REDOX IMAGING OF HUMAN LYMPHOMA

人类淋巴瘤的氧化还原成像

• 批准号: 8362023
• 负责人: LIN LI
• 金额: $ 0.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362023
• 关键词: Apoptosis; Cell Culture Techniques; Cell physiology; Flavoproteins; Fluorescence; Funding; Grant; Human; Image; Lymphoma; Magnetic Resonance; Measures; Metabolism; Mitochondria; Mus; NADH; National Center for Research Resources; Oxidation-Reduction; Principal Investigator; Research; Research Infrastructure; Resources; Role; Scanning; Signal Transduction; Source; Tissues; United States National Institutes of Health; Xenograft procedure; base; cancer therapy; chemotherapy; cost; in vivo; malignant breast neoplasm; melanoma; novel strategies; optical imaging; response; tumor progression

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Redox scanning can measure the in vivo mitochondrial redox states of tissues on the basis of the fluorescence signals of NADH and Fp (oxidized flavoproteins), and Fp redox ratios (Fp/(NADH+Fp)) was shown by previous studies to predict the aggressiveness of human melanoma and breast cancer in mouse xenografts. Redox ratio is also sensitive to cellular processes including apoptosis, differentiation and metabolism. In this project we employ redox scanning to study human lymphoma cell culture and mouse xenografts with and without chemotherapy. We hope to understand more about the role of mitochondrial redox state in tumor progression and response to treatment. We may also accumulate evidence for targeting mitochondrial redox state as a novel approach of cancer therapy.

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