DEVELOPMENT MOLECULARBIOMARKERS: MEASURE ENVIRONMENTALLY INDUCED IMMUNE RESPONSE

发育分子生物标志物：测量环境诱导的免疫反应

• 批准号: 8172575
• 负责人: LISA M MILLER
• 金额: $ 15.21万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172575
• 关键词: Asthma; Biological; Biological Assay; Biological Markers; Cell physiology; Cells; Computer Retrieval of Information on Scientific Projects Database; Development; Differentiation Antigens; Disease; Funding; Grant; Human; Hypersensitivity; Immune; Immune response; Institution; Leukocytes; Measures; Population; Research; Research Personnel; Resources; Reverse Transcriptase Polymerase Chain Reaction; Sampling; Source; United States National Institutes of Health; cytokine

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this study is to establish a panel of immune biomarkers that will be used to detect environmentally induced disease in humans, focusing on parameters of allergy and asthma. The panel of immune biomarkers will be developed by completion of the following two specific aims: (1) Develop a high-throughput quantitative RT-PCR assay for leukocyte cluster of differentiation markers to measure key immune cell populations associated with allergy and asthma in small biological samples and (2) Develop a high-throughput quantitative RT-PCR assay for key cytokine markers associated with allergy and asthma to measure immune cell function in small biological samples.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是建立一组免疫生物标记物，用于检测环境引起的人类疾病，重点是过敏和哮喘的参数。免疫生物标记物小组将通过完成以下两个具体目标来开发：(1)开发一种高通量的白细胞分化标记物的定量RT-PCR检测方法，以测量小生物样品中与过敏和哮喘相关的关键免疫细胞群；(2)开发一种高通量的与过敏和哮喘相关的关键细胞因子标记物的RT-PCR检测方法，以测量小生物样品中的免疫细胞功能。