MR-CEST AND REDOX IMAGING OF HUMAN PROSTATE CANCER IN MOUSE XENOGRAFTS
小鼠异种移植物中人类前列腺癌的 MR-CEST 和氧化还原成像
基本信息
- 批准号:8362021
- 负责人:
- 金额:$ 0.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-06-01 至 2012-05-31
- 项目状态:已结题
- 来源:
- 关键词:Adverse effectsBiological MarkersBiopsy SpecimenCancer PatientCell LineChemicalsClassificationClinicalFlavoproteinsFluorescenceFundingGrantHumanImageIn VitroIndolentMCF7 cellMagnetic ResonanceMagnetic Resonance ImagingMalignant neoplasm of prostateMeasuresMelanoma CellMethodsMitochondriaMusNADHNational Center for Research ResourcesNeoplasm MetastasisNicotinamide adenine dinucleotideOxidation-ReductionPatientsPhysiciansPrincipal InvestigatorProtonsRecording of previous eventsResearchResearch InfrastructureResourcesScanningSignal TransductionSourceSpecificityStagingTherapeuticTissuesTumor MarkersUnited States National Institutes of HealthWaterXenograft procedurebasecold temperaturecostfluorescence imagingimaging modalityin vivoindexingmacromoleculemalignant breast neoplasmmelanomamouse modeloptical imagingtumor
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Most cancer patients die of metastasis. Current classification of tumors on the basis of stage and grade cannot predict accurately whether and how soon a tumor will metastasize. Within the same stage and grade, some tumors may metastasize earlier than other tumors. A biomarker of tumor metastatic potential can help physician to select proper aggressiveness of the therapeutic approaches to treat the tumor while minimizing the side effects on patients. In this project we will develop MR and optical imaging methods to predict the aggressiveness of human prostate cancer in mouse xenografts.
Previously we have obtained a panel of five melanoma cell lines with known clinical history, their metastatic potential measured in mouse models and invasive potentials measured in vitro by the Boyden chamber method. In particular, low temperature NADH/Fp (reduced nicotinamide adenine dinucleotide/oxidized flavoproteins including FAD) fluorescence imaging or "redox scanning" (translatable to biopsy specimens) can measure the in vivo mitochondrial redox states of tissues on the basis of the fluorescence signals of NADH, Fp, and Fp redox ratios (Fp/(NADH+Fp)). Redox scanning indicated that the Fp redox ratio in the tumor core correlated significantly with the aggressiveness indices of five melanoma xenografts spanning the full range of potential to metastasis. In addition redox imaging biomarkers have been shown to differentiate between an indolent MCF-7 breast cancer mouse xenografts from an MDA-MB-231 aggressive one. T1rho-MRI is sensitive to proton exchange between water and macromolecules. Previously we have succeeded in using T1rho to differentiate three melanoma xenografts with different aggressiveness. CEST-MRI (Chemical Exchange Saturation Transfer-MRI) is a similar method also sensitive to proton exchange but with more chemical shift specificity. In this project we will employ redox scanning in combination with CEST-MRI to characterize these xenografts of prostate cancer and to identify imaging markers for tumor aggressiveness.
这个子项目是利用这些资源的众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
LIN LI其他文献
LIN LI的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('LIN LI', 18)}}的其他基金
PROBING MELANOMA AGGRESSIVENESS, REDOX STATE AND AUTOPHAGY
探究黑色素瘤的侵袭性、氧化还原状态和自噬
- 批准号:
8362022 - 财政年份:2011
- 资助金额:
$ 0.77万 - 项目类别:
REDOX IMAGING INDIVIDUAL EMBRYONIC STEM CELL COLONIES
单个胚胎干细胞集落的氧化还原成像
- 批准号:
8361993 - 财政年份:2011
- 资助金额:
$ 0.77万 - 项目类别:
MITOCHONDRIAL REDOX STATE AS CLINICAL IMAGING BIOMARKER FOR BREAST CANCER
线粒体氧化还原状态作为乳腺癌的临床成像生物标志物
- 批准号:
8361994 - 财政年份:2011
- 资助金额:
$ 0.77万 - 项目类别:
MITOCHONDRIAL REDOX IMAGING AND CEST-MRI OF BREAST CANCER
乳腺癌的线粒体氧化还原成像和 CEST-MRI
- 批准号:
8362024 - 财政年份:2011
- 资助金额:
$ 0.77万 - 项目类别:
MITOCHONDRIAL REDOX IMAGING OF BIOLOGICAL TISSUES
生物组织的线粒体氧化还原成像
- 批准号:
8361949 - 财政年份:2011
- 资助金额:
$ 0.77万 - 项目类别:
MR AND REDOX IMAGING OF HUMAN MELANOMA MOUSE XENOGRAFTS
人类黑色素瘤小鼠异种移植物的 MR 和氧化还原成像
- 批准号:
8169089 - 财政年份:2010
- 资助金额:
$ 0.77万 - 项目类别:
MITOCHONDRIAL REDOX IMAGING OF BIOLOGICAL TISSUES
生物组织的线粒体氧化还原成像
- 批准号:
8169031 - 财政年份:2010
- 资助金额:
$ 0.77万 - 项目类别:
相似海外基金
MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers
吸烟者和电子烟使用者急性电子烟暴露的 MRI 和生物标志物
- 批准号:
10490338 - 财政年份:2021
- 资助金额:
$ 0.77万 - 项目类别:
MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers
吸烟者和电子烟使用者急性电子烟暴露的 MRI 和生物标志物
- 批准号:
10353104 - 财政年份:2021
- 资助金额:
$ 0.77万 - 项目类别:
Investigating pollution dynamics of swimming pool waters by means of chemical and biological markers
利用化学和生物标记物研究游泳池水体的污染动态
- 批准号:
21K04320 - 财政年份:2021
- 资助金额:
$ 0.77万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers
吸烟者和电子烟使用者急性电子烟暴露的 MRI 和生物标志物
- 批准号:
10688286 - 财政年份:2021
- 资助金额:
$ 0.77万 - 项目类别:
Novel biological markers for immunotherapy and comprehensive genetic analysis in thymic carcinoma
用于胸腺癌免疫治疗和综合遗传分析的新型生物标志物
- 批准号:
20K17755 - 财政年份:2020
- 资助金额:
$ 0.77万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Examination of Biological Markers Associated with Neurobehavioral and Neuropsychological Outcomes in Military Veterans with a History of Traumatic Brain Injury
与有脑外伤史的退伍军人的神经行为和神经心理结果相关的生物标志物的检查
- 批准号:
10578649 - 财政年份:2019
- 资助金额:
$ 0.77万 - 项目类别:
Examination of Biological Markers Associated with Neurobehavioral and Neuropsychological Outcomes in Military Veterans with a History of Traumatic Brain Injury
与有脑外伤史的退伍军人的神经行为和神经心理结果相关的生物标志物的检查
- 批准号:
10295141 - 财政年份:2019
- 资助金额:
$ 0.77万 - 项目类别:
Examination of Biological Markers Associated with Neurobehavioral and Neuropsychological Outcomes in Military Veterans with a History of Traumatic Brain Injury
与有脑外伤史的退伍军人的神经行为和神经心理结果相关的生物标志物的检查
- 批准号:
10041708 - 财政年份:2019
- 资助金额:
$ 0.77万 - 项目类别:
Examination of Biological Markers Associated with Neurobehavioral and Neuropsychological Outcomes in Military Veterans with a History of Traumatic Brain Injury
与有脑外伤史的退伍军人的神经行为和神经心理结果相关的生物标志物的检查
- 批准号:
9776149 - 财政年份:2019
- 资助金额:
$ 0.77万 - 项目类别:
Combining biological and non-biological markers to develop a model predictive of treatment response for individuals with depression
结合生物和非生物标志物来开发预测抑郁症患者治疗反应的模型
- 批准号:
2063934 - 财政年份:2018
- 资助金额:
$ 0.77万 - 项目类别:
Studentship