EARLY IMMUNE EVENTS IN CHILDHOOD ASTHMA

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 该项目的主要目标是利用过敏性呼吸道疾病的恒河猴模型，确定引发儿童哮喘临床症状发展的早期肺部机制。我们假设肺嗜酸性粒细胞增多症是在出生后发育过程中引起过敏性呼吸道疾病的关键的第一步。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The primary objective of this project is to determine the early pulmonary mechanisms that initiate development of clinical symptoms in childhood asthma, using a rhesus monkey model of allergic airways disease. We have hypothesized that pulmonary eosinophilia is a critical first step in the initiation of allergic airways disease during postnatal development.