USING BOTULINUM NEUROTOXINS TO DEFINE ESSENTIAL PRESYNAPTIC FUNCTIONS

这个子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心拨款提供。次级项目的主要支助 子项目的主要研究者可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 表示子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 了解微生物病原体如何破坏关键细胞功能的确切机制不仅可以成功治疗感染，还可以为科学家提供强大的工具来探索基本的细胞过程。在这个项目中，我们将研究一组细菌毒素是如何  肉毒神经毒素  导致神经元退化。目标是揭示BoNT靶向的突触前功能，这对于维持轴突的完整性和神经元的存活至关重要。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Understanding the precise mechanism of how microbial pathogens disrupt critical cellular function leads not only to successful treatment of infections, but also gives scientists powerful tools to probe fundamental cellular processes. In this project, we will investigate how a group of bacterial toxins  botulinum neurotoxins (BoNTs)  induces degeneration of neurons. The goal is to uncover the presynaptic function, targeted by BoNTs, that is essential for maintaining the integrity of axons and survival of neurons.