USING BOTULINUM NEUROTOXINS TO DEFINE ESSENTIAL PRESYNAPTIC FUNCTIONS

使用肉毒杆菌神经毒素定义基本的突触前功能

• 批准号: 8357969
• 负责人: Min Dong
• 金额: $ 1.38万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357969
• 关键词: Axon; Bacterial Toxins; Bontoxilysin; Cell physiology; Funding; Goals; Grant; Infection; National Center for Research Resources; Nerve Degeneration; Neurons; New England; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Scientist; Source; United States National Institutes of Health; base; cost; microbial; pathogen; presynaptic; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Understanding the precise mechanism of how microbial pathogens disrupt critical cellular function leads not only to successful treatment of infections, but also gives scientists powerful tools to probe fundamental cellular processes. In this project, we will investigate how a group of bacterial toxins  botulinum neurotoxins (BoNTs)  induces degeneration of neurons. The goal is to uncover the presynaptic function, targeted by BoNTs, that is essential for maintaining the integrity of axons and survival of neurons.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 了解微生物病原体如何破坏关键细胞功能的确切机制不仅能成功治疗感染，还能为科学家提供强大的工具来探索基本的细胞过程。在这个项目中，我们将研究一组细菌毒素肉毒杆菌神经毒素(BoNTs)如何诱导神经元变性。其目标是揭示BoNTs靶向的突触前功能，这对维持轴突的完整性和神经元的生存至关重要。