ROLE OF EPITHELIUM IN AIRWAY IMMUNITY

上皮在气道免疫中的作用

基本信息

  • 批准号:
    8172602
  • 负责人:
  • 金额:
    $ 15.21万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-06-01 至 2011-04-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Little is known about the antecedent events within the human infant lung that predispose the development of pathologic immune responses to inhaled allergens later in life. We do not know if the structural cells of the infant lung can significantly influence the phenotype of an immune response to an inhaled environmental challenge. Of particular significance is the epithelial cell of the conducting airways, which is architecturally and functionally poised to serve as a liaison to the adaptive immune system. The primary objective of this proposal is to determine how the conducting airway epithelium of the infant lung can influence the adaptive immune response to inhaled allergens. Our overall hypothesis is that epithelial cells of the infant lung play a central role in the initiation of the asthma phenotype, via constitutive CCL20 chemokine expression to promote airways recruitment of chemokine receptor CCR6+ T lymphocytes. This hypothesis is based on preliminary data obtained from airway epithelial cell cultures, demonstrating age-dependent expression and inhibitory microRNA regulation of CCL20 via IL-17A. We have also identified a population of IL-17A-producing CCR6+ T lymphocytes in airways of allergen-exposed infant monkeys. Given that human dendritic cells are deficient in IL-12 (a potent inhibitor of IL-17A) during infancy, we further hypothesize that development of the asthma phenotype is initially mediated not by an imbalance of Th2/Th1 cytokines, but rather an imbalance of IL-17A/IL-12. To test these hypotheses, we will 1) investigate the developmental regulation of CCL20 expression in infant airway epithelium, 2) characterize chemokine receptor CCR6+ lymphocyte populations in the infant monkey lung following allergen exposure, and 3) determine the impact of IL-17/IL-12 imbalance on allergen exposed infant monkeys. The experiments proposed within this application will contribute to our overall understanding of how the epithelium of the maturing postnatal lung can direct the development of a pathologic immune response to inhaled allergens. Our findings regarding the contribution of IL-17A in development of asthma in the non-human primate can be directly extrapolated towards identification of candidate drugs for the prevention of childhood asthma. The experiments proposed within this application will contribute to our overall understanding of how the epithelium of the maturing postnatal lung can direct the development of a pathologic immune response to inhaled allergens. Our findings regarding the contribution of IL-17A in the development of the asthma phenotype in non-human primates can be directly extrapolated towards identification of candidate drugs for the prevention of childhood asthma.
这个子项目是众多研究子项目之一

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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LISA M MILLER其他文献

LISA M MILLER的其他文献

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{{ truncateString('LISA M MILLER', 18)}}的其他基金

The Role of Copper in Cerebral Amyloid Angiopathy
铜在脑淀粉样血管病中的作用
  • 批准号:
    9919005
  • 财政年份:
    2017
  • 资助金额:
    $ 15.21万
  • 项目类别:
The Role of Copper in Cerebral Amyloid Angiopathy
铜在脑淀粉样血管病中的作用
  • 批准号:
    9173698
  • 财政年份:
    2016
  • 资助金额:
    $ 15.21万
  • 项目类别:
The Role of Copper in Cerebral Amyloid Angiopathy
铜在脑淀粉样血管病中的作用
  • 批准号:
    9305169
  • 财政年份:
    2016
  • 资助金额:
    $ 15.21万
  • 项目类别:
ROLE OF EPITHELIUM IN AIRWAY IMMUNITY
上皮在气道免疫中的作用
  • 批准号:
    8357321
  • 财政年份:
    2011
  • 资助金额:
    $ 15.21万
  • 项目类别:
DEVELOPMENT MOLECULARBIOMARKERS: MEASURE ENVIRONMENTALLY INDUCED IMMUNE RESPONSE
发育分子生物标志物:测量环境诱导的免疫反应
  • 批准号:
    8357300
  • 财政年份:
    2011
  • 资助金额:
    $ 15.21万
  • 项目类别:
DEVELOPMENT OF RESPIRATORY VIRUS INFECTION STRATEGIES FOR RHESUS MACAQUE AIRWAYS
恒河猴呼吸道呼吸道病毒感染策略的制定
  • 批准号:
    8357293
  • 财政年份:
    2011
  • 资助金额:
    $ 15.21万
  • 项目类别:
METALLATION LEVELS OF PROTEIN AGGREGATES FORMED IN AMYOTROPHIC LATERAL SCLEROSIS
肌萎缩侧索硬化症中形成的蛋白质聚集体的金属化水平
  • 批准号:
    8361310
  • 财政年份:
    2011
  • 资助金额:
    $ 15.21万
  • 项目类别:
EARLY IMMUNE EVENTS IN CHILDHOOD ASTHMA
儿童哮喘的早期免疫事件
  • 批准号:
    8357279
  • 财政年份:
    2011
  • 资助金额:
    $ 15.21万
  • 项目类别:
DEVELOPMENT MOLECULARBIOMARKERS: MEASURE ENVIRONMENTALLY INDUCED IMMUNE RESPONSE
发育分子生物标志物:测量环境诱导的免疫反应
  • 批准号:
    8172575
  • 财政年份:
    2010
  • 资助金额:
    $ 15.21万
  • 项目类别:
DEVELOPMENT OF RESPIRATORY VIRUS INFECTION STRATEGIES FOR RHESUS MACAQUE AIRWAYS
恒河猴呼吸道呼吸道病毒感染策略的制定
  • 批准号:
    8172568
  • 财政年份:
    2010
  • 资助金额:
    $ 15.21万
  • 项目类别:

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Fourier decomposition free-breathing 1H MRI perfusion maps in asthma
哮喘的傅里叶分解自由呼吸 1H MRI 灌注图
  • 批准号:
    400297
  • 财政年份:
    2019
  • 资助金额:
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California Breathing Asthma Program
加州呼吸哮喘计划
  • 批准号:
    9119510
  • 财政年份:
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  • 项目类别:
The Breathing for Life Trial (BLT): A randomised trial of fractional exhaled nitric oxide based management of asthma during pregnancy and its impact on perinatal outcomes and infant and childhood respiratory health
生命呼吸试验 (BLT):一项随机试验,研究基于呼气一氧化氮分数的妊娠期哮喘管理及其对围产期结局以及婴儿和儿童呼吸健康的影响
  • 批准号:
    nhmrc : 1060983
  • 财政年份:
    2014
  • 资助金额:
    $ 15.21万
  • 项目类别:
    Project Grants
Sleep Disordered Breathing and Asthma Morbidity in Inner City School Children
内城学童的睡眠呼吸障碍和哮喘发病率
  • 批准号:
    8784367
  • 财政年份:
    2014
  • 资助金额:
    $ 15.21万
  • 项目类别:
California Breathing Asthma Program
加州呼吸哮喘计划
  • 批准号:
    8895100
  • 财政年份:
    2014
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    $ 15.21万
  • 项目类别:
What are the lifetime clinical predictors and risk factors for multiple phenotypes of adult Asthma, COPD and Sleep Disordered Breathing? Following up the TAHS cohort from 1st to 6th decade
成人哮喘、慢性阻塞性肺病和睡眠呼吸障碍多种表型的终生临床预测因素和危险因素是什么?
  • 批准号:
    nhmrc : 1021275
  • 财政年份:
    2012
  • 资助金额:
    $ 15.21万
  • 项目类别:
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CALIFORNIA BREATHING ASTHMA PROGRAM/CALIFORNIA DEPT OF PUBLIC HEALTH
加州呼吸哮喘计划/加州公共卫生部
  • 批准号:
    8328114
  • 财政年份:
    2009
  • 资助金额:
    $ 15.21万
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CALIFORNIA BREATHING ASTHMA PROGRAM/CALIFORNIA DEPT OF PUBLIC HEALTH
加州呼吸哮喘计划/加州公共卫生部
  • 批准号:
    8135198
  • 财政年份:
    2009
  • 资助金额:
    $ 15.21万
  • 项目类别:
CALIFORNIA BREATHING ASTHMA PROGRAM/CALIFORNIA DEPT OF PUBLIC HEALTH
加州呼吸哮喘计划/加州公共卫生部
  • 批准号:
    7842022
  • 财政年份:
    2009
  • 资助金额:
    $ 15.21万
  • 项目类别:
CALIFORNIA BREATHING ASTHMA PROGRAM/CALIFORNIA DEPT OF PUBLIC HEALTH
加州呼吸哮喘计划/加州公共卫生部
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    7924810
  • 财政年份:
    2009
  • 资助金额:
    $ 15.21万
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