PROBING MELANOMA AGGRESSIVENESS, REDOX STATE AND AUTOPHAGY

探究黑色素瘤的侵袭性、氧化还原状态和自噬

基本信息

  • 批准号:
    8362022
  • 负责人:
  • 金额:
    $ 0.77万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-06-01 至 2012-05-31
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. While patients with metastatic cancer usually have a variable response to treatment and time to death, understanding the mechanisms that contribute to the heterogeneity of aggressiveness remains a major issue in effective cancer diagnosis and therapy. Previous studies utilizing a set of magnetic resonance (MR) and optical imaging techniques and histology assays have characterized a panel of human melanoma mouse xenografts spanning a full range of progression to metastasis. Despite the metabolic challenges such as low blood perfusion and presumably nutrition starvation, the aggressive tumor cores contained few apoptotic cells as shown by TUNEL assay. Autophagy promotes the survival of cancer cells under starvation or under conditions of cellular stress. We hypothesize that higher autophagy is associated with more aggressive cancer and autophagy may provide new insight into the mechanisms of cancer metastasis and support the development of novel therapeutic approaches by targeting autophagy.
这个子项目是利用这些资源的众多研究子项目之一

项目成果

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LIN LI其他文献

LIN LI的其他文献

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{{ truncateString('LIN LI', 18)}}的其他基金

MR-CEST AND REDOX IMAGING OF HUMAN PROSTATE CANCER IN MOUSE XENOGRAFTS
小鼠异种移植物中人类前列腺癌的 MR-CEST 和氧化还原成像
  • 批准号:
    8362021
  • 财政年份:
    2011
  • 资助金额:
    $ 0.77万
  • 项目类别:
REDOX IMAGING OF HUMAN LYMPHOMA
人类淋巴瘤的氧化还原成像
  • 批准号:
    8362023
  • 财政年份:
    2011
  • 资助金额:
    $ 0.77万
  • 项目类别:
REDOX IMAGING INDIVIDUAL EMBRYONIC STEM CELL COLONIES
单个胚胎干细胞集落的氧化还原成像
  • 批准号:
    8361993
  • 财政年份:
    2011
  • 资助金额:
    $ 0.77万
  • 项目类别:
MITOCHONDRIAL REDOX STATE AS CLINICAL IMAGING BIOMARKER FOR BREAST CANCER
线粒体氧化还原状态作为乳腺癌的临床成像生物标志物
  • 批准号:
    8361994
  • 财政年份:
    2011
  • 资助金额:
    $ 0.77万
  • 项目类别:
MITOCHONDRIAL REDOX IMAGING AND CEST-MRI OF BREAST CANCER
乳腺癌的线粒体氧化还原成像和 CEST-MRI
  • 批准号:
    8362024
  • 财政年份:
    2011
  • 资助金额:
    $ 0.77万
  • 项目类别:
MITOCHONDRIAL REDOX IMAGING OF BIOLOGICAL TISSUES
生物组织的线粒体氧化还原成像
  • 批准号:
    8361949
  • 财政年份:
    2011
  • 资助金额:
    $ 0.77万
  • 项目类别:
MR AND REDOX IMAGING OF HUMAN MELANOMA MOUSE XENOGRAFTS
人类黑色素瘤小鼠异种移植物的 MR 和氧化还原成像
  • 批准号:
    8169089
  • 财政年份:
    2010
  • 资助金额:
    $ 0.77万
  • 项目类别:
REDOX IMAGING OF STEM CELLS
干细胞的氧化还原成像
  • 批准号:
    8169088
  • 财政年份:
    2010
  • 资助金额:
    $ 0.77万
  • 项目类别:
MITOCHONDRIAL REDOX IMAGING OF BIOLOGICAL TISSUES
生物组织的线粒体氧化还原成像
  • 批准号:
    8169031
  • 财政年份:
    2010
  • 资助金额:
    $ 0.77万
  • 项目类别:
MITOCHONDRIAL REDOX IMAGING OF COLON CANCER
结肠癌的线粒体氧化还原成像
  • 批准号:
    8169087
  • 财政年份:
    2010
  • 资助金额:
    $ 0.77万
  • 项目类别:
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