DEVELOPMENT MOLECULARBIOMARKERS: MEASURE ENVIRONMENTALLY INDUCED IMMUNE RESPONSE

发育分子生物标志物：测量环境诱导的免疫反应

• 批准号: 8172575
• 负责人: LISA M MILLER
• 金额: $ 15.21万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172575
• 关键词: Asthma; Biological; Biological Assay; Biological Markers; Cell physiology; Cells; Computer Retrieval of Information on Scientific Projects Database; Development; Differentiation Antigens; Disease; Funding; Grant; Human; Hypersensitivity; Immune; Immune response; Institution; Leukocytes; Measures; Population; Research; Research Personnel; Resources; Reverse Transcriptase Polymerase Chain Reaction; Sampling; Source; United States National Institutes of Health; cytokine

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this study is to establish a panel of immune biomarkers that will be used to detect environmentally induced disease in humans, focusing on parameters of allergy and asthma. The panel of immune biomarkers will be developed by completion of the following two specific aims: (1) Develop a high-throughput quantitative RT-PCR assay for leukocyte cluster of differentiation markers to measure key immune cell populations associated with allergy and asthma in small biological samples and (2) Develop a high-throughput quantitative RT-PCR assay for key cytokine markers associated with allergy and asthma to measure immune cell function in small biological samples.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是建立一组免疫生物标志物，该小组将用于检测人类中环境诱导的疾病，重点关注过敏和哮喘的参数。 The panel of immune biomarkers will be developed by completion of the following two specific aims: (1) Develop a high-throughput quantitative RT-PCR assay for leukocyte cluster of differentiation markers to measure key immune cell populations associated with allergy and asthma in small biological samples and (2) Develop a high-throughput quantitative RT-PCR assay for key cytokine markers associated with allergy and asthma to measure小型生物样品中的免疫细胞功能。