侧索硬化症中形成的蛋白质聚集体的金属化水平
- 批准号:
8361310 - 财政年份:2011
- 资助金额:
$ 2.52万 - 项目类别:
DEVELOPMENT MOLECULARBIOMARKERS: MEASURE ENVIRONMENTALLY INDUCED IMMUNE RESPONSE
发育分子生物标志物:测量环境诱导的免疫反应
- 批准号:
8172575 - 财政年份:2010
- 资助金额:
$ 2.52万 - 项目类别:
DEVELOPMENT OF RESPIRATORY VIRUS INFECTION STRATEGIES FOR RHESUS MACAQUE AIRWAYS
恒河猴呼吸道呼吸道病毒感染策略的制定
- 批准号:
8172568 - 财政年份:2010
- 资助金额:
$ 2.52万 - 项目类别:
相似海外基金
Defining new asthma phenotypes using high-dimensional data
使用高维数据定义新的哮喘表型
- 批准号:
2901112 - 财政年份:2024
- 资助金额:
$ 2.52万 - 项目类别:
Studentship
Air pollution and Asthma in Canada: Projections of burden and the value of climate adaptation strategies
加拿大的空气污染和哮喘:负担预测和气候适应战略的价值
- 批准号:
485322 - 财政年份:2023
- 资助金额:
$ 2.52万 - 项目类别:
Operating Grants
Data-driven model links BMIz to gene expression in pediatric asthma
数据驱动模型将 BMIz 与小儿哮喘基因表达联系起来
- 批准号:
493135 - 财政年份:2023
- 资助金额:
$ 2.52万 - 项目类别:
BIOlogic drug safety and effectiveness interNational pharmacoepidemiologIC study in pregnant women with autoimmune disorders and asthma and their children (BIONIC)
患有自身免疫性疾病和哮喘的孕妇及其子女的生物药物安全性和有效性国际药物流行病学研究(BIONIC)
- 批准号:
493526 - 财政年份:2023
- 资助金额:
$ 2.52万 - 项目类别:
Operating Grants
Engaging Patient and Caregivers in Using Patient-reported Outcomes Measures in Pediatric Clinical Care for Asthma
让患者和护理人员参与儿科哮喘儿科临床护理中患者报告的结果测量
- 批准号:
495593 - 财政年份:2023
- 资助金额:
$ 2.52万 - 项目类别:
Basophilic oncostatin M fuels nociceptor neuron-induced asthma
嗜碱性制瘤素 M 促进伤害感受器神经元诱发哮喘
- 批准号:
485504 - 财政年份:2023
- 资助金额:
$ 2.52万 - 项目类别:
Salary Programs
Mechanistic Study of Inspiratory Training in Childhood Asthma
儿童哮喘吸气训练机制研究
- 批准号:
10637048 - 财政年份:2023
- 资助金额:
$ 2.52万 - 项目类别:
Early life exposure to metal mixtures: impacts on asthma and lungdevelopment
生命早期接触金属混合物:对哮喘和肺部发育的影响
- 批准号:
10678307 - 财政年份:2023
- 资助金额:
$ 2.52万 - 项目类别:
Lung resident Treg suppression of Th2 resident memory T cells in allergic asthma
过敏性哮喘中肺常驻 Treg 对 Th2 常驻记忆 T 细胞的抑制
- 批准号:
10664599 - 财政年份:2023
- 资助金额:
$ 2.52万 - 项目类别:
Obesity and Childhood Asthma: The Role of Adipose Tissue
肥胖和儿童哮喘:脂肪组织的作用
- 批准号:
10813753 - 财政年份:2023
- 资助金额:
$ 2.52万 - 项目类别: