MITOCHONDRIAL REDOX IMAGING OF COLON CANCER
结肠癌的线粒体氧化还原成像
基本信息
- 批准号:8169087
- 负责人:
- 金额:$ 3.47万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-06-01 至 2011-05-31
- 项目状态:已结题
- 来源:
- 关键词:African AmericanAmerican Indian and Alaska NativeApoptosisAsiansColon CarcinomaComputer Retrieval of Information on Scientific Projects DatabaseDeath RateFlavoproteinsFundingGrantHispanic AmericansHumanImageInstitutionMalignant NeoplasmsMetabolismMitochondriaMusNicotinamide adenine dinucleotideOxidation-ReductionPacific Island AmericansResearchResearch PersonnelResourcesRoleScanningSignal TransductionSourceTP53 geneTechniquesTissuesUnited States National Institutes of HealthWomanXenograft procedurebasecancer therapychemotherapyclinical Diagnosiscold temperaturefluorescence imagingin vivomelanomamen
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Low temperature NADH/Fp (reduced nicotinamide adenine dinucleotide/oxidized flavoproteins)
fluorescence imaging or "redox scanning" has been developed to image the in vivo mitochondrial
redox states of tissues on the basis of the redox ratios (Fp/NADH or Fp/(NADH+Fp)) and may be
useful for clinical diagnosis and treatment of cancer given the central role of mitochondria in
cellular metabolism, apoptosis and signaling transductions. Previously we have applied this
technique to a panel of human melanoma mouse xenografts with different metastatic potential
and identify Fp redox ratio correlates highly significantly with the aggressiveness of these
melanomas. Colon cancer is the third most common cancer in US men and the second most
common cancer in US women of Hispanic, American Indian/Alaska Native, or Asian/Pacific
Islander ancestry, and the third most common cancer in white and African American women.
Its death rate ranked third for both men and women in US. In this subproject we aim to
achieve 1) redox imaging of colon cancer mouse xenografts with different status of p53;
2) redox imaging of colon cancer mouse xenografts receiving a chemotherapy; 3) study of the
connection and interaction between p53 and mitochondrial redox state; 4) comparison of
redox images between colon cancer with different aggressiveness.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
低温NADH/Fp(还原型烟酰胺腺嘌呤二核苷酸/氧化型黄素蛋白)
已经开发了荧光成像或“氧化还原扫描”来对体内线粒体
基于氧化还原比(Fp/NADH或Fp/(NADH+Fp)),可以确定组织的氧化还原状态,并且可以
由于线粒体在癌症中的中心作用,
细胞代谢、凋亡和信号转导。此前,我们已将此
一组具有不同转移潜能人黑素瘤小鼠异种移植物的技术
并确定Fp氧化还原率与这些细胞的侵袭性高度显著相关,
黑素瘤。结肠癌是美国男性第三大常见癌症,
西班牙裔、美洲印第安人/阿拉斯加原住民或亚洲/太平洋裔美国女性的常见癌症
岛民血统,以及白色和非洲裔美国妇女的第三大常见癌症。
它的死亡率在美国男性和女性中排名第三。在这个子项目中,我们的目标是
实现1)p53不同状态结肠癌小鼠移植瘤的氧化还原成像;
2)接受化学疗法的结肠癌小鼠异种移植物的氧化还原成像; 3)对接受化学疗法的结肠癌小鼠异种移植物的氧化还原成像的研究。
p53与线粒体氧化还原状态之间的联系和相互作用;
不同侵袭性结肠癌之间的氧化还原图像。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('LIN LI', 18)}}的其他基金
MR-CEST AND REDOX IMAGING OF HUMAN PROSTATE CANCER IN MOUSE XENOGRAFTS
小鼠异种移植物中人类前列腺癌的 MR-CEST 和氧化还原成像
- 批准号:
8362021 - 财政年份:2011
- 资助金额:
$ 3.47万 - 项目类别:
PROBING MELANOMA AGGRESSIVENESS, REDOX STATE AND AUTOPHAGY
探究黑色素瘤的侵袭性、氧化还原状态和自噬
- 批准号:
8362022 - 财政年份:2011
- 资助金额:
$ 3.47万 - 项目类别:
REDOX IMAGING INDIVIDUAL EMBRYONIC STEM CELL COLONIES
单个胚胎干细胞集落的氧化还原成像
- 批准号:
8361993 - 财政年份:2011
- 资助金额:
$ 3.47万 - 项目类别:
MITOCHONDRIAL REDOX STATE AS CLINICAL IMAGING BIOMARKER FOR BREAST CANCER
线粒体氧化还原状态作为乳腺癌的临床成像生物标志物
- 批准号:
8361994 - 财政年份:2011
- 资助金额:
$ 3.47万 - 项目类别:
MITOCHONDRIAL REDOX IMAGING AND CEST-MRI OF BREAST CANCER
乳腺癌的线粒体氧化还原成像和 CEST-MRI
- 批准号:
8362024 - 财政年份:2011
- 资助金额:
$ 3.47万 - 项目类别:
MITOCHONDRIAL REDOX IMAGING OF BIOLOGICAL TISSUES
生物组织的线粒体氧化还原成像
- 批准号:
8361949 - 财政年份:2011
- 资助金额:
$ 3.47万 - 项目类别:
MR AND REDOX IMAGING OF HUMAN MELANOMA MOUSE XENOGRAFTS
人类黑色素瘤小鼠异种移植物的 MR 和氧化还原成像
- 批准号:
8169089 - 财政年份:2010
- 资助金额:
$ 3.47万 - 项目类别:
MITOCHONDRIAL REDOX IMAGING OF BIOLOGICAL TISSUES
生物组织的线粒体氧化还原成像
- 批准号:
8169031 - 财政年份:2010
- 资助金额:
$ 3.47万 - 项目类别:
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